ID   NCA2_DICDI              Reviewed;         923 AA.
AC   Q55GJ3;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Nuclear control of ATPase protein 2;
GN   Name=nca2; ORFNames=DDB_G0267648;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in the mitochondrial expression of subunits 6 and 8
CC       of the F0-F1 ATP synthase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NCA2 family. {ECO:0000305}.
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DR   EMBL; AAFI02000003; EAL73277.1; -; Genomic_DNA.
DR   RefSeq; XP_647191.1; XM_642099.1.
DR   AlphaFoldDB; Q55GJ3; -.
DR   STRING; 44689.DDB0189431; -.
DR   PaxDb; Q55GJ3; -.
DR   PRIDE; Q55GJ3; -.
DR   EnsemblProtists; EAL73277; EAL73277; DDB_G0267648.
DR   GeneID; 8615995; -.
DR   KEGG; ddi:DDB_G0267648; -.
DR   dictyBase; DDB_G0267648; -.
DR   eggNOG; ENOG502QQIS; Eukaryota.
DR   HOGENOM; CLU_316291_0_0_1; -.
DR   InParanoid; Q55GJ3; -.
DR   OMA; PLFWLKY; -.
DR   PRO; PR:Q55GJ3; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   InterPro; IPR013946; NCA2.
DR   PANTHER; PTHR28234; PTHR28234; 1.
DR   Pfam; PF08637; NCA2; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..923
FT                   /note="Nuclear control of ATPase protein 2"
FT                   /id="PRO_0000374013"
FT   TRANSMEM        745..765
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        808..828
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          69..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          182..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          335..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        335..362
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        363..385
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   923 AA;  107945 MW;  B0F0D2D08D1CA981 CRC64;
     MGSITHNKGN QIKKKLDSFI GISNWESLSI EHDNINHQLD ITLLAIIKDI TNKPDYSSCT
     TTTTTTTITT NNNNNNNNNN VNKNEDNSNT TNNNLIKSIN KEVENSSVNN NGFISMNQQK
     QNYHYNIPTS LKDIKSIIIK SQKLKGQLQS LKQVFKQNII INNQEVIEQQ VDAIKQQQQQ
     QQEQQQEQEQ EQQQQQDGES ISLSSSTSSG ITISSLSNIE YNPSIAFKLG KEFVIGNLFI
     DQIILFLEFL YGIALEIETN LQYWESIEPT IYYLQKSPLF WLKYYHQQLN RRIQFSNKFS
     ELHNLKQPKP ILYISNLLNK VNSFILNKQP SSQQVEQQQQ QQQERDEQQQ QQQQQQQQQQ
     QHNNSHHHHH HRNENEKKKK SKRIKHPKIE LLDKIQKLKS YQVVISVIIG RLTFLLDSLK
     INTNNNNNNN NTADNNNNNL NDNESIKRFS ELMSKSSIII FDSLLLFNEL FKKNKESNDN
     DKKVDDDDEL IKLSKDLINE IINIRNEDGD QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQSL
     QLLNFKILLN NQNLINKLME VMVKRLSGNL SIPNVFIRNW VKLSVGSVIV FFGIKYSYDN
     FDSFKQSAFD IRDAFIRFYH EHLEEPLLNI WNVIRYDKKS LQLADPASLQ SSIDSLGRMV
     IDYNIDRNHL DINSTETRQH LFQLASRGDI SSIMKSYESN IRSPLQNILF GDMIRLILIQ
     IQKEKVDVDK AMVAIDKLLQ ANELNFQLLA AIPSAIFLAL LIWQIKKLFT NQKKTLPYSQ
     LVIFQTLRKI NRTLILNNTQ DQQNNNLPNF ISPLLLTQIN ILNYSTIINN QDNNNNINNI
     NNNNNNNNNQ LIKTQFKPFE KYGTILISTN KLRSHQRFVR ENTESQWFNQ DVHDLESEAL
     SNQDKIQTIN RMFQTYSFLK NIK