ID   NCA2_SCHPO              Reviewed;         573 AA.
AC   O74963;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Nuclear control of ATPase protein 2;
GN   Name=nca2; ORFNames=SPBC4B4.02c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Involved in the mitochondrial expression of subunits 6 and 8
CC       of the F0-F1 ATP synthase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NCA2 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA19282.1; -; Genomic_DNA.
DR   PIR; T40474; T40474.
DR   RefSeq; NP_596419.1; NM_001022338.2.
DR   AlphaFoldDB; O74963; -.
DR   STRING; 4896.SPBC4B4.02c.1; -.
DR   iPTMnet; O74963; -.
DR   MaxQB; O74963; -.
DR   PaxDb; O74963; -.
DR   PRIDE; O74963; -.
DR   EnsemblFungi; SPBC4B4.02c.1; SPBC4B4.02c.1:pep; SPBC4B4.02c.
DR   GeneID; 2540670; -.
DR   KEGG; spo:SPBC4B4.02c; -.
DR   PomBase; SPBC4B4.02c; nca2.
DR   VEuPathDB; FungiDB:SPBC4B4.02c; -.
DR   eggNOG; ENOG502QTT6; Eukaryota.
DR   HOGENOM; CLU_008227_1_0_1; -.
DR   InParanoid; O74963; -.
DR   OMA; WYWDDIL; -.
DR   PhylomeDB; O74963; -.
DR   PRO; PR:O74963; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR   GO; GO:0016071; P:mRNA metabolic process; ISO:PomBase.
DR   InterPro; IPR013946; NCA2.
DR   PANTHER; PTHR28234; PTHR28234; 1.
DR   Pfam; PF08637; NCA2; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..573
FT                   /note="Nuclear control of ATPase protein 2"
FT                   /id="PRO_0000374014"
FT   TRANSMEM        447..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        513..533
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   573 AA;  65809 MW;  079E2E7540168E97 CRC64;
     MELYQKHLKD VYANFNKLAA VHGETTSNSV TFHVFQQLDS TNLTNYQLEN VITQVKELDK
     GPKDYLYWVI LGRCSAHLHV KMLDQLLEEA MIMSDNLHYW ESIDKNWYSR VLFLIQSFPT
     RLYHICRNSI KSILQFQNFS NIFAKKNLFP KVSKSDVLLF PRDAFISQAS LLSLIRHEYR
     GNAKRLRQLR DEHACKIGCL TRAIMSEGVS DAASSSGDKN GISAKADLKQ VVSQWIQRLS
     QLQGQKIDNS ESLPDILSIT LDNLSHPTDE YFEAKAYFRP SAIERNWPKI FVTLLSAWLS
     TQIITKNRTS IRLWIDYLYS TAVDFYTNWI QKPILGIFDT IRSNRADSQI TLLQTKSLES
     DMESLQRMVI DFVSDTSPAG INLDLVKQEV QQGDLTYVLQ AYEHDLKTPI RTAVSGNLVR
     TLLIQLQKTK VDVEVALSGI DRLLKSQELV FATVGITPSL IFCYVIIRYV KANIFNNDTL
     SRAERRQRFR QSLRAAERIL VRSQKMNSLD DMSYGLLVFQ VNLMAIMSMD MGLSKDVAED
     LLQDLEDIQS SSYGVQAQLR AVDRIYRLFK NSI