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NCALD_RAT
ID   NCALD_RAT               Reviewed;         193 AA.
AC   Q5PQN0;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Neurocalcin-delta;
GN   Name=Ncald;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PROTEIN SEQUENCE OF 51-94; 119-130; 138-148; 164-171 AND 175-181, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RA   Lubec G., Kang S.U., Lubec S.;
RL   Submitted (SEP-2007) to UniProtKB.
RN   [3]
RP   INTERACTION WITH GUCY2D.
RX   PubMed=18178149; DOI=10.1016/j.bbrc.2007.12.153;
RA   Duda T., Sharma R.K.;
RT   "ONE-GC membrane guanylate cyclase, a trimodal odorant signal transducer.";
RL   Biochem. Biophys. Res. Commun. 367:440-445(2008).
CC   -!- FUNCTION: May be involved in the calcium-dependent regulation of
CC       rhodopsin phosphorylation. Binds three calcium ions (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with GUCY2D. {ECO:0000269|PubMed:18178149}.
CC   -!- SIMILARITY: Belongs to the recoverin family. {ECO:0000305}.
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DR   EMBL; BC087105; AAH87105.1; -; mRNA.
DR   RefSeq; NP_001019542.1; NM_001024371.1.
DR   RefSeq; XP_008763678.1; XM_008765456.2.
DR   RefSeq; XP_017450554.1; XM_017595065.1.
DR   RefSeq; XP_017450555.1; XM_017595066.1.
DR   AlphaFoldDB; Q5PQN0; -.
DR   SMR; Q5PQN0; -.
DR   BioGRID; 275016; 4.
DR   STRING; 10116.ENSRNOP00000062447; -.
DR   jPOST; Q5PQN0; -.
DR   PaxDb; Q5PQN0; -.
DR   PRIDE; Q5PQN0; -.
DR   Ensembl; ENSRNOT00000080024; ENSRNOP00000073597; ENSRNOG00000042978.
DR   GeneID; 553106; -.
DR   KEGG; rno:553106; -.
DR   UCSC; RGD:1560287; rat.
DR   CTD; 83988; -.
DR   RGD; 1560287; Ncald.
DR   eggNOG; KOG0044; Eukaryota.
DR   GeneTree; ENSGT00940000158862; -.
DR   HOGENOM; CLU_072366_1_0_1; -.
DR   InParanoid; Q5PQN0; -.
DR   OMA; MGCVCMK; -.
DR   OrthoDB; 1369072at2759; -.
DR   PhylomeDB; Q5PQN0; -.
DR   Reactome; R-RNO-451308; Activation of Ca-permeable Kainate Receptor.
DR   PRO; PR:Q5PQN0; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000042978; Expressed in Ammon's horn and 20 other tissues.
DR   Genevisible; Q5PQN0; RN.
DR   GO; GO:0005829; C:cytosol; IDA:RGD.
DR   GO; GO:0003779; F:actin binding; IDA:RGD.
DR   GO; GO:0043014; F:alpha-tubulin binding; IDA:RGD.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0030276; F:clathrin binding; ISO:RGD.
DR   GO; GO:0015631; F:tubulin binding; ISO:RGD.
DR   GO; GO:0019722; P:calcium-mediated signaling; ISO:RGD.
DR   GO; GO:0003073; P:regulation of systemic arterial blood pressure; ISO:RGD.
DR   CDD; cd00051; EFh; 2.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR028846; Recoverin.
DR   PANTHER; PTHR23055; PTHR23055; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   SMART; SM00054; EFh; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 3.
DR   PROSITE; PS50222; EF_HAND_2; 4.
PE   1: Evidence at protein level;
KW   Calcium; Direct protein sequencing; Lipoprotein; Metal-binding; Myristate;
KW   Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..193
FT                   /note="Neurocalcin-delta"
FT                   /id="PRO_0000249733"
FT   DOMAIN          40..58
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          60..95
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          96..131
FT                   /note="EF-hand 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          144..179
FT                   /note="EF-hand 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         73
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         75
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         77
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         79
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         84
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         109
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         111
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         113
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         115
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         120
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         157
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         159
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         161
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         163
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         168
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   193 AA;  22245 MW;  20DD8B6FF47C4CBF CRC64;
     MGKQNSKLRP EVMQDLLEST DFTEHEIQEW YKGFLRDCPS GHLSMEEFKK IYGNFFPYGD
     ASKFAEHVFR TFDANGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISKAE
     MLEIVQAIYK MVSSVMKMPE DESTPEKRTE KIFRQMDTNR DGKLSLEEFI RGAKSDPSIV
     RLLQCDPSSA GQF
 
 
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