ID   NCAP_AMPV1              Reviewed;         394 AA.
AC   Q2Y2M6;
DT   15-DEC-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   02-JUN-2021, entry version 48.
DE   RecName: Full=Nucleoprotein;
DE            Short=Protein N;
DE   AltName: Full=Nucleocapsid protein;
GN   Name=N;
OS   Avian metapneumovirus (isolate Canada goose/Minnesota/15a/2001) (AMPV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Pneumoviridae; Metapneumovirus.
OX   NCBI_TaxID=652954;
OH   NCBI_TaxID=8847; Anser sp. (goose).
OH   NCBI_TaxID=9103; Meleagris gallopavo (Wild turkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15666873; DOI=10.1637/7208-051804r;
RA   Bennett R.S., Nezworski J., Velayudhan B.T., Nagaraja K.V., Zeman D.H.,
RA   Dyer N., Graham T., Lauer D.C., Njenga M.K., Halvorson D.A.;
RT   "Evidence of avian pneumovirus spread beyond Minnesota among wild and
RT   domestic birds in central North America.";
RL   Avian Dis. 48:902-908(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16282483; DOI=10.1128/jvi.79.23.14834-14842.2005;
RA   Bennett R.S., LaRue R., Shaw D., Yu Q., Nagaraja K.V., Halvorson D.A.,
RA   Njenga M.K.;
RT   "A wild goose metapneumovirus containing a large attachment glycoprotein is
RT   avirulent but immunoprotective in domestic turkeys.";
RL   J. Virol. 79:14834-14842(2005).
RN   [3]
RP   ALTERNATIVE INITIATION.
RC   STRAIN=Isolate Meleagris gallopavo/United States/Colorado/1996;
RX   PubMed=15826312; DOI=10.1186/1743-422x-2-31;
RA   Alvarez R., Seal B.S.;
RT   "Identification of a truncated nucleoprotein in avian metapneumovirus-
RT   infected cells encoded by a second AUG, in-frame to the full-length gene.";
RL   Virol. J. 2:31-31(2005).
CC   -!- FUNCTION: Encapsidates the viral RNA genome by forming a left-handed
CC       helical nucleocapsid that protects the RNA from nucleases. RNA
CC       replication depends on the availability of soluble nucleoprotein. The
CC       encapsidated genomic RNA is termed the NC and serves as template for
CC       transcription and replication. {ECO:0000250|UniProtKB:P03418}.
CC   -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC       genomic RNA. Interacts with the phosphoprotein P. When in a monomeric
CC       RNA-free form, interacts with the phosphoprotein (via N-terminus).
CC       Interacts with protein M2-1; this interaction allows the association of
CC       nucleocapsid with the matrix protein. {ECO:0000250|UniProtKB:P03418}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:P03418}. Host
CC       cytoplasm {ECO:0000250|UniProtKB:P03418}. Note=Localizes in cytoplasmic
CC       inclusion bodies. {ECO:0000250|UniProtKB:P03418}.
CC   -!- SIMILARITY: Belongs to the paramyxoviruses nucleocapsid family.
CC       {ECO:0000305}.
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DR   EMBL; DQ009484; AAY81654.1; -; Viral_cRNA.
DR   RefSeq; YP_443837.1; NC_007652.1.
DR   SMR; Q2Y2M6; -.
DR   Proteomes; UP000002471; Genome.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004930; Pneumo_ncap.
DR   Pfam; PF03246; Pneumo_ncap; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Helical capsid protein; Host cytoplasm; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Viral nucleoprotein; Virion.
FT   CHAIN           1..394
FT                   /note="Nucleoprotein"
FT                   /id="PRO_0000390371"
FT   REGION          131..153
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   394 AA;  43229 MW;  37E47DD85630861B CRC64;
     MSLQGIQLSD LSYKHAILKE SQYTIKRDVG TTPAVTPSSL QREVSLLCGE ILYAKHTDYS
     HAAEVGMQYV STTLGAERTQ QILKNSGSEV QAVLTKTYSL GKGKNSKGEE LQMLDIHGVE
     KSWVEEVDKE ARKTMASATK DNSGPIPQNQ RPSSPDAPII LLCIGALIFT KPASTIEVGL
     ETAVRRANRV LNDALKRFPR IDIPKIARSF YDLFEQKVYY RSLFIEYGKA LGSSSTGSKA
     ESLFVNIFMQ AYGAGQTMLR WGAIARSSNN IMLGHVSVQA ELKQVTEVYD LVREMGPESG
     LLHLRQSPKA GLLSLANCPN FASVVLGNAS GLGILGMYRG RVPNTELFAA AESYARSLKE
     SNKINFSSLG LTEEEKEAAE NFLNINEEGQ NDYE