ID   NCAP_ARV                Reviewed;         429 AA.
AC   Q65111;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   29-SEP-2021, entry version 74.
DE   RecName: Full=Nucleoprotein;
DE            Short=NP;
DE   AltName: Full=Nucleocapsid protein;
DE            Short=Protein N;
GN   Name=N;
OS   Adelaide River virus (ARV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC   Ephemerovirus.
OX   NCBI_TaxID=31612;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=89462; Bubalus bubalis (Domestic water buffalo).
OH   NCBI_TaxID=58271; Culicoides.
OH   NCBI_TaxID=9970; Syncerus caffer (African buffalo).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=DPP61;
RX   PubMed=9049348; DOI=10.1099/0022-1317-76-4-995;
RA   Wang Y., Cowley J.A., Walker P.J.;
RT   "Adelaide River virus nucleoprotein gene: analysis of phylogenetic
RT   relationships of ephemeroviruses and other rhabdoviruses.";
RL   J. Gen. Virol. 76:995-999(1995).
CC   -!- FUNCTION: Encapsidates the genome, protecting it from nucleases. If
CC       expressed without protein P it binds non-specifically RNA and therefore
CC       can bind it's own mRNA. Interaction with protein P abolishes any non-
CC       specific RNA binding, and prevents phosphorylation. The soluble N-P
CC       complex encapsidates specifically the genomic RNA, with protein N
CC       protecting the genome like a pearl necklace. The encapsidated genomic
CC       RNA is termed the nucleocapsid (NC) and serves as template for viral
CC       transcription and replication. Protein N binds protein P in the NC
CC       through a different interaction, and can be phosphorylated. Subsequent
CC       viral replication is dependent on intracellular concentration of newly
CC       synthesized protein N. During replication, encapsidation by protein N
CC       is coupled to RNA synthesis and all replicative products are resistant
CC       to nucleases (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC       genomic RNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ephemerovirus nucleocapsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; U10363; AAC54627.1; -; Genomic_RNA.
DR   RefSeq; YP_009177239.1; NC_028246.1.
DR   SMR; Q65111; -.
DR   PRIDE; Q65111; -.
DR   GeneID; 26123217; -.
DR   KEGG; vg:26123217; -.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3570.10; -; 1.
DR   Gene3D; 1.10.3610.10; -; 1.
DR   InterPro; IPR000448; Rhabdo_ncapsid.
DR   InterPro; IPR023331; Rhabdovirus_ncapsid_C.
DR   InterPro; IPR023330; Rhabdovirus_ncapsid_N.
DR   InterPro; IPR035961; Rhabdovirus_nucleoprotein-like.
DR   Pfam; PF00945; Rhabdo_ncap; 1.
DR   SUPFAM; SSF140809; SSF140809; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Helical capsid protein; Host cytoplasm; Phosphoprotein;
KW   Ribonucleoprotein; RNA-binding; Viral nucleoprotein; Virion.
FT   CHAIN           1..429
FT                   /note="Nucleoprotein"
FT                   /id="PRO_0000297607"
FT   REGION          355..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        362..378
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   429 AA;  49533 MW;  BD15D01651306117 CRC64;
     MFCTINQKAV QPAKPSDTTT PQYPADFFNK NNHQKPTVRV TQRGYKIQEL REIISNGIVQ
     DDLNSHHVVR YMELIMEDIT DTLDEDWNSF GVKIGRKGDK ITPLSLVNVM IEEDELIDGK
     RNNGVNKKDD KWIMLVITSY YRFAFSQNQN HRSNLITKLN LQLRTFLKDP PTIVDNMGLF
     TSLISNINFT KLISALDMFL NRFKNNDWSY LRFGTIASRY KDCSALMSLS HVCDVTGMKM
     EEFMDWIFVY STGEDMIKLM KEGNEIDNPM SYMPYTMSMG LSTKSPYSSI NCPSIYSFIH
     MLGSFLGSER SRNARMVSEN NIVNLKVNAG VVSYVKSHRA SMIKAFISND VKEQWYNNDD
     NDNENGGDDE SDEELDEMPK GDNPVEWFMY LESRHFELPE EIKNFMNREA RKITNPRVGT
     IGKFVSTMN