ID   A18_YLDV                Reviewed;         479 AA.
AC   Q9DHK3;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Transcript termination protein A18;
DE            EC=3.6.4.-;
GN   OrderedLocusNames=110R;
OS   Yaba-like disease virus (YLDV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Yatapoxvirus.
OX   NCBI_TaxID=132475;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=314293; Simiiformes.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11277691; DOI=10.1006/viro.2000.0761;
RA   Lee H.-J., Essani K., Smith G.L.;
RT   "The genome sequence of Yaba-like disease virus, a yatapoxvirus.";
RL   Virology 281:170-192(2001).
CC   -!- FUNCTION: DNA helicase which seems to act as a postreplicative
CC       transcription termination factor. Involved in ATP-dependent release of
CC       nascent RNA. Forms a stable complex with single-stranded DNA, and to a
CC       lesser extent RNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with G2. Might be part of a transcription complex
CC       composed at least of G2, A18, and H5. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Note=Localizes to the
CC       virion core. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the helicase family. Poxviruses subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AJ293568; CAC21348.1; -; Genomic_DNA.
DR   RefSeq; NP_073495.1; NC_002642.1.
DR   GeneID; 918615; -.
DR   KEGG; vg:918615; -.
DR   Proteomes; UP000136581; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA-binding; Helicase; Hydrolase; Late protein;
KW   Nucleotide-binding; Reference proteome; Transcription; Virion.
FT   CHAIN           1..479
FT                   /note="Transcript termination protein A18"
FT                   /id="PRO_0000102189"
FT   DOMAIN          99..255
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   DOMAIN          308..469
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT   MOTIF           205..208
FT                   /note="DESH box"
FT   BINDING         112..119
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   479 AA;  55647 MW;  3057930013EBAA67 CRC64;
     MSVCTEIDYK LYTELKKIAG NSLFLFNENG DFTEVVLNSS FKFLVPIGFF SSIDIPLKKP
     IEYKNNNNNI EHSKNIILPN LYPFQKHVVS EVLLSMEKKN KHKRPTYITL HLACGFGKTI
     TSCYLLSLHK KKAVICLPNK MLINQWKRAI ESINMDHIVS VDGVSNLLKE MVKKTADILI
     IVSRHLLNEE FCKKIYLNYD IFILDESHMY NLMNNSAVTK FLTYYPPKVC YFLTATPRKV
     NRIYCNDIIN VSNSLELKKY IKIVEFFFET YSSDTIKQMV KKLNTNYNKY HMYTEKILAE
     DVPRNELILD TIIYDFNKML INRLIIVTKL RKHMMFFYDR LSEKFGLDVV YLGDAKNKNI
     SDIVKKIKSI DRFIFISTTN YSGTGLDVPT LDSLVICSAV MNSMQIEQIL GRICRSSVSK
     TRTVIVFPNT SIKEIKHMVG FFTQKIITLA IEKLNFKKIE KKGKKKELAL CKAFNLQTH