ID   NCAP_BUNL8              Reviewed;         235 AA.
AC   Q8JPR0;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   29-SEP-2021, entry version 56.
DE   RecName: Full=Nucleoprotein;
DE   AltName: Full=Nucleocapsid protein;
DE            Short=Protein N;
GN   Name=N;
OS   Bunyavirus La Crosse (isolate Human/United States/L78/1978).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Ellioviricetes; Bunyavirales; Peribunyaviridae; Orthobunyavirus;
OC   La Crosse orthobunyavirus.
OX   NCBI_TaxID=796210;
OH   NCBI_TaxID=9850; Cervidae (deer).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=7162; Ochlerotatus triseriatus (Eastern treehole mosquito) (Aedes triseriatus).
OH   NCBI_TaxID=13712; Tamias.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA   Hughes M.T., Kempf B.J., Blair C.D., Beaty B.J.;
RT   "Complete sequence of the Bunyavirus, La Crosse virus, Human/78 strain.";
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=17488515; DOI=10.1186/1743-422x-4-41;
RA   Bennett R.S., Ton D.R., Hanson C.T., Murphy B.R., Whitehead S.S.;
RT   "Genome sequence analysis of La Crosse virus and in vitro and in vivo
RT   phenotypes.";
RL   Virol. J. 4:41-41(2007).
CC   -!- FUNCTION: Encapsidates the genome protecting it from nucleases. The
CC       encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as
CC       template for transcription and replication. Seems to participate in the
CC       nuclear relocalization of host PABP1, thereby inhibiting host cellular
CC       translation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC       genomic RNA. Interacts with host PABP1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Note=Internal protein of virus particle.
CC   -!- SIMILARITY: Belongs to the orthobunyavirus nucleocapsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF528167; AAM94389.1; -; Genomic_RNA.
DR   EMBL; EF485033; ABQ12632.1; -; Viral_cRNA.
DR   RefSeq; NP_671970.1; NC_004110.1.
DR   SMR; Q8JPR0; -.
DR   PRIDE; Q8JPR0; -.
DR   GeneID; 956556; -.
DR   KEGG; vg:956556; -.
DR   Proteomes; UP000008768; Genome.
DR   Proteomes; UP000121242; Genome.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.472.180; -; 1.
DR   Gene3D; 1.20.142.20; -; 1.
DR   InterPro; IPR001784; Bunya_nucleocap.
DR   InterPro; IPR043011; Bunya_nucleocap_C.
DR   InterPro; IPR043012; Bunya_nucleocap_N.
DR   Pfam; PF00952; Bunya_nucleocap; 1.
DR   PIRSF; PIRSF003947; N_OrthobunV; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Eukaryotic host gene expression shutoff by virus;
KW   Eukaryotic host translation shutoff by virus; Helical capsid protein;
KW   Host gene expression shutoff by virus; Host-virus interaction;
KW   Reference proteome; Ribonucleoprotein; RNA-binding; Viral nucleoprotein;
KW   Virion.
FT   CHAIN           1..235
FT                   /note="Nucleoprotein"
FT                   /id="PRO_0000397188"
SQ   SEQUENCE   235 AA;  26556 MW;  152DD6D13709F891 CRC64;
     MSDLVFYDVA STGANGFDPD AGYMDFCVKN AELLNLAAVR IFFLNAAKAK AALSRKPERK
     ANPKFGEWQV EVINNHFPGN RNNPIGNNDL TIHRLSGYLA RWVLDQYNEN DDESQHELIR
     TTIINPIAES NGVGWDSGPE IYLSFFPGTE MFLETFKFYP LTIGIHRVKQ GMMDPQYLKK
     ALRQRYGTLT ADKWMSQKVA AIAKSLKDVE QLKWGKGGLS DTAKTFLQKF GIRLP