ID   NCAP_BUNSH              Reviewed;         235 AA.
AC   P03513;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   29-SEP-2021, entry version 69.
DE   RecName: Full=Nucleoprotein;
DE   AltName: Full=Nucleocapsid protein;
DE            Short=Protein N;
GN   Name=N;
OS   Bunyavirus snowshoe hare.
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Ellioviricetes; Bunyavirales; Peribunyaviridae; Orthobunyavirus;
OC   Snowshoe hare orthobunyavirus.
OX   NCBI_TaxID=11580;
OH   NCBI_TaxID=7158; Aedes.
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
OH   NCBI_TaxID=7174; Culex.
OH   NCBI_TaxID=174825; Culiseta.
OH   NCBI_TaxID=9796; Equus caballus (Horse).
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=48086; Lepus americanus (Snowshoe hare).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=7050911; DOI=10.1093/nar/10.12.3703;
RA   Bishop D.H.L., Gould K.G., Akashi H., Clerx-Van Haaster C.M.;
RT   "The complete sequence and coding content of snowshoe hare bunyavirus small
RT   (S) viral RNA species.";
RL   Nucleic Acids Res. 10:3703-3713(1982).
CC   -!- FUNCTION: Encapsidates the genome protecting it from nucleases. The
CC       encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as
CC       template for transcription and replication. Seems to participate in the
CC       nuclear relocalization of host PABP1, thereby inhibiting host cellular
CC       translation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC       genomic RNA. Interacts with host PABP1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Note=Internal protein of virus particle.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=N;
CC         IsoId=P03513-1; Sequence=Displayed;
CC       Name=NSS;
CC         IsoId=P03514-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the orthobunyavirus nucleocapsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; J02390; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   PIR; A04103; VHVUNH.
DR   SMR; P03513; -.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.472.180; -; 1.
DR   Gene3D; 1.20.142.20; -; 1.
DR   InterPro; IPR001784; Bunya_nucleocap.
DR   InterPro; IPR043011; Bunya_nucleocap_C.
DR   InterPro; IPR043012; Bunya_nucleocap_N.
DR   Pfam; PF00952; Bunya_nucleocap; 1.
DR   PIRSF; PIRSF003947; N_OrthobunV; 1.
PE   3: Inferred from homology;
KW   Alternative initiation; Capsid protein;
KW   Eukaryotic host gene expression shutoff by virus;
KW   Eukaryotic host translation shutoff by virus; Helical capsid protein;
KW   Host gene expression shutoff by virus; Host-virus interaction;
KW   Ribonucleoprotein; RNA-binding; Viral nucleoprotein; Virion.
FT   CHAIN           1..235
FT                   /note="Nucleoprotein"
FT                   /id="PRO_0000221991"
SQ   SEQUENCE   235 AA;  26771 MW;  687ED1D57AC097F8 CRC64;
     MSDLVFYDVA STGANGFDPD AGYMAFCVKY AESVNLAAVR IFFLNAAKAK AALSRKPERK
     ANPKFGEWQV EVVNNHFPGN RNNPINSDDL TIHRLSGYLA RWVLEQYKEN EDESRRELIK
     TTIINPIAES NGVRWDSGAE IYLSFFPGTE MFLETFKFYP LTIGIYRVKQ GMMDPQYLKK
     ALRQRYGSLT ADKWMSQKVT AIAKSLKEVE QLKWGRGGLS DTARSFLQKF GIRLP