NCAP_CDVO
ID NCAP_CDVO Reviewed; 523 AA.
AC P04865; Q91KN6; Q9DXZ4;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2003, sequence version 3.
DT 02-JUN-2021, entry version 80.
DE RecName: Full=Nucleoprotein;
DE Short=Protein N;
DE AltName: Full=Nucleocapsid protein;
GN Name=N;
OS Canine distemper virus (strain Onderstepoort) (CDV).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC Morbillivirus.
OX NCBI_TaxID=11233;
OH NCBI_TaxID=9646; Ailuropoda melanoleuca (Giant panda).
OH NCBI_TaxID=9649; Ailurus fulgens (Lesser panda) (Red panda).
OH NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
OH NCBI_TaxID=9665; Mustela.
OH NCBI_TaxID=9689; Panthera leo (Lion).
OH NCBI_TaxID=9654; Procyon lotor (Raccoon).
OH NCBI_TaxID=9704; Zalophus californianus (California sealion).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=8438593; DOI=10.1006/viro.1993.1103;
RA Sidhu M.S., Husar W., Cook S.D., Dowling P.C., Udem S.A.;
RT "Canine distemper terminal and intergenic non-protein coding nucleotide
RT sequences: completion of the entire CDV genome sequence.";
RL Virology 193:66-72(1993).
RN [2]
RP SEQUENCE REVISION TO 28; 63-64; 123-126; 351; 457; 468-470; 478 AND 517.
RA Sidhu M.S.;
RL Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate Onderstepoort 1;
RX PubMed=11044118; DOI=10.1128/jvi.74.22.10737-10744.2000;
RA Gassen U., Collins F.M., Duprex W.P., Rima B.K.;
RT "Establishment of a rescue system for canine distemper virus.";
RL J. Virol. 74:10737-10744(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate Onderstepoort 2;
RX PubMed=11413309; DOI=10.1128/jvi.75.14.6418-6427.2001;
RA von Messling V., Zimmer G., Herrler G., Haas L., Cattaneo R.;
RT "The hemagglutinin of canine distemper virus determines tropism and
RT cytopathogenicity.";
RL J. Virol. 75:6418-6427(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 10-523.
RC STRAIN=Isolate Onderstepoort 3;
RX PubMed=3838193; DOI=10.1128/jvi.53.2.684-690.1985;
RA Rozenblatt S., Eizenberg O., Ben-Levy R., Lavie V., Bellini W.J.;
RT "Sequence homology within the morbilliviruses.";
RL J. Virol. 53:684-690(1985).
CC -!- FUNCTION: Encapsidates the genome in a ratio of 1 N per 6
CC ribonucleotides, protecting it from nucleases. The nucleocapsid (NC)
CC has a helical structure. The encapsidated genomic RNA is termed the NC
CC and serves as template for transcription and replication. During
CC replication, encapsidation by N is coupled to RNA synthesis and all
CC replicative products are resistant to nucleases (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC genomic RNA. In nucleocapsid, binds the P protein and thereby positions
CC the polymerase on the template (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host cytoplasm.
CC -!- DOMAIN: Ncore is globular and carries regions required for N self-
CC assembly and RNA-binding. Ntail is an intrinsically disordered
CC monomeric domain (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the paramyxoviruses nucleocapsid family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF014953; AAC26990.1; -; Genomic_RNA.
DR EMBL; AF305419; AAG30916.1; -; Genomic_RNA.
DR EMBL; AF378705; AAK54665.1; -; Genomic_RNA.
DR EMBL; X02000; CAA26032.1; -; mRNA.
DR RefSeq; NP_047201.1; NC_001921.1.
DR SMR; P04865; -.
DR ABCD; P04865; 1 sequenced antibody.
DR GeneID; 1489798; -.
DR KEGG; vg:1489798; -.
DR Proteomes; UP000007634; Genome.
DR Proteomes; UP000161417; Genome.
DR Proteomes; UP000180889; Genome.
DR GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR002021; Paramyx_ncap.
DR Pfam; PF00973; Paramyxo_ncap; 1.
PE 2: Evidence at transcript level;
KW Capsid protein; Helical capsid protein; Host cytoplasm; Reference proteome;
KW Ribonucleoprotein; RNA-binding; Viral nucleoprotein; Virion.
FT CHAIN 1..523
FT /note="Nucleoprotein"
FT /id="PRO_0000142646"
FT REGION 1..400
FT /note="Ncore"
FT /evidence="ECO:0000250"
FT REGION 401..523
FT /note="Ntail"
FT /evidence="ECO:0000250"
FT REGION 422..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 28
FT /note="I -> S (in strain: Isolate Onderstepoort 3)"
FT VARIANT 63..64
FT /note="KI -> NV (in strain: Isolate Onderstepoort 3)"
FT VARIANT 111
FT /note="A -> V (in strain: Isolate Onderstepoort 2)"
FT VARIANT 123..126
FT /note="LDSE -> WILR (in strain: Isolate Onderstepoort 3)"
FT VARIANT 351
FT /note="N -> G (in strain: Isolate Onderstepoort 3)"
FT VARIANT 353..354
FT /note="GR -> ES (in strain: Isolate Onderstepoort 2)"
FT VARIANT 457
FT /note="P -> L (in strain: Isolate Onderstepoort 3)"
FT VARIANT 468..470
FT /note="WSE -> RSG (in strain: Isolate Onderstepoort 3)"
FT VARIANT 478
FT /note="I -> V (in strain: Isolate Onderstepoort 3)"
FT VARIANT 512
FT /note="N -> S (in strain: Isolate Onderstepoort 2)"
FT VARIANT 517
FT /note="S -> N (in strain: Isolate Onderstepoort 1, Isolate
FT Onderstepoort 2 and Isolate Onderstepoort 3)"
FT VARIANT 519
FT /note="K -> R (in strain: Isolate Onderstepoort 2)"
SQ SEQUENCE 523 AA; 58139 MW; B8EAB1D0757DDFBB CRC64;
MASLLKSLTL FKRTRDQPPL ASGSGGAIRG IKHVIIVLIP GDSSIVTRSR LLDRLVRLVG
DPKINGPKLT GILISILSLF VESPGQLIQR IIDDPDVSIK LVEVIPSINS ACGLTFASRG
ASLDSEADEF FKIVDEGSKA QGQLGWLENK DIVDIEVDNA EQFNILLASI LAQIWILLAK
AVTAPDTAAD SEMRRWIKYT QQRRVVGEFR MNKIWLDIVR NRIAEDLSLR RFMVALILDI
KRSPGNKPRI AEMICDIDNY IVEAGLASFI LTIKFGIETM YPALGLHEFS GELTTIESLM
MLYQQMGETA PYMVILENSV QNKFSAGSYP LLWSYAMGVG VELENSMGGL NFGRSYFDPA
YFRLGQEMVR RSAGKVSSAL AAELGITKEE AQLVSEIASK TTEDRTIRAT GPKQSQITFL
HSERSEVANQ QPPTINKRSE NQGGDKYPIH FSDERLPGYT PDVNSSEWSE SRYDTQIIQD
DGNDDDRKSM EAIAKMRMLT KMLSQPGTSE DNSPVYSDKE LLN
