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NCAP_CHAV
ID   NCAP_CHAV               Reviewed;         422 AA.
AC   P11211; Q5IX72; Q5IX76; Q5IX78; Q5IX82; Q5IX86;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   29-SEP-2021, entry version 83.
DE   RecName: Full=Nucleoprotein;
DE            Short=NP;
DE   AltName: Full=Nucleocapsid protein;
DE            Short=Protein N;
GN   Name=N;
OS   Chandipura virus (strain I653514) (CHPV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC   Vesiculovirus.
OX   NCBI_TaxID=11273;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=7198; Phlebotominae (sandflies).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3029973; DOI=10.1016/0042-6822(87)90272-8;
RA   Masters P.S., Banerjee A.K.;
RT   "Sequences of Chandipura virus N and NS genes: evidence for high mutability
RT   of the NS gene within vesiculoviruses.";
RL   Virology 157:298-306(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate CIN0318R, Isolate CIN0327M, Isolate CIN0327R,
RC   Isolate CIN0331M, Isolate CIN0360R, Isolate CIN0360V, and Isolate I653514;
RX   PubMed=15705335; DOI=10.3201/eid1101.040602;
RA   Arankalle V.A., Prabhakar S.S., Madhukar W.A., Hanumaih X.,
RA   Dattatraya P.S., Akhilesh Chandra M.;
RT   "G, N, and P gene-based analysis of Chandipura viruses, India.";
RL   Emerg. Infect. Dis. 11:123-126(2005).
CC   -!- FUNCTION: Encapsidates the genome in a ratio of one N per nine
CC       ribonucleotides, protecting it from nucleases. The encapsidated genomic
CC       RNA is termed the NC and serves as template for transcription and
CC       replication. Replication is dependent on intracellular concentration of
CC       newly synthesized N, termed N(0), which corresponds to the protein not
CC       associated with RNA. In contrast, when associated with RNA, it is
CC       termed N. During replication, encapsidation by N(0) is coupled to RNA
CC       synthesis and all replicative products are resistant to nucleases (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC       genomic RNA. N in nucleocapsid binds the P protein and thereby
CC       positions the polymerase on the template. Interaction of N(0) with the
CC       P protein prevents the uncontrolled aggregation of N(0) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm. Note=The nucleocapsid is
CC       synthesized in the cytoplasm, and is subsequently transported via
CC       microtubules to the cell periphery. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the vesiculovirus nucleocapsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; M16608; AAA48450.1; -; Genomic_RNA.
DR   EMBL; AY614724; AAU81940.1; -; Genomic_RNA.
DR   EMBL; AY614725; AAU81942.1; -; Genomic_RNA.
DR   EMBL; AY614726; AAU81944.1; -; Genomic_RNA.
DR   EMBL; AY614727; AAU81946.1; -; Genomic_RNA.
DR   EMBL; AY614728; AAU81948.1; -; Genomic_RNA.
DR   EMBL; AY614729; AAU81950.1; -; Genomic_RNA.
DR   EMBL; AY614730; AAU81952.1; -; Genomic_RNA.
DR   EMBL; AY614731; AAU81954.1; -; Genomic_RNA.
DR   PIR; A44502; A44502.
DR   SMR; P11211; -.
DR   Proteomes; UP000008448; Genome.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3570.10; -; 1.
DR   Gene3D; 1.10.3610.10; -; 1.
DR   InterPro; IPR000448; Rhabdo_ncapsid.
DR   InterPro; IPR023331; Rhabdovirus_ncapsid_C.
DR   InterPro; IPR023330; Rhabdovirus_ncapsid_N.
DR   InterPro; IPR035961; Rhabdovirus_nucleoprotein-like.
DR   Pfam; PF00945; Rhabdo_ncap; 1.
DR   SUPFAM; SSF140809; SSF140809; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Helical capsid protein; Host cytoplasm; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Viral nucleoprotein; Virion.
FT   CHAIN           1..422
FT                   /note="Nucleoprotein"
FT                   /id="PRO_0000222811"
FT   VARIANT         37
FT                   /note="K -> R (in strain: Isolate CIN0309R, Isolate
FT                   CIN0318R, Isolate CIN0327R, Isolate CIN0327M, Isolate
FT                   CIN0331M, Isolate CIN0360R and Isolate CIN0360V)"
FT   VARIANT         163
FT                   /note="A -> T (in strain: Isolate CIN0309R)"
FT   VARIANT         364
FT                   /note="E -> D (in strain: Isolate CIN0309R, Isolate
FT                   CIN0318R, Isolate CIN0327R and Isolate CIN0327M, Isolate
FT                   CIN0360R and Isolate CIN0360V)"
FT   VARIANT         413
FT                   /note="V -> I (in strain: Isolate CIN0360R and Isolate
FT                   CIN0360V)"
SQ   SEQUENCE   422 AA;  47944 MW;  FADCCF7BF343D235 CRC64;
     MSSQVFCIST GQTVSVCLPA NEDPVEFPGA FFTPNAKKPT VYIKKETDLS LLRSHVYDGI
     KDGSVTVSQI NSYLYMVLKD IREKPDKNWT SFGVELGKKN EPMGIFDLLN VEDVKGKELD
     KKGQDTRLPG DDLWLPTLIF GLYRVSRATQ VEYKKTLMTN LYAQCKLRTK DAEEIVDETA
     EFFNAWANDS NFTKIVAAVD MYFHHFKKSD HAPIRFGTIV SRFKDCAALS TLSHLQKVTG
     LPIEEVFTWV FNKSVQDDLL RMMTPGQEID QADSYMPYLI DMGLSTKSPY SSTKNPSFHF
     WGQLTAFLVK SARAKNALVP VDIAYHELTT AALLFAYAIG RSSELEQRFV LNGKKFTKEK
     DSREDNDTTP PSERNVVVWL AWWEDIKHEI TPDMKAFAKR AVERVGDIRV NSVAEYARKL
     FA
 
 
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