ID   NCAP_DMSVA              Reviewed;         450 AA.
AC   A7WNA9;
DT   04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Nucleoprotein;
DE            Short=NP;
DE   AltName: Full=Nucleocapsid protein;
DE            Short=Protein N;
GN   Name=N;
OS   Drosophila melanogaster sigma virus (isolate Drosophila/USA/AP30/2005)
OS   (DMelSV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC   Sigmavirus.
OX   NCBI_TaxID=666363;
OH   NCBI_TaxID=7227; Drosophila melanogaster (Fruit fly).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=AP30;
RX   PubMed=17725574; DOI=10.1111/j.1365-294x.2007.03460.x;
RA   Carpenter J.A., Obbard D.J., Maside X., Jiggins F.M.;
RT   "The recent spread of a vertically transmitted virus through populations of
RT   Drosophila melanogaster.";
RL   Mol. Ecol. 16:3947-3954(2007).
CC   -!- FUNCTION: Encapsidates the genome, protecting it from nucleases. The
CC       encapsidated genomic RNA is termed the NC and serves as template for
CC       transcription and replication. Nucleocapsid assembly is concommitant
CC       with replication, therefore viral replication depends on the
CC       intracellular concentration of free N, termed N(0). All replicative
CC       products are resistant to nucleases. {ECO:0000250|UniProtKB:P03521}.
CC   -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC       genomic RNA. N in nucleocapsid binds the P protein and thereby
CC       positions the polymerase on the template. Interaction of N(0) with the
CC       P protein prevents the uncontrolled aggregation of N(0).
CC       {ECO:0000250|UniProtKB:P03521}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm. Note=The nucleocapsid is
CC       synthesized in the cytoplasm, and is subsequently transported via
CC       microtubules to the cell periphery. {ECO:0000250|UniProtKB:P03521}.
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DR   EMBL; AM689309; CAM84584.2; -; Genomic_RNA.
DR   RefSeq; YP_003126908.1; NC_013135.1.
DR   SMR; A7WNA9; -.
DR   PRIDE; A7WNA9; -.
DR   GeneID; 8363507; -.
DR   KEGG; vg:8363507; -.
DR   Proteomes; UP000029768; Genome.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3570.10; -; 1.
DR   Gene3D; 1.10.3610.10; -; 1.
DR   InterPro; IPR000448; Rhabdo_ncapsid.
DR   InterPro; IPR023331; Rhabdovirus_ncapsid_C.
DR   InterPro; IPR023330; Rhabdovirus_ncapsid_N.
DR   InterPro; IPR035961; Rhabdovirus_nucleoprotein-like.
DR   Pfam; PF00945; Rhabdo_ncap; 1.
DR   SUPFAM; SSF140809; SSF140809; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Helical capsid protein; Host cytoplasm; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Viral nucleoprotein; Viral RNA replication;
KW   Virion.
FT   CHAIN           1..450
FT                   /note="Nucleoprotein"
FT                   /id="PRO_0000432067"
SQ   SEQUENCE   450 AA;  50789 MW;  6F08B7CEB847D465 CRC64;
     MEQTRLYHID TKTEFVVRTP EFTSPVEYPF TWFTNNKTKP LFKISVMADC SLETARVAAL
     EFLMGEKVPP SHVIDYIYEF CKTMTQELDT NWESYGQVIG KKGDTVTPLS LLHIMISQDT
     RKYTPKNPRL LTDEVDIYLV GNLLCSYRYN KTHEKMQTAY GTKVASILAP FSTHDTQNIR
     IATFLTNSKS LVDHPNFEIM ASAIDMFLER FPSHGMGKLR FGTIGLRYQG CSGLVDLTYL
     KQILKKPGLA DAIKWLFAGC LVSEVFQMMI NHQDEIDVKH SYFPYMIGFK ISNKSPFSAG
     SNPSIHTLVH LIGSLLGSPR SINAIMIEYG VISDIVVNAA IVFFAHRSDI GAKVRFGERG
     VMNEIHQEED AARQRKRSAA AGGLPAVQPT DPRGWLAEYQ DRDYKFTQSE VDDLNKVIQG
     IPQVRAGTVG EWVKLNFISN LPKGFDVTRV