NCAP_DUVV
ID NCAP_DUVV Reviewed; 451 AA.
AC Q66453; A3QU35; O41853; Q49AU8; Q49AU9; Q8QPB9; Q8QPC0; Q8QPC1;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 23-FEB-2022, entry version 74.
DE RecName: Full=Nucleoprotein;
DE Short=NP;
DE AltName: Full=Nucleocapsid protein;
DE Short=Protein N;
GN Name=N;
OS Duvenhage virus (DUVV).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC Lyssavirus.
OX NCBI_TaxID=38767;
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=40674; Mammalia.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate 86132AS;
RX PubMed=7778285; DOI=10.1006/viro.1995.1285;
RA Kissi B., Tordo N., Bourhy H.;
RT "Genetic polymorphism in the rabies virus nucleoprotein gene.";
RL Virology 209:526-537(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate 94286, and Isolate N86132;
RX PubMed=16051841; DOI=10.1128/jvi.79.16.10487-10497.2005;
RA Davis P.L., Holmes E.C., Larrous F., Van der Poel W.H., Tjornehoj K.,
RA Alonso W.J., Bourhy H.;
RT "Phylogeography, population dynamics, and molecular evolution of European
RT bat lyssaviruses.";
RL J. Virol. 79:10487-10497(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-133.
RC STRAIN=94286SA;
RX PubMed=9292021; DOI=10.1099/0022-1317-78-9-2319;
RA Amengual B., Whitby J.E., King A., Cobo J.S., Bourhy H.;
RT "Evolution of European bat lyssaviruses.";
RL J. Gen. Virol. 78:2319-2328(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-135.
RC STRAIN=Isolate Bat/South Africa/Rv139, Isolate Bat/Zimbabwe/Rv131, and
RC Isolate Human/South Africa/Rv6;
RX PubMed=12417947; DOI=10.1007/s00705-002-0877-4;
RA Johnson N., McElhinney L.M., Smith J., Lowings P., Fooks A.R.;
RT "Phylogenetic comparison of the genus Lyssavirus using distal coding
RT sequences of the glycoprotein and nucleoprotein genes.";
RL Arch. Virol. 147:2111-2123(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 12-170.
RC STRAIN=SPU94.06;
RX PubMed=17326954; DOI=10.3201/eid1212.060764;
RA Paweska J.T., Blumberg L.H., Liebenberg C., Hewlett R.H., Grobbelaar A.A.,
RA Leman P.A., Croft J.E., Nel L.H., Nutt L., Swanepoel R.;
RT "Fatal human infection with rabies-related Duvenhage virus, South Africa.";
RL Emerg. Infect. Dis. 12:1965-1967(2006).
CC -!- FUNCTION: Encapsidates the genome, protecting it from nucleases. If
CC expressed without protein P it binds non-specifically RNA and therefore
CC can bind it's own mRNA. Interaction with protein P abolishes any non-
CC specific RNA binding, and prevents phosphorylation. The soluble N-P
CC complex encapsidates specifically the genomic RNA, with protein N
CC protecting the genome like a pearl necklace. The encapsidated genomic
CC RNA is termed the nucleocapsid (NC) and serves as template for viral
CC transcription and replication. Protein N binds protein P in the NC
CC through a different interaction, and can be phosphorylated. Subsequent
CC viral replication is dependent on intracellular concentration of newly
CC synthesized protein N. During replication, encapsidation by protein N
CC is coupled to RNA synthesis and all replicative products are resistant
CC to nucleases (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC genomic RNA (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm {ECO:0000250}.
CC -!- PTM: Phosphorylated by host. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the lyssavirus nucleocapsid protein family.
CC {ECO:0000305}.
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DR EMBL; U22848; AAA80285.1; -; Genomic_RNA.
DR EMBL; AY996323; AAY53552.1; -; Genomic_RNA.
DR EMBL; AY996324; AAY53553.1; -; Genomic_RNA.
DR EMBL; U89483; AAB71129.1; -; Genomic_RNA.
DR EMBL; AY062079; AAL47619.1; -; Genomic_RNA.
DR EMBL; AY062080; AAL47620.1; -; Genomic_RNA.
DR EMBL; AY062081; AAL47621.1; -; Genomic_RNA.
DR EMBL; DQ676932; ABG74925.1; -; Genomic_RNA.
DR RefSeq; YP_007641402.1; NC_020810.1.
DR SMR; Q66453; -.
DR GeneID; 14857942; -.
DR KEGG; vg:14857942; -.
DR GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3570.10; -; 1.
DR Gene3D; 1.10.3610.10; -; 1.
DR InterPro; IPR000448; Rhabdo_ncapsid.
DR InterPro; IPR023331; Rhabdovirus_ncapsid_C.
DR InterPro; IPR023330; Rhabdovirus_ncapsid_N.
DR InterPro; IPR035961; Rhabdovirus_nucleoprotein-like.
DR Pfam; PF00945; Rhabdo_ncap; 1.
DR SUPFAM; SSF140809; SSF140809; 1.
PE 3: Inferred from homology;
KW Capsid protein; Helical capsid protein; Host cytoplasm; Phosphoprotein;
KW Ribonucleoprotein; RNA-binding; Superantigen; Viral nucleoprotein; Virion.
FT CHAIN 1..451
FT /note="Nucleoprotein"
FT /id="PRO_0000299092"
FT MOD_RES 389
FT /note="Phosphoserine; by host CK2"
FT /evidence="ECO:0000250"
FT VARIANT 107
FT /note="T -> M (in strain: Isolate Human/South Africa/Rv6)"
FT VARIANT 127
FT /note="D -> E (in strain: Isolate 86132AS and Isolate
FT 94286)"
SQ SEQUENCE 451 AA; 50696 MW; 882FA62B88FF192B CRC64;
MDAERIVFKV RNQLVSVKPE VISDQYEYKY PAITDKKKPS ITLGRAPDLK TAYKSILSGM
NAAKLDPDDV CSYLAGAMIL FEGVCPEDWV SYGIHIARKG DKITPATLVD IVRTNTEGNW
AQTGGQDLTR DPTISEHASL VGLLLCLYRL SKIVGQNTGN YKTNVADRME QIFETAPFVK
IVEHHTLMTT HKMCANWSTI PNFRFLAGTY DMFFSRVDHL YSAIRVGTVV TAYEDCSGLV
SFTGFIKQIN LTAREAILYF FHKNFEEEIK RMFEPGQETA VPHSYFIHFR SLGLSGKSPY
SSNAVGHVFN LIHFVGCYMG QIRSLNATVI QSCAPHEMSV LGGYLGEEFF GKGTFERRFF
RDEKELQDYE EAEATKIEAA LADDGTVNSD DEDFFSGDTR SPEAVYTRIM MNGGRLKGAH
IRRYVSVSSS HQARPNSFAE FLNKTYSSDS R
