ID   NCAP_HIRRV              Reviewed;         392 AA.
AC   Q9QL89; Q82036;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   23-FEB-2022, entry version 64.
DE   RecName: Full=Nucleoprotein;
DE            Short=NP;
DE   AltName: Full=Nucleocapsid protein;
DE            Short=Protein N;
GN   Name=N;
OS   Hirame rhabdovirus (strain Korea/CA 9703/1997) (HIRRV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Gammarhabdovirinae;
OC   Novirhabdovirus.
OX   NCBI_TaxID=453457;
OH   NCBI_TaxID=72011; Acanthopagrus schlegelii (Black porgy).
OH   NCBI_TaxID=8255; Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus).
OH   NCBI_TaxID=61084; Plecoglossus altivelis (Ayu).
OH   NCBI_TaxID=160818; Sebastes inermis (Dark-banded rockfish).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15567027; DOI=10.1016/j.virusres.2004.06.004;
RA   Kim D.H., Oh H.K., Eou J.I., Seo H.J., Kim S.K., Oh M.J., Nam S.W.,
RA   Choi T.J.;
RT   "Complete nucleotide sequence of the hirame rhabdovirus, a pathogen of
RT   marine fish.";
RL   Virus Res. 107:1-9(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 144-392.
RC   STRAIN=8401-H;
RA   Nishizawa T.;
RL   Submitted (FEB-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Encapsidates the genome, protecting it from nucleases. If
CC       expressed without protein P it binds non-specifically RNA and therefore
CC       can bind it's own mRNA. Interaction with protein P abolishes any non-
CC       specific RNA binding, and prevents phosphorylation. The soluble N-P
CC       complex encapsidates specifically the genomic RNA, with protein N
CC       protecting the genome like a pearl necklace. The encapsidated genomic
CC       RNA is termed the nucleocapsid (NC) and serves as template for viral
CC       transcription and replication. Protein N binds protein P in the NC
CC       through a different interaction, and can be phosphorylated. Subsequent
CC       viral replication is dependent on intracellular concentration of newly
CC       synthesized protein N. During replication, encapsidation by protein N
CC       is coupled to RNA synthesis and all replicative products are resistant
CC       to nucleases (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC       genomic RNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the novirhabdovirus nucleocapsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; D45422; BAA08261.1; -; Genomic_RNA.
DR   EMBL; AF104985; AAF14116.1; -; Genomic_RNA.
DR   Proteomes; UP000008118; Genome.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004902; Rhabdo_ncap_2.
DR   Pfam; PF03216; Rhabdo_ncap_2; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Helical capsid protein; Host cytoplasm; Phosphoprotein;
KW   Reference proteome; Ribonucleoprotein; RNA-binding; Viral nucleoprotein;
KW   Virion.
FT   CHAIN           1..392
FT                   /note="Nucleoprotein"
FT                   /id="PRO_0000297610"
FT   REGION          345..392
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        366..392
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   392 AA;  42466 MW;  C5A282238FC7A638 CRC64;
     MANLKEEFAG LRGVKGGALE DSGTEYDPTK INLTLYGTDK LYTLAIIKRA VSQVGGSQTN
     KALGILCAFV TSENNPDMTD AAVKLLVDMR FKVDVVPVDD RLGDNLDDPN SKLAEVLTEE
     NMVDLVKGLL FTCALMVKYD VDKMATYCQQ KLERLANSQG LNELTLISTS RAVLARIGAA
     VRPGQKLTKA IYGIILINLM DPATAARAKA LCAMRLSGTG MTMVGLFNQA SKNLGAPPAD
     LLEDLCMKSI IDSARRIVKL MRIVADVEDM TAKYAIMMSR MLGDGYFKSY GINENSRITC
     ILMNINEQYD EGTTGGLAGV RVSPPFRKLA TEIARLLVKK YDGNGSAGPG ASDLVRQAEQ
     AAQETEGEDD KYDEEGEEDG GEGEGGEDEE YY