ID   NCAP_HMPVC              Reviewed;         394 AA.
AC   Q6WBA1;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   02-JUN-2021, entry version 41.
DE   RecName: Full=Nucleoprotein;
DE            Short=Protein N;
DE   AltName: Full=Nucleocapsid protein;
GN   Name=N;
OS   Human metapneumovirus (strain CAN97-83) (HMPV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Pneumoviridae; Metapneumovirus.
OX   NCBI_TaxID=694067;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=14592754; DOI=10.1016/s0042-6822(03)00528-2;
RA   Biacchesi S., Skiadopoulos M.H., Boivin G., Hanson C.T., Murphy B.R.,
RA   Collins P.L., Buchholz U.J.;
RT   "Genetic diversity between human metapneumovirus subgroups.";
RL   Virology 315:1-9(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16306583; DOI=10.1128/jvi.79.24.15114-15122.2005;
RA   Pham Q.N., Biacchesi S., Skiadopoulos M.H., Murphy B.R., Collins P.L.,
RA   Buchholz U.J.;
RT   "Chimeric recombinant human metapneumoviruses with the nucleoprotein or
RT   phosphoprotein open reading frame replaced by that of avian metapneumovirus
RT   exhibit improved growth in vitro and attenuation in vivo.";
RL   J. Virol. 79:15114-15122(2005).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=28978704; DOI=10.1128/jvi.01282-17;
RA   Cifuentes-Munoz N., Branttie J., Slaughter K.B., Dutch R.E.;
RT   "Human Metapneumovirus Induces Formation of Inclusion Bodies for Efficient
RT   Genome Replication and Transcription.";
RL   J. Virol. 91:0-0(2017).
CC   -!- FUNCTION: Encapsidates the viral RNA genome by forming a left-handed
CC       helical nucleocapsid that protects the RNA from nucleases. RNA
CC       replication depends on the availability of soluble nucleoprotein. The
CC       encapsidated genomic RNA is termed the NC and serves as template for
CC       transcription and replication. {ECO:0000250|UniProtKB:P03418}.
CC   -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC       genomic RNA. Interacts with the phosphoprotein P. When in a monomeric
CC       RNA-free form, interacts with the phosphoprotein (via N-terminus).
CC       Interacts with protein M2-1; this interaction allows the association of
CC       nucleocapsid with the matrix protein. {ECO:0000250|UniProtKB:P03418}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:P03418}. Host
CC       cytoplasm {ECO:0000269|PubMed:28978704}. Note=Localizes in cytoplasmic
CC       inclusion bodies. {ECO:0000269|PubMed:28978704}.
CC   -!- SIMILARITY: Belongs to the paramyxoviruses nucleocapsid family.
CC       {ECO:0000305}.
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DR   EMBL; AY297749; AAQ67692.1; -; Genomic_RNA.
DR   RefSeq; YP_012605.1; NC_004148.2.
DR   SMR; Q6WBA1; -.
DR   PRIDE; Q6WBA1; -.
DR   Proteomes; UP000001398; Genome.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004930; Pneumo_ncap.
DR   Pfam; PF03246; Pneumo_ncap; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Helical capsid protein; Host cytoplasm; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Viral nucleoprotein; Virion.
FT   CHAIN           1..394
FT                   /note="Nucleoprotein"
FT                   /id="PRO_0000394805"
SQ   SEQUENCE   394 AA;  43538 MW;  A9D91AC924CA2551 CRC64;
     MSLQGIHLSD LSYKHAILKE SQYTIKRDVG TTTAVTPSSL QQEITLLCGE ILYAKHADYK
     YAAEIGIQYI STALGSERVQ QILRNSGSEV QVVLTRTYSL GKVKNNKGED LQMLDIHGVE
     KSWVEEIDKE ARKTMATLLK ESSGNIPQNQ RPSAPDTPII LLCVGALIFT KLASTIEVGL
     ETTVRRANRV LSDALKRYPR MDIPKIARSF YDLFEQKVYY RSLFIEYGKA LGSSSTGSKA
     ESLFVNIFMQ AYGAGQTMLR WGVIARSSNN IMLGHVSVQA ELKQVTEVYD LVREMGPESG
     LLHLRQSPKA GLLSLANCPN FASVVLGNAS GLGIIGMYRG RVPNTELFSA AESYAKSLKE
     SNKINFSSLG LTDEEKEAAE HFLNVSDDSQ NDYE