NCAP_ISFV
ID NCAP_ISFV Reviewed; 423 AA.
AC Q5K2K7;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Nucleoprotein;
DE Short=NP;
DE AltName: Full=Nucleocapsid protein;
DE Short=Protein N;
GN Name=N;
OS Isfahan virus (ISFV).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC Vesiculovirus.
OX NCBI_TaxID=290008;
OH NCBI_TaxID=10045; Gerbillinae (gerbils).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=29031; Phlebotomus papatasi (Sandfly).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=15614433; DOI=10.1007/s00705-004-0452-2;
RA Marriott A.C.;
RT "Complete genome sequences of Chandipura and Isfahan vesiculoviruses.";
RL Arch. Virol. 150:671-680(2005).
CC -!- FUNCTION: Encapsidates the genome in a ratio of one N per nine
CC ribonucleotides, protecting it from nucleases. The encapsidated genomic
CC RNA is termed the NC and serves as template for transcription and
CC replication. Replication is dependent on intracellular concentration of
CC newly synthesized N, termed N(0), which corresponds to the protein not
CC associated with RNA. In contrast, when associated with RNA, it is
CC termed N. During replication, encapsidation by N(0) is coupled to RNA
CC synthesis and all replicative products are resistant to nucleases (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC genomic RNA. N in nucleocapsid binds the P protein and thereby
CC positions the polymerase on the template. Interaction of N(0) with the
CC P protein prevents the uncontrolled aggregation of N(0) (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm. Note=The nucleocapsid is
CC synthesized in the cytoplasm, and is subsequently transported via
CC microtubules to the cell periphery. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the vesiculovirus nucleocapsid protein family.
CC {ECO:0000305}.
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DR EMBL; AJ810084; CAH17544.1; -; Genomic_RNA.
DR RefSeq; YP_007641382.1; NC_020806.1.
DR SMR; Q5K2K7; -.
DR PRIDE; Q5K2K7; -.
DR GeneID; 14857918; -.
DR KEGG; vg:14857918; -.
DR Proteomes; UP000204017; Genome.
DR GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3570.10; -; 1.
DR Gene3D; 1.10.3610.10; -; 1.
DR InterPro; IPR000448; Rhabdo_ncapsid.
DR InterPro; IPR023331; Rhabdovirus_ncapsid_C.
DR InterPro; IPR023330; Rhabdovirus_ncapsid_N.
DR InterPro; IPR035961; Rhabdovirus_nucleoprotein-like.
DR Pfam; PF00945; Rhabdo_ncap; 1.
DR SUPFAM; SSF140809; SSF140809; 1.
PE 3: Inferred from homology;
KW Capsid protein; Helical capsid protein; Host cytoplasm; Ribonucleoprotein;
KW RNA-binding; Viral nucleoprotein; Virion.
FT CHAIN 1..423
FT /note="Nucleoprotein"
FT /id="PRO_0000287266"
SQ SEQUENCE 423 AA; 48185 MW; 28CC29306CBE86FC CRC64;
MTSVVKRIAT GSSVLAVLPA NEDPVEFPGD YFLQNPGKIR VCINRKLDVA TLRQYVYEGL
KNGDVHVCHI NSYLYQVLKD TRDEAQSDWI SFGVSLAVKG GIVSVFDTLM IEDYRGEAPD
GRKCDGRTID DDKWLPMLIL GLYRVSRATQ EDYKKSLLQK LYAQCKLRSP QAEELVEDAA
EFYEVWSNDS NFLKLVAAID MFFHKFKNHA DAGLRWGTIV SRFKDCAALA TLSHVQKVTG
LSIKEVFTWV LNKSVEDELC RMMKERQEVD KADSYMPYLI DFGISTKSPY SSVKNPCFHF
WGQLTALLVH SHRAKNARVP EDIPYNELTT AAWLFAYAMG RSSGLEQRFT TDDSYYQEDE
DINKGLGVKA PTTRDVQMWL AWWSDIGKVP TQDMETFARR EVLGLTEIRS KTIGEYAKKT
FSV
