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NCAP_LNYV3
ID   NCAP_LNYV3              Reviewed;         459 AA.
AC   Q86134; Q4W390;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   23-FEB-2022, entry version 68.
DE   RecName: Full=Nucleoprotein;
DE            Short=NP;
DE   AltName: Full=Nucleocapsid protein;
DE            Short=Protein N;
GN   Name=N;
OS   Lettuce necrotic yellows virus (isolate 318) (LNYV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Betarhabdovirinae;
OC   Cytorhabdovirus.
OX   NCBI_TaxID=928304;
OH   NCBI_TaxID=43191; Embergeria.
OH   NCBI_TaxID=4236; Lactuca sativa (Garden lettuce).
OH   NCBI_TaxID=43208; Reichardia tingitana.
OH   NCBI_TaxID=255580; Sonchus hydrophilus.
OH   NCBI_TaxID=50207; Sonchus oleraceus (Common sowthistle).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8030210; DOI=10.1006/viro.1994.1438;
RA   Wetzel T., Dietzgen R.G., Geering A.D., Dale J.L.;
RT   "Analysis of the nucleocapsid gene of lettuce necrotic yellows
RT   rhabdovirus.";
RL   Virology 202:1054-1057(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate 2;
RX   PubMed=15824884; DOI=10.1007/s00705-005-0528-7;
RA   Callaghan B., Dietzgen R.G.;
RT   "Nucleocapsid gene variability reveals two subgroups of Lettuce necrotic
RT   yellows virus.";
RL   Arch. Virol. 150:1661-1667(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16313992; DOI=10.1016/j.virusres.2005.10.024;
RA   Dietzgen R.G., Callaghan B., Wetzel T., Dale J.L.;
RT   "Completion of the genome sequence of Lettuce necrotic yellows virus, type
RT   species of the genus Cytorhabdovirus.";
RL   Virus Res. 118:16-22(2006).
CC   -!- FUNCTION: Encapsidates the genome, protecting it from nucleases. If
CC       expressed without protein P it binds non-specifically RNA and therefore
CC       can bind it's own mRNA. Interaction with protein P abolishes any non-
CC       specific RNA binding, and prevents phosphorylation. The soluble N-P
CC       complex encapsidates specifically the genomic RNA, with protein N
CC       protecting the genome like a pearl necklace. The encapsidated genomic
CC       RNA is termed the nucleocapsid (NC) and serves as template for viral
CC       transcription and replication. Protein N binds protein P in the NC
CC       through a different interaction, and can be phosphorylated. Subsequent
CC       viral replication is dependent on intracellular concentration of newly
CC       synthesized protein N. During replication, encapsidation by protein N
CC       is coupled to RNA synthesis and all replicative products are resistant
CC       to nucleases (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC       genomic RNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytorhabdovirus nucleocapsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; L30103; AAA47287.1; -; Genomic_RNA.
DR   EMBL; AJ746191; CAG34083.1; -; Genomic_RNA.
DR   EMBL; AJ867584; CAI30421.1; -; Genomic_RNA.
DR   RefSeq; YP_425087.1; NC_007642.1.
DR   GeneID; 3844364; -.
DR   KEGG; vg:3844364; -.
DR   Proteomes; UP000008592; Genome.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004902; Rhabdo_ncap_2.
DR   Pfam; PF03216; Rhabdo_ncap_2; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Helical capsid protein; Host cytoplasm; Phosphoprotein;
KW   Reference proteome; Ribonucleoprotein; RNA-binding; Viral nucleoprotein;
KW   Virion.
FT   CHAIN           1..459
FT                   /note="Nucleoprotein"
FT                   /id="PRO_0000297612"
FT   VARIANT         131
FT                   /note="P -> T (in strain: Isolate 2)"
SQ   SEQUENCE   459 AA;  50679 MW;  BCE34D3CB971F57C CRC64;
     MTTSAEKLAK LEQLRKERAA VIQKPTTQVS SEPVVTEKPR VRNTAYDSLA GVTIGKRASR
     KWSDADIKSI PIYDVHQVPA AQVIALGKDL LTQIQNNSVN TVTVDYCLVL AVSIPKPAMT
     SFEHLLTPPS PEQGTRLDFT QPQAGVSNRS GLTAIEKMTL NATRKNLLTE TDEEKRARYE
     AIIKKMEDQE AGLGTSKATV VTSETEAAAY GFLAATLLKL YAKSTESYVA GLAQIRNRFA
     AWYDCPKAVL DAFQPTEAAL VSLRAAFARR PEVLSTWTLW VAVNENRTPG LLVTQQGLLN
     YLACQQFAYP GMHAYTLLIE IHEHTGMKFS DLLVEMDCPA TRAGVREALE LIRDYEITKD
     HPKRTTYFRY ARNWDPKYFG ALQSTECKTL VYVAASVSKK VSAQGANGDP MEIFAIKNLD
     ATIKARLDPV AENMAGKILD QMLMDEMSGA SWATKASTQ
 
 
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