NCAP_MMVR
ID NCAP_MMVR Reviewed; 447 AA.
AC Q6E0X1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 02-JUN-2021, entry version 53.
DE RecName: Full=Nucleoprotein;
DE Short=NP;
DE AltName: Full=Nucleocapsid protein;
DE Short=Protein N;
GN Name=N;
OS Maize mosaic virus (isolate Maize/United States/Reed/2005) (MMV).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Rhabdoviridae; Nucleorhabdovirus.
OX NCBI_TaxID=928305;
OH NCBI_TaxID=300124; Rottboellia.
OH NCBI_TaxID=4554; Setaria.
OH NCBI_TaxID=4558; Sorghum bicolor (Sorghum) (Sorghum vulgare).
OH NCBI_TaxID=4577; Zea mays (Maize).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=16005085; DOI=10.1016/j.jviromet.2005.05.013;
RA Reed S.E., Tsai C.W., Willie K.J., Redinbaugh M.G., Hogenhout S.A.;
RT "Shotgun sequencing of the negative-sense RNA genome of the rhabdovirus
RT Maize mosaic virus.";
RL J. Virol. Methods 129:91-96(2005).
CC -!- FUNCTION: Encapsidates the genome, protecting it from nucleases. If
CC expressed without protein P it binds non-specifically RNA and therefore
CC can bind it's own mRNA. Interaction with protein P abolishes any non-
CC specific RNA binding, and prevents phosphorylation. The soluble N-P
CC complex encapsidates specifically the genomic RNA, with protein N
CC protecting the genome like a pearl necklace. The encapsidated genomic
CC RNA is termed the nucleocapsid (NC) and serves as template for viral
CC transcription and replication. Protein N binds protein P in the NC
CC through a different interaction, and can be phosphorylated. Subsequent
CC viral replication is dependent on intracellular concentration of newly
CC synthesized protein N. During replication, encapsidation by protein N
CC is coupled to RNA synthesis and all replicative products are resistant
CC to nucleases (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC genomic RNA (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the nucleorhabdovirus nucleocapsid protein
CC family. {ECO:0000305}.
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DR EMBL; AY618418; AAT66752.1; -; Genomic_RNA.
DR RefSeq; YP_052850.1; NC_005975.1.
DR GeneID; 2886118; -.
DR KEGG; vg:2886118; -.
DR Proteomes; UP000008593; Genome.
DR GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR InterPro; IPR004902; Rhabdo_ncap_2.
DR Pfam; PF03216; Rhabdo_ncap_2; 1.
PE 3: Inferred from homology;
KW Capsid protein; Helical capsid protein; Host cytoplasm; Reference proteome;
KW Ribonucleoprotein; RNA-binding; Superantigen; Viral nucleoprotein; Virion.
FT CHAIN 1..447
FT /note="Nucleoprotein"
FT /id="PRO_0000299201"
FT REGION 401..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 405..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 447 AA; 48604 MW; 710C70C9FD3739C2 CRC64;
MANINIPDDL VSKYSEDVKD LTQKAGSIPS SKSLIPQTAF TPDELRRSLK FWQVTTKVAA
TVASDWTNLA TALTNGTFSA THLRTLCELA FNLKAPTGTG TIFIHEIADP WKGCIDANAP
DTVAIPATDS DVNMSTVSSG STASGTEDAE VKMKAISFLC CTLLRLSVKE PSHIMQAINS
IRQRFGSLYG VSSPTLNSVT FNRSQLSRIK QGIETYPSAR GTVFYYTRYA DATHGYTTKE
YGICRFLLFQ HLELEGMHIY KMLLALLGEW STVPIGLLLT WIRNPRSKLA INEIVKIVKE
LDKPEVDKGW KYARMVNNTF FLDLSSRRNT YLCAVLASLN KKNVPQGSGE YADPTNIAVI
KNMDQSVKSQ VATDVTLIER IYEKYLVSAG GDEAGTAYAL SRGVKRSSPP SQEGGQSGQS
GGTPMEVDGA SGRGAAGPAP KKTRSGL
