ID   NCAP_MUMPM              Reviewed;         549 AA.
AC   P21186; Q783W2;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   02-JUN-2021, entry version 81.
DE   RecName: Full=Nucleoprotein;
DE   AltName: Full=Nucleocapsid protein;
DE            Short=NP;
DE            Short=Protein N;
GN   Name=N; Synonyms=NP;
OS   Mumps virus (strain Miyahara vaccine) (MuV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Rubulavirinae;
OC   Orthorubulavirus; Mumps orthorubulavirus.
OX   NCBI_TaxID=11171;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1693800; DOI=10.1016/0042-6822(90)90466-5;
RA   Tanabayashi K., Takeuchi K., Hishiyama M., Yamada A., Tsurudome M., Ito Y.,
RA   Sugiura A.;
RT   "Nucleotide sequence of the leader and nucleocapsid protein gene of mumps
RT   virus and epitope mapping with the in vitro expressed nucleocapsid
RT   protein.";
RL   Virology 177:124-130(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1585659; DOI=10.1016/0042-6822(92)90555-4;
RA   Okazaki K., Tanabayashi K., Takeuchi K., Hishiyama M., Okazaki K.,
RA   Yamada A.;
RT   "Molecular cloning and sequence analysis of the mumps virus gene encoding
RT   the L protein and the trailer sequence.";
RL   Virology 188:926-930(1992).
CC   -!- FUNCTION: Encapsidates the genome, protecting it from nucleases. The
CC       nucleocapsid (NC) has a helical structure, approximately 20 nm in
CC       diameter, with a hollow central cavity approximately 5 nm in diameter.
CC       The encapsidated genomic RNA is termed the NC and serves as template
CC       for transcription and replication. During replication, encapsidation by
CC       N is coupled to RNA synthesis and all replicative products are
CC       resistant to nucleases (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC       genomic RNA. In nucleocapsid, binds the P protein and thereby positions
CC       the polymerase on the template (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host cytoplasm.
CC   -!- DOMAIN: Ncore is globular and carries regions required for N self-
CC       assembly and RNA-binding. Ntail is an intrinsically disordered
CC       monomeric domain (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the paramyxoviruses nucleocapsid family.
CC       {ECO:0000305}.
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DR   EMBL; M37750; AAA46619.1; -; Genomic_RNA.
DR   EMBL; AB040874; BAA94384.1; -; Genomic_RNA.
DR   PIR; A35314; VHNZMY.
DR   SMR; P21186; -.
DR   Proteomes; UP000002331; Genome.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR002021; Paramyx_ncap.
DR   Pfam; PF00973; Paramyxo_ncap; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Helical capsid protein; Host cytoplasm; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Viral nucleoprotein; Virion.
FT   CHAIN           1..549
FT                   /note="Nucleoprotein"
FT                   /id="PRO_0000142661"
FT   REGION          1..400
FT                   /note="Ncore"
FT                   /evidence="ECO:0000250"
FT   REGION          1..398
FT                   /note="P protein-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          1..375
FT                   /note="Homomultimerization"
FT                   /evidence="ECO:0000250"
FT   REGION          401..549
FT                   /note="Ntail"
FT                   /evidence="ECO:0000250"
FT   REGION          409..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          437..467
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          517..549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   549 AA;  61366 MW;  BD06298800BF1AC2 CRC64;
     MSSVLKAFER FTIEQELQDR GEEGSIPPET LKSAVKVFVI NTPNPTTRYH MLNFCLRIIC
     SQNARASHRV GALITLFSLP SAGMQNHIRL ADRSPEAQIE RCEIDGFEPG TYRLIPNARA
     NLTANEIAAY ALLADDLPPT INNGTPYVHA DVEGQPCDEI EQFLDRCYSV LIQAWVMVCK
     CMTAYDQPAG SADRRFAKYQ QQGRLEARYM LQPEAQRLIQ TAIRKSLVVR QYLTFELQLA
     RRQGLLSNRY YAMVGDIGKY IENSGLTAFF LTLKYALGTK WSPLSLAAFT GELTKLRSLM
     MLYRDLGEQA RYLALLEAPQ IMDFAPGGYP LIFSYAMGVG TVLDVQMRNY TYARPFLNGY
     YFQIGVETAR RQQGTVDNRV ADDLGLTPEQ RTEVTQLIDR LARGRGAGIP GGPVNPFVPP
     VQQQQPAAAY EDIPALEESD DDGDEDGGAG FQNGAQAPAA RQGGQNDFRV QPLQDPIQAQ
     LFMPLYPQVS NIPNHQNHQI NRIGGMEHQD LLRYNENGDS QQDARGEHGN TFPNNPNQNA
     QSQVGDWDE