NCAP_NDVB
ID NCAP_NDVB Reviewed; 489 AA.
AC P09459; O72641;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 2.
DT 02-JUN-2021, entry version 71.
DE RecName: Full=Nucleoprotein;
DE AltName: Full=Nucleocapsid protein;
DE Short=NP;
DE Short=Protein N;
GN Name=N; Synonyms=NP;
OS Newcastle disease virus (strain Beaudette C/45) (NDV).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Paramyxoviridae; Avulavirinae;
OC Orthoavulavirus; Avian orthoavulavirus 1.
OX NCBI_TaxID=11178;
OH NCBI_TaxID=9031; Gallus gallus (Chicken).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=9780047; DOI=10.1099/0022-1317-79-10-2419;
RA Krishnamurthy S., Samal S.K.;
RT "Nucleotide sequences of the trailer, nucleocapsid protein gene and
RT intergenic regions of Newcastle disease virus strain Beaudette C and
RT completion of the entire genome sequence.";
RL J. Gen. Virol. 79:2419-2424(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Texas GB;
RX PubMed=10737642; DOI=10.2307/1592505;
RA Ward M.D., Fuller F.J., Mehrotra Y., De Buysscher E.V.;
RT "Nucleotide sequence and vaccinia expression of the nucleoprotein of a
RT highly virulent, neurotropic strain of Newcastle disease virus.";
RL Avian Dis. 44:34-44(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=11864745; DOI=10.1016/s0168-1702(01)00427-0;
RA Seal B.S., Crawford J.M., Sellers H.S., Locke D.P., King D.J.;
RT "Nucleotide sequence analysis of the Newcastle disease virus nucleocapsid
RT protein gene and phylogenetic relationships among the Paramyxoviridae.";
RL Virus Res. 83:119-129(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=AQI-ND026;
RA Wang Z., Bao J., Chen J., Zhen D., Chen Y., Song C.;
RT "Genomic sequence for isolate AQI-ND026 of Newcastle disease virus.";
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA] OF 1-42.
RX PubMed=4024452; DOI=10.1016/0042-6822(85)90154-0;
RA Kurilla M.G., Stone H.O., Keene J.D.;
RT "RNA sequence and transcriptional properties of the 3' end of the Newcastle
RT disease virus genome.";
RL Virology 145:203-212(1985).
RN [6]
RP INTERACTION WITH P PROTEIN.
RX PubMed=15098113; DOI=10.1007/s00705-003-0273-8;
RA Kho C.L., Tan W.S., Tey B.T., Yusoff K.;
RT "Regions on nucleocapsid protein of Newcastle disease virus that interact
RT with its phosphoprotein.";
RL Arch. Virol. 149:997-1005(2004).
CC -!- FUNCTION: Encapsidates the genome, protecting it from nucleases. The
CC nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA
CC is termed the NC and serves as template for transcription and
CC replication. During replication, encapsidation by N is coupled to RNA
CC synthesis and all replicative products are resistant to nucleases (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC genomic RNA. In nucleocapsid, binds the P protein and thereby positions
CC the polymerase on the template (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host cytoplasm.
CC -!- DOMAIN: Ncore is globular and carries regions required for N self-
CC assembly and RNA-binding. Ntail is an intrinsically disordered
CC monomeric domain (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the paramyxoviruses nucleocapsid family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF064091; AAC72076.1; -; Genomic_RNA.
DR EMBL; AF144730; AAF14883.1; -; mRNA.
DR EMBL; AF419409; AAL09062.1; -; Genomic_RNA.
DR EMBL; DQ060053; AAY68569.1; -; Genomic_RNA.
DR EMBL; M11204; AAA46676.1; -; Genomic_RNA.
DR SMR; P09459; -.
DR GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0039697; P:negative stranded viral RNA transcription; IDA:UniProtKB.
DR InterPro; IPR002021; Paramyx_ncap.
DR Pfam; PF00973; Paramyxo_ncap; 1.
PE 1: Evidence at protein level;
KW Capsid protein; Helical capsid protein; Host cytoplasm; Ribonucleoprotein;
KW RNA-binding; Viral nucleoprotein; Virion.
FT CHAIN 1..489
FT /note="Nucleoprotein"
FT /id="PRO_0000142664"
FT REGION 1..400
FT /note="Ncore"
FT /evidence="ECO:0000250"
FT REGION 1..375
FT /note="P protein-binding"
FT /evidence="ECO:0000250"
FT REGION 401..489
FT /note="Ntail"
FT /evidence="ECO:0000250"
FT REGION 421..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..441
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 489 AA; 53110 MW; D737A561C97F3A64 CRC64;
MSSVFDEYEQ LLAAQTRPNG AHGGGEKGST LKVDVPVFTL NSDDPEDRWN FAVFCLRIAV
SEDANKPLRQ GALISLLCSH SQVMRNHVAL AGKQNEATLA VLEIDGFANG MPQFNNRSGV
SEERAQRFAM IAGSLPRACS NGTPFVTAGA EDDAPEDITD TLERILSIQA QVWVTVAKAM
TAYETADESE TRRINKYMQQ GRVQKKYILY PVCRSTIQLT IRQSLAVRIF LVSELKRGRN
TAGGTSTYYN LVGDVDSYIR NTGLTAFFLT LKYGINTKTS ALALSSLSGD IQKMKQLMRL
YRMKGDNAPY MTLLGDSDQM SFAPAEYAQL YSFAMGMASV LDKGTGKYQF ARDFMSTSFW
RLGVEYAQAQ GSSINEDMAA ELKLTPAARR GLAAAAQRVS EETSSIDMPT QQVGVLTGLS
EGGSQALQGG SNRSQGQPEA GDGETQFLDL MRAVANSMRE APNSAQGTPQ SGPPPTPGPS
QDNDTDWGY
