ID   NCAP_NDVB1              Reviewed;         489 AA.
AC   Q77K03;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   02-JUN-2021, entry version 47.
DE   RecName: Full=Nucleoprotein;
DE   AltName: Full=Nucleocapsid protein;
DE            Short=NP;
DE            Short=Protein N;
GN   Name=N; Synonyms=NP;
OS   Newcastle disease virus (strain Chicken/United States/B1/48) (NDV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Avulavirinae;
OC   Orthoavulavirus; Avian orthoavulavirus 1.
OX   NCBI_TaxID=652953;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=B1;
RA   Sellers H.S., Seal B.S.;
RT   "Complete sequence for the B1 strain of Newcastle disease virus.";
RL   Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Encapsidates the genome, protecting it from nucleases. The
CC       nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA
CC       is termed the NC and serves as template for transcription and
CC       replication. During replication, encapsidation by N is coupled to RNA
CC       synthesis and all replicative products are resistant to nucleases (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC       genomic RNA. In nucleocapsid, binds the P protein and thereby positions
CC       the polymerase on the template (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host cytoplasm.
CC   -!- DOMAIN: Ncore is globular and carries regions required for N self-
CC       assembly and RNA-binding. Ntail is an intrinsically disordered
CC       monomeric domain (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the paramyxoviruses nucleocapsid family.
CC       {ECO:0000305}.
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DR   EMBL; AF309418; AAG36982.1; -; Genomic_RNA.
DR   RefSeq; NP_071466.1; NC_002617.1.
DR   SMR; Q77K03; -.
DR   Proteomes; UP000002328; Genome.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR002021; Paramyx_ncap.
DR   Pfam; PF00973; Paramyxo_ncap; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Helical capsid protein; Host cytoplasm; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Viral nucleoprotein; Virion.
FT   CHAIN           1..489
FT                   /note="Nucleoprotein"
FT                   /id="PRO_0000390786"
FT   REGION          1..400
FT                   /note="Ncore"
FT                   /evidence="ECO:0000250"
FT   REGION          1..375
FT                   /note="P protein-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          401..489
FT                   /note="Ntail"
FT                   /evidence="ECO:0000250"
FT   REGION          421..489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        421..441
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   489 AA;  53023 MW;  4DCA1B1E8A942319 CRC64;
     MSSVFDEYEQ LLAAQTRPNG AHGGGEKGST LKVDVPVFTL NSDDPEDRWS FVVFCLRIAV
     SEDANKPLRQ GALISLLCSH SQVMRNHVAL AGKQNEATLA VLEIDGFANG TPQFNNRSGV
     SEERAQRFAM IAGSLPRACS NGTPFVTAGA EDDAPEDITD TLERILSIQA QVWVTVAKAM
     TAYETADESE TRRINKYMQQ GRVQKKYILY PVCRSTIQLT IRQSLAVRIF LVSELKRGRN
     TAGGTSTYYN LVGDVDSYIR NTGLTAFFLT LKYGINTKTS ALALSSLSGD IQKMKQLMRL
     YRMKGDNAPY MTLLGDSDQM SFAPAEYAQL YSFAMGMASV LDKGTGKYQF AKDFMSTSFW
     RLGVEYAQAQ GSSINEDMAA ELKLTPAARR GLAAAAQRVS EVTSSIDMPT QQVGVLTGLS
     EGGSQALQGG SNRSQGQPEA GDGETQFLDL MRAVANSMRE APNSAQGTPQ SGPPPTPGPS
     QDNDTDWGY