NCAP_NIPAV
ID NCAP_NIPAV Reviewed; 532 AA.
AC Q9IK92; Q4KTA9; Q5K4E2; Q8QU03;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Nucleoprotein;
DE Short=Protein N;
DE AltName: Full=Nucleocapsid protein;
GN Name=N;
OS Nipah virus.
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC Henipavirus.
OX NCBI_TaxID=121791;
OH NCBI_TaxID=58060; Cynopterus brachyotis (Lesser short-nosed fruit bat) (Pachysoma brachyotis).
OH NCBI_TaxID=58065; Eonycteris spelaea (Lesser dawn bat) (Macroglossus spelaeus).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9405; Pteropus hypomelanus (Island flying fox) (Variable flying fox).
OH NCBI_TaxID=132908; Pteropus vampyrus (Large flying fox).
OH NCBI_TaxID=153297; Scotophilus kuhlii (Lesser asiatic yellow bat).
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=10827955; DOI=10.1126/science.288.5470.1432;
RA Chua K.B., Bellini W.J., Rota P.A., Harcourt B.H., Tamin A., Lam S.K.,
RA Ksiazek T.G., Rollin P.E., Zaki S.R., Shieh W., Goldsmith C.S.,
RA Gubler D.J., Roehrig J.T., Eaton B., Gould A.R., Olson J., Field H.,
RA Daniels P., Ling A.E., Peters C.J., Anderson L.J., Mahy B.W.;
RT "Nipah virus: a recently emergent deadly paramyxovirus.";
RL Science 288:1432-1435(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate UMMC1, and Isolate UMMC2;
RX PubMed=11514724; DOI=10.1099/0022-1317-82-9-2151;
RA Chan Y.P., Chua K.B., Koh C.L., Lim M.E., Lam S.K.;
RT "Complete nucleotide sequences of Nipah virus isolates from Malaysia.";
RL J. Gen. Virol. 82:2151-2155(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate Malaysian flying-fox;
RX PubMed=11880045; DOI=10.1016/s1286-4579(01)01522-2;
RA Chua K.B., Koh C.L., Hooi P.S., Wee K.F., Khong J.H., Chua B.H., Chan Y.P.,
RA Lim M.E., Lam S.K.;
RT "Isolation of Nipah virus from Malaysian island flying-foxes.";
RL Microbes Infect. 4:145-151(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate NiV/MY/99/UM-0128, Isolate NiV/MY/99/VRI-1413, and
RC Isolate NiV/MY/99/VRI-2794;
RX PubMed=15663869; DOI=10.3201/eid1012.040452;
RA Abubakar S., Chang L.Y., Mohdali A.R., Sharifah S.H., Yusoff K., Zamrod Z.;
RT "Isolation and molecular identification of Nipah virus from pigs.";
RL Emerg. Infect. Dis. 10:2228-2230(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate NiV/KHM/CSUR381;
RX PubMed=16022778; DOI=10.3201/eid1107.041350;
RA Reynes J.-M., Counor D., Ong S., Faure C., Seng V., Molia S., Walston J.,
RA Georges-Courbot M., Deubel V., Sarthou J.-L.;
RT "Nipah virus in Lyle's flying foxes, Cambodia.";
RL Emerg. Infect. Dis. 11:1042-1047(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Isolate NiV/MY/99/VRI-0626;
RA Abubakar S., Li-Yen C., Mohd Ali A.R., Sharifah S.H.;
RT "Identification of a new Nipah virus strain from pigs.";
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Encapsidates the genome protecting it from nucleases. The
CC encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as
CC template for transcription and replication (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC genomic RNA. N in nucleocapsid binds the P protein and thereby
CC positions the polymerase on the template (By similarity).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q9IK92; Q9IK91: P/V/C; NbExp=5; IntAct=EBI-16116412, EBI-16116432;
CC -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the paramyxoviruses nucleocapsid family.
CC {ECO:0000305}.
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DR EMBL; AF212302; AAF73377.1; -; Genomic_RNA.
DR EMBL; AY029767; AAK50540.1; -; Genomic_RNA.
DR EMBL; AJ564621; CAD92347.1; -; Genomic_RNA.
DR EMBL; AY029768; AAK50548.1; -; Genomic_RNA.
DR EMBL; AJ564622; CAD92353.1; -; Genomic_RNA.
DR EMBL; AJ564623; CAD92359.1; -; Genomic_RNA.
DR EMBL; AF376747; AAM13401.1; -; Genomic_RNA.
DR EMBL; AY858110; AAX51852.1; -; Genomic_RNA.
DR EMBL; AJ627196; CAF25493.1; -; Genomic_RNA.
DR RefSeq; NP_112021.1; NC_002728.1.
DR PDB; 4CO6; X-ray; 2.50 A; A/B/C=32-383.
DR PDB; 7NT5; EM; 3.50 A; A/B/C/D/E/F/G/H/I/J/K/L/M=1-532.
DR PDB; 7NT6; EM; 4.30 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N/O=1-532.
DR PDBsum; 4CO6; -.
DR PDBsum; 7NT5; -.
DR PDBsum; 7NT6; -.
DR SMR; Q9IK92; -.
DR DIP; DIP-61041N; -.
DR IntAct; Q9IK92; 16.
DR MINT; Q9IK92; -.
DR GeneID; 920951; -.
DR KEGG; vg:920951; -.
DR Proteomes; UP000002330; Genome.
DR Proteomes; UP000007527; Genome.
DR Proteomes; UP000008676; Genome.
DR Proteomes; UP000100567; Genome.
DR Proteomes; UP000110983; Genome.
DR Proteomes; UP000130871; Genome.
DR Proteomes; UP000170143; Genome.
DR GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0039689; P:negative stranded viral RNA replication; IDA:UniProtKB.
DR GO; GO:0039697; P:negative stranded viral RNA transcription; IDA:UniProtKB.
DR DisProt; DP00697; -.
DR InterPro; IPR002021; Paramyx_ncap.
DR Pfam; PF00973; Paramyxo_ncap; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Capsid protein; Helical capsid protein; Host cytoplasm;
KW Reference proteome; Ribonucleoprotein; RNA-binding; Viral nucleoprotein;
KW Virion.
FT CHAIN 1..532
FT /note="Nucleoprotein"
FT /id="PRO_0000235999"
FT REGION 422..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 30
FT /note="T -> I (in strain: Isolate Malaysian flying-fox)"
FT VARIANT 139
FT /note="S -> R (in strain: Isolate NiV/MY/99/VRI-0626)"
FT VARIANT 345
FT /note="M -> I (in strain: Isolate NiV/MY/99/VRI-0626)"
FT VARIANT 429
FT /note="I -> V (in strain: Isolate NiV/KHM/CSUR381)"
FT VARIANT 432
FT /note="G -> E (in strain: Isolate NiV/KHM/CSUR381)"
FT VARIANT 457
FT /note="N -> D (in strain: Isolate NiV/KHM/CSUR381)"
FT VARIANT 502
FT /note="I -> T (in strain: Isolate NiV/KHM/CSUR381)"
FT VARIANT 511
FT /note="E -> G (in strain: Isolate NiV/KHM/CSUR381)"
FT VARIANT 518
FT /note="L -> P (in strain: Isolate NiV/KHM/CSUR381)"
FT VARIANT 521
FT /note="A -> T (in strain: Isolate NiV/KHM/CSUR381)"
FT HELIX 5..17
FT /evidence="ECO:0007829|PDB:7NT5"
FT STRAND 18..20
FT /evidence="ECO:0007829|PDB:7NT5"
FT HELIX 26..28
FT /evidence="ECO:0007829|PDB:7NT5"
FT STRAND 34..42
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 45..59
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 66..78
FT /evidence="ECO:0007829|PDB:4CO6"
FT STRAND 81..83
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 84..91
FT /evidence="ECO:0007829|PDB:4CO6"
FT STRAND 98..104
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 105..107
FT /evidence="ECO:0007829|PDB:7NT5"
FT STRAND 109..112
FT /evidence="ECO:0007829|PDB:7NT5"
FT HELIX 123..138
FT /evidence="ECO:0007829|PDB:4CO6"
FT STRAND 139..141
FT /evidence="ECO:0007829|PDB:4CO6"
FT STRAND 144..147
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 149..152
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 158..180
FT /evidence="ECO:0007829|PDB:4CO6"
FT STRAND 183..185
FT /evidence="ECO:0007829|PDB:7NT5"
FT HELIX 192..199
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 205..207
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 211..223
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 225..240
FT /evidence="ECO:0007829|PDB:4CO6"
FT STRAND 241..243
FT /evidence="ECO:0007829|PDB:7NT5"
FT HELIX 246..263
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 265..274
FT /evidence="ECO:0007829|PDB:4CO6"
FT TURN 275..277
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 280..283
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 285..287
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 288..304
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 305..313
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 316..318
FT /evidence="ECO:0007829|PDB:4CO6"
FT TURN 319..322
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 324..326
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 328..341
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 346..349
FT /evidence="ECO:0007829|PDB:4CO6"
FT HELIX 357..369
FT /evidence="ECO:0007829|PDB:4CO6"
FT TURN 372..374
FT /evidence="ECO:0007829|PDB:7NT5"
FT TURN 380..382
FT /evidence="ECO:0007829|PDB:7NT5"
FT HELIX 386..395
FT /evidence="ECO:0007829|PDB:7NT5"
SQ SEQUENCE 532 AA; 58168 MW; 8146C5BE9EA994EA CRC64;
MSDIFEEAAS FRSYQSKLGR DGRASAATAT LTTKIRIFVP ATNSPELRWE LTLFALDVIR
SPSAAESMKV GAAFTLISMY SERPGALIRS LLNDPDIEAV IIDVGSMVNG IPVMERRGDK
AQEEMEGLMR ILKTARDSSK GKTPFVDSRA YGLRITDMST LVSAVITIEA QIWILIAKAV
TAPDTAEESE TRRWAKYVQQ KRVNPFFALT QQWLTEMRNL LSQSLSVRKF MVEILIEVKK
GGSAKGRAVE IISDIGNYVE ETGMAGFFAT IRFGLETRYP ALALNEFQSD LNTIKSLMLL
YREIGPRAPY MVLLEESIQT KFAPGGYPLL WSFAMGVATT IDRSMGALNI NRGYLEPMYF
RLGQKSARHH AGGIDQNMAN RLGLSSDQVA ELAAAVQETS AGRQESNVQA REAKFAAGGV
LIGGSDQDID EGEEPIEQSG RQSVTFKREM SISSLANSVP SSSVSTSGGT RLTNSLLNLR
SRLAAKAAKE AASSNATDDP AISNRTQGES EKKNNQDLKP AQNDLDFVRA DV
