NCAP_PI1HA
ID NCAP_PI1HA Reviewed; 524 AA.
AC P36354;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 23-FEB-2022, entry version 67.
DE RecName: Full=Nucleoprotein;
DE AltName: Full=Nucleocapsid protein;
DE Short=NP;
DE Short=Protein N;
GN Name=N; Synonyms=NP;
OS Human parainfluenza 1 virus (strains A1426 / 86-315 / 62m-753) (HPIV-1).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC Respirovirus.
OX NCBI_TaxID=36412;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=1605738; DOI=10.1007/bf01309807;
RA Miyahara K., Kitada S., Yoshimoto M., Matsumura H., Kawano M., Komada H.,
RA Tsurudome M., Kusagawa S., Nishio M., Ito Y.;
RT "Molecular evolution of human paramyxoviruses. Nucleotide sequence analyses
RT of the human parainfluenza type 1 virus NP and M protein genes and
RT construction of phylogenetic trees for all the human paramyxoviruses.";
RL Arch. Virol. 124:255-268(1992).
CC -!- FUNCTION: Encapsidates the genome in a ratio of 1 N per 6
CC ribonucleotides, protecting it from nucleases. The nucleocapsid (NC)
CC has a helical structure. The encapsidated genomic RNA is termed the NC
CC and serves as template for transcription and replication. During
CC replication, encapsidation by N is coupled to RNA synthesis and all
CC replicative products are resistant to nucleases (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC genomic RNA. In nucleocapsid, binds the P protein and thereby positions
CC the polymerase on the template.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host cytoplasm.
CC -!- DOMAIN: Ncore is globular and carries regions required for N self-
CC assembly and RNA-binding. Ntail is an intrinsically disordered
CC monomeric domain (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the paramyxoviruses nucleocapsid family.
CC {ECO:0000305}.
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DR EMBL; S38060; AAB22343.1; -; Genomic_RNA.
DR PIR; A48341; A48341.
DR SMR; P36354; -.
DR GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR002021; Paramyx_ncap.
DR Pfam; PF00973; Paramyxo_ncap; 1.
PE 3: Inferred from homology;
KW Capsid protein; Helical capsid protein; Host cytoplasm; Ribonucleoprotein;
KW RNA-binding; Viral nucleoprotein; Virion.
FT CHAIN 1..524
FT /note="Nucleoprotein"
FT /id="PRO_0000142671"
FT REGION 1..400
FT /note="Ncore"
FT /evidence="ECO:0000250"
FT REGION 401..524
FT /note="Ntail"
FT /evidence="ECO:0000250"
FT REGION 496..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 57737 MW; 6499DCC8912F708B CRC64;
MAGLLSTFDT FSSRRSESIN KSGGGAIIPG QRSTVSVFTL GPSVTDDADK LLIATTFLAH
SLDTDKQHSQ RGGFLVSLLA MAYSSPELYL TTNGVNADVK YVIYNIERDP KRTKTDGFIV
KTRDMEYERT TEWLFGPMIN KNPLFQGQRE NADLEALLQT YGYPACLGAI IVQVWIVLVK
AITSSAGLRK GFFNRLEAFR QDGTVKSALV FTGDTVEGIG AVMRSQQSLV SLMVETLVTM
NTSRSDLTTL EKNIQIVGNY IRDAGLASFM NTIKYGVETK MAALTLSNLR PDLNKLRSLV
DIYLSKGARA PFICILRDPV HGDFAPGNYP ALWSYAMGVA VVQNKAMQQY VTGRTYLDME
MFLLGQAVAK DADSKISSAL EEELGVTDTA KERLRHHLTN LSGGDGAYHK PTGGGAIEVA
IDHTDITFGV EDTADRDNKN WTNDSNERWM NHSTNNHTIT IHGAEELEEE TNDEDIIDIE
NKIARRLADR KQRLNQANNK RDISSDADYE NDDDATAAAE IGGI
