NCAP_SBVBH
ID NCAP_SBVBH Reviewed; 233 AA.
AC H2AM13;
DT 29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 1.
DT 29-SEP-2021, entry version 33.
DE RecName: Full=Nucleoprotein;
DE AltName: Full=Nucleocapsid protein;
DE Short=Protein N;
GN Name=N;
OS Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC Ellioviricetes; Bunyavirales; Peribunyaviridae; Orthobunyavirus;
OC Schmallenberg orthobunyavirus.
OX NCBI_TaxID=1318464;
OH NCBI_TaxID=9913; Bos taurus (Bovine).
OH NCBI_TaxID=9940; Ovis aries (Sheep).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=22376991; DOI=10.3201/eid1803.111905;
RA Hoffmann B., Scheuch M., Hoper D., Jungblut R., Holsteg M., Schirrmeier H.,
RA Eschbaumer M., Goller K.V., Wernike K., Fischer M., Breithaupt A.,
RA Mettenleiter T.C., Beer M.;
RT "Novel orthobunyavirus in cattle, europe, 2011.";
RL Emerg. Infect. Dis. 18:469-472(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA Hoeper D.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=BH02/12-1, BH148/12-9, BH200/12-2, BH248/12-1, BH336/12-1,
RC BH336/12-3, BH37/12-2, BH619/12-1, BH635/12-2, BH652/12-1, and BH77/12-1;
RA Fischer M., Hoffmann B., Goller K.V., Wernike K., Beer M.;
RT "Hot spot of mutation in the Schmallenberg virus M-segment detected in
RT German field isolates.";
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Germany;
RX PubMed=23326235; DOI=10.1371/journal.ppat.1003133;
RA Varela M., Schnettler E., Caporale M., Murgia C., Barry G., McFarlane M.,
RA McGregor E., Piras I.M., Shaw A., Lamm C., Janowicz A., Beer M., Glass M.,
RA Herder V., Hahn K., Baumgartner W., Kohl A., Palmarini M.;
RT "Schmallenberg virus pathogenesis, tropism and interaction with the innate
RT immune system of the host.";
RL PLoS Pathog. 9:E1003133-E1003133(2013).
CC -!- FUNCTION: Encapsidates the genome, protecting it from nucleases. The
CC encapsidated genomic RNA is termed the nucleocapsid (NC) (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: omomultimerizes to form the nucleocapsid. Binds to viral
CC genomic RNA (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion. Note=Internal protein of virus particle.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative initiation; Named isoforms=2;
CC Name=N;
CC IsoId=H2AM13-1; Sequence=Displayed;
CC Name=NSS;
CC IsoId=H2AM14-1; Sequence=External;
CC -!- SIMILARITY: Belongs to the orthobunyavirus nucleocapsid protein family.
CC {ECO:0000305}.
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DR EMBL; JX853181; AGC84162.1; -; Viral_cRNA.
DR EMBL; KC108842; AGC93537.1; -; Viral_cRNA.
DR EMBL; KC108848; AGC93540.1; -; Viral_cRNA.
DR EMBL; KC108852; AGC93542.1; -; Viral_cRNA.
DR EMBL; KC108856; AGC93544.1; -; Viral_cRNA.
DR EMBL; KC108866; AGC93549.1; -; Viral_cRNA.
DR EMBL; KC108874; AGC93553.1; -; Viral_cRNA.
DR EMBL; KC108878; AGC93555.1; -; Viral_cRNA.
DR EMBL; KC108880; AGC93556.1; -; Viral_cRNA.
DR EMBL; KC108882; AGC93557.1; -; Viral_cRNA.
DR EMBL; KC108884; AGC93558.1; -; Viral_cRNA.
DR EMBL; KC108886; AGC93559.1; -; Viral_cRNA.
DR EMBL; HE649914; CCF55031.1; -; Genomic_RNA.
DR PDB; 3ZL9; X-ray; 2.75 A; A/B/C/D=1-233.
DR PDB; 4IDU; X-ray; 3.08 A; A/B/C/D=1-233.
DR PDB; 4IDX; X-ray; 3.21 A; A/B/C=1-233.
DR PDB; 4JNG; X-ray; 2.12 A; A/B/C/D=1-233.
DR PDBsum; 3ZL9; -.
DR PDBsum; 4IDU; -.
DR PDBsum; 4IDX; -.
DR PDBsum; 4JNG; -.
DR SMR; H2AM13; -.
DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.472.180; -; 1.
DR Gene3D; 1.20.142.20; -; 1.
DR InterPro; IPR001784; Bunya_nucleocap.
DR InterPro; IPR043011; Bunya_nucleocap_C.
DR InterPro; IPR043012; Bunya_nucleocap_N.
DR Pfam; PF00952; Bunya_nucleocap; 1.
DR PIRSF; PIRSF003947; N_OrthobunV; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative initiation; Ribonucleoprotein; RNA-binding;
KW Viral nucleoprotein; Virion.
FT CHAIN 1..233
FT /note="Nucleoprotein"
FT /id="PRO_0000422475"
FT HELIX 20..31
FT /evidence="ECO:0007829|PDB:4JNG"
FT HELIX 32..34
FT /evidence="ECO:0007829|PDB:4JNG"
FT HELIX 37..45
FT /evidence="ECO:0007829|PDB:4JNG"
FT HELIX 47..56
FT /evidence="ECO:0007829|PDB:4JNG"
FT STRAND 59..66
FT /evidence="ECO:0007829|PDB:4JNG"
FT STRAND 69..74
FT /evidence="ECO:0007829|PDB:4JNG"
FT HELIX 79..81
FT /evidence="ECO:0007829|PDB:4JNG"
FT HELIX 93..110
FT /evidence="ECO:0007829|PDB:4JNG"
FT HELIX 112..121
FT /evidence="ECO:0007829|PDB:4JNG"
FT TURN 125..127
FT /evidence="ECO:0007829|PDB:4JNG"
FT HELIX 128..130
FT /evidence="ECO:0007829|PDB:4JNG"
FT HELIX 134..136
FT /evidence="ECO:0007829|PDB:4JNG"
FT HELIX 138..142
FT /evidence="ECO:0007829|PDB:4JNG"
FT HELIX 148..151
FT /evidence="ECO:0007829|PDB:4JNG"
FT TURN 152..157
FT /evidence="ECO:0007829|PDB:4JNG"
FT HELIX 158..168
FT /evidence="ECO:0007829|PDB:4JNG"
FT HELIX 177..181
FT /evidence="ECO:0007829|PDB:4JNG"
FT STRAND 185..187
FT /evidence="ECO:0007829|PDB:4IDU"
FT HELIX 190..196
FT /evidence="ECO:0007829|PDB:4JNG"
FT HELIX 198..209
FT /evidence="ECO:0007829|PDB:4JNG"
FT HELIX 222..225
FT /evidence="ECO:0007829|PDB:4JNG"
FT TURN 226..228
FT /evidence="ECO:0007829|PDB:4JNG"
SQ SEQUENCE 233 AA; 26181 MW; 78093278B94464E9 CRC64;
MSSQFIFEDV PQRNAATFNP EVGYVAFIGK YGQQLNFGVA RVFFLNQKKA KMVLHKTAQP
SVDLTFGGVK FTVVNNHFPQ YVSNPVPDNA ITLHRMSGYL ARWIADTCKA SVLKLAEASA
QIVMPLAEVK GCTWADGYTM YLGFAPGAEM FLDAFDFYPL VIEMHRVLKD NMDVNFMKKV
LRQRYGTMTA EEWMTQKITE IKAAFNSVGQ LAWAKSGFSP AARTFLQQFG INI
