ID   NCAP_SENDA              Reviewed;         524 AA.
AC   Q9DUE3;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   23-FEB-2022, entry version 69.
DE   RecName: Full=Nucleoprotein;
DE   AltName: Full=Nucleocapsid protein;
DE            Short=NP;
DE            Short=Protein N;
GN   Name=N; Synonyms=NP;
OS   Sendai virus (strain Hamamatsu) (SeV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC   Respirovirus.
OX   NCBI_TaxID=302271;
OH   NCBI_TaxID=10144; Cavia cutleri (Guinea pig).
OH   NCBI_TaxID=36483; Cricetidae sp. (Hamster).
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
OH   NCBI_TaxID=10116; Rattus norvegicus (Rat).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=11210938; DOI=10.1023/a:1008130318633;
RA   Fujii Y., Kiyotani K., Yoshida T., Sakaguchi T.;
RT   "Conserved and non-conserved regions in the Sendai virus genome: evolution
RT   of a gene possessing overlapping reading frames.";
RL   Virus Genes 22:47-52(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=12163573; DOI=10.1128/jvi.76.17.8540-8547.2002;
RA   Fujii Y., Sakaguchi T., Kiyotani K., Huang C., Fukuhara N., Egi Y.,
RA   Yoshida T.;
RT   "Involvement of the leader sequence in Sendai virus pathogenesis revealed
RT   by recovery of a pathogenic field isolate from cDNA.";
RL   J. Virol. 76:8540-8547(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate E15cl2, Isolate E30cl2, and Isolate E30M15cl5;
RX   PubMed=12416681; DOI=10.1023/a:1020165919672;
RA   Fujii Y., Sakaguchi T., Kiyotani K., Huang C., Fukuhara N., Yoshida T.;
RT   "Identification of mutations associated with attenuation of virulence of a
RT   field Sendai virus isolate by egg passage.";
RL   Virus Genes 25:189-193(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate E50cl9;
RA   Fujii Y., Kiyotani K., Huang C., Fukuhara N., Egi K., Yoshida T.,
RA   Sakaguchi T.;
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Encapsidates the genome in a ratio of one N per six
CC       ribonucleotides, protecting it from nucleases. The nucleocapsid (NC)
CC       has a helical structure with 13.07 N per turn. The encapsidated genomic
CC       RNA is termed the NC and serves as template for transcription and
CC       replication. Replication is dependent on intracellular concentration of
CC       newly synthesized N, termed N(0), which corresponds to the protein not
CC       associated with RNA. In contrast, when associated with RNA, it is
CC       termed N. During replication, encapsidation by N(0) is coupled to RNA
CC       synthesis and all replicative products are resistant to nucleases (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC       genomic RNA. N in nucleocapsid binds the P protein and thereby
CC       positions the polymerase on the template. Interaction of N(0) with the
CC       P protein prevents the uncontrolled aggregation of N(0) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host cytoplasm.
CC   -!- DOMAIN: There are two distinct binding regions to the P protein, one
CC       used by N(0) and the other by N in nucleocapsid. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Most abundant protein in the virion. There are 2564
CC       molecules per encapsidated genome (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the paramyxoviruses nucleocapsid family.
CC       {ECO:0000305}.
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DR   EMBL; AB039658; BAB20019.1; -; Genomic_RNA.
DR   EMBL; AB065186; BAC79125.1; -; Genomic_RNA.
DR   EMBL; AB065187; BAC07505.1; -; Genomic_RNA.
DR   EMBL; AB065188; BAC79133.1; -; Genomic_RNA.
DR   EMBL; AB065189; BAC79141.1; -; Genomic_RNA.
DR   SMR; Q9DUE3; -.
DR   Proteomes; UP000007191; Genome.
DR   Proteomes; UP000008510; Genome.
DR   Proteomes; UP000008857; Genome.
DR   Proteomes; UP000180650; Genome.
DR   Proteomes; UP000180718; Genome.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR002021; Paramyx_ncap.
DR   Pfam; PF00973; Paramyxo_ncap; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Helical capsid protein; Host cytoplasm; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Viral nucleoprotein; Virion.
FT   CHAIN           1..524
FT                   /note="Nucleoprotein"
FT                   /id="PRO_0000142679"
FT   REGION          462..471
FT                   /note="Binding of N in nucleoprotein to P protein"
FT                   /evidence="ECO:0000250"
FT   REGION          487..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        487..516
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   524 AA;  57195 MW;  C4890EEC57F4CC45 CRC64;
     MAGLLSTFDT FSSRRSESIN KSGGGAVIPG QRSTVSVFVL GPSVTDDADK LFIATTFLAH
     SLDTDKQHSQ RGGFLVSLLA MAYSSPELYL TTNGVNADVK YVIYNIEKDP KRTKTDGFIV
     KTRDMEYERT TEWLFGPMVN KSPLFQGQRD AADPDTLLQI YGYPACLGAI IVQVWIVLVK
     AITSSAGLRK GFFNRLEAFR QDGTVKGALV FTGETVEGIG SVMRSQQSLV SLMVETLVTM
     NTARSDLTTL EKNIQIVGNY IRDAGLASFM NTIKYGVETK MAALTLSNLR PDINKLRSLI
     DTYLSKGPRA PFICILKDPV HGEFAPGNYP ALWSYAMGVA VVQNKAMQQY VTGRTYLDME
     MFLLGQAVAK DAESKISSAL EDELGVTDTA KERLRHHLAN LSGGDGAYHK PTGGGAIEVA
     LDNADIDLEP EAHTDQDARG WGGDSGDRWA RSTSSGHFIT LHGAERLEEE TNDEDVSDIE
     RRIARRLAER RQEDATTHED EGRNNGVDHD EEDDAAAAAG MGGI