ID   NCAP_SHRV               Reviewed;         399 AA.
AC   Q9QJT9;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   23-FEB-2022, entry version 61.
DE   RecName: Full=Nucleoprotein;
DE            Short=NP;
DE   AltName: Full=Nucleocapsid protein;
DE            Short=Protein N;
GN   Name=N;
OS   Snakehead rhabdovirus (SHRV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Gammarhabdovirinae;
OC   Novirhabdovirus.
OX   NCBI_TaxID=103603;
OH   NCBI_TaxID=203314; Gobiosoma bosc (Naked goby) (Gobius bosc).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=10666265; DOI=10.1128/jvi.74.5.2343-2350.2000;
RA   Johnson M.C., Simon B.E., Kim C.H., Leong J.A.;
RT   "Production of recombinant snakehead rhabdovirus: the NV protein is not
RT   required for viral replication.";
RL   J. Virol. 74:2343-2350(2000).
CC   -!- FUNCTION: Encapsidates the genome, protecting it from nucleases. If
CC       expressed without protein P it binds non-specifically RNA and therefore
CC       can bind it's own mRNA. Interaction with protein P abolishes any non-
CC       specific RNA binding, and prevents phosphorylation. The soluble N-P
CC       complex encapsidates specifically the genomic RNA, with protein N
CC       protecting the genome like a pearl necklace. The encapsidated genomic
CC       RNA is termed the nucleocapsid (NC) and serves as template for viral
CC       transcription and replication. Protein N binds protein P in the NC
CC       through a different interaction, and can be phosphorylated. Subsequent
CC       viral replication is dependent on intracellular concentration of newly
CC       synthesized protein N. During replication, encapsidation by protein N
CC       is coupled to RNA synthesis and all replicative products are resistant
CC       to nucleases (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC       genomic RNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the novirhabdovirus nucleocapsid protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF147498; AAD56766.1; -; Genomic_RNA.
DR   RefSeq; NP_050580.1; NC_000903.1.
DR   SMR; Q9QJT9; -.
DR   GeneID; 1457769; -.
DR   KEGG; vg:1457769; -.
DR   Proteomes; UP000007219; Genome.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004902; Rhabdo_ncap_2.
DR   Pfam; PF03216; Rhabdo_ncap_2; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Helical capsid protein; Host cytoplasm; Phosphoprotein;
KW   Reference proteome; Ribonucleoprotein; RNA-binding; Viral nucleoprotein;
KW   Virion.
FT   CHAIN           1..399
FT                   /note="Nucleoprotein"
FT                   /id="PRO_0000297614"
FT   REGION          361..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   399 AA;  43368 MW;  03AD4BC43B7B30DF CRC64;
     MAFQKEFFGL RDVKVDLSAG EGLDFDPSEV ELTVYRTGAD TDGNTIIKAL AAVGGPKTNE
     ALSVLLAFVT LGTDQDEYET RIKILKEIGF SVKEVPMAKD ASSGIEAPLE NVAALVKPET
     VYQVIRGVLY TCALFVKYNV EKMQKYIKNK LPALATSYGV PELEEFPTES SALKKLASCI
     RPGQRITNAL YAFLLVEMAR PETQQGARAL AAMRINGTGM TMVGLFTQAA KNLGATPSDL
     LEDLCMRSLV DSARRIVRLM VQVSQAETIQ ARYAVMMSRM LNENYFKAYG LNDNSRISAI
     LVAVNGHFSE DTIEALEGIK VSAEFADLAR RIAIALIEKY DNASDGGEGA SEIIKSAVRG
     SSGAFKGSRG KPQGRRQEAS GEGDLDSEDD DDQDYSKYA