ID   NCAP_TIBVC              Reviewed;         428 AA.
AC   D8V070;
DT   04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   29-SEP-2021, entry version 37.
DE   RecName: Full=Nucleoprotein;
DE            Short=NP;
DE   AltName: Full=Nucleocapsid protein;
DE            Short=Protein N;
GN   Name=N;
OS   Tibrogargan virus (strain CS132) (TIBV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC   Tibrovirus.
OX   NCBI_TaxID=1559361;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=469753; Culicoides brevitarsis.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=CS132;
RX   PubMed=21593274; DOI=10.1099/vir.0.026120-0;
RA   Gubala A., Davis S., Weir R., Melville L., Cowled C., Boyle D.;
RT   "Tibrogargan and Coastal Plains rhabdoviruses: genomic characterization,
RT   evolution of novel genes and seroprevalence in Australian livestock.";
RL   J. Gen. Virol. 92:2160-2170(2011).
CC   -!- FUNCTION: Encapsidates the genome, protecting it from nucleases. The
CC       encapsidated genomic RNA is termed the NC and serves as template for
CC       transcription and replication. Nucleocapsid assembly is concommitant
CC       with replication, therefore viral replication depends on the
CC       intracellular concentration of free N, termed N(0). All replicative
CC       products are resistant to nucleases. {ECO:0000250|UniProtKB:P03521}.
CC   -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC       genomic RNA. N in nucleocapsid binds the P protein and thereby
CC       positions the polymerase on the template. Interaction of N(0) with the
CC       P protein prevents the uncontrolled aggregation of N(0).
CC       {ECO:0000250|UniProtKB:P03521}.
CC   -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm. Note=The nucleocapsid is
CC       synthesized in the cytoplasm, and is subsequently transported via
CC       microtubules to the cell periphery. {ECO:0000250|UniProtKB:P03521}.
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DR   EMBL; GQ294472; ADG86347.1; -; Viral_cRNA.
DR   RefSeq; YP_007641368.1; NC_020804.1.
DR   SMR; D8V070; -.
DR   GeneID; 14857906; -.
DR   KEGG; vg:14857906; -.
DR   Proteomes; UP000029770; Genome.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3570.10; -; 1.
DR   Gene3D; 1.10.3610.10; -; 1.
DR   InterPro; IPR000448; Rhabdo_ncapsid.
DR   InterPro; IPR023331; Rhabdovirus_ncapsid_C.
DR   InterPro; IPR023330; Rhabdovirus_ncapsid_N.
DR   InterPro; IPR035961; Rhabdovirus_nucleoprotein-like.
DR   Pfam; PF00945; Rhabdo_ncap; 1.
DR   SUPFAM; SSF140809; SSF140809; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Helical capsid protein; Host cytoplasm; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Viral nucleoprotein; Viral RNA replication;
KW   Virion.
FT   CHAIN           1..428
FT                   /note="Nucleoprotein"
FT                   /id="PRO_0000432066"
SQ   SEQUENCE   428 AA;  48688 MW;  7969FE9EC6CEF5DD CRC64;
     MHCLVTSTSI KLTAPSDTID VQYCSDYFEK NNKQKPKINL PKLPVGLAEL RALVKGGFKA
     NDLKLQHVLA YLGHLLQDIK GELTEDWTSF GVLIGNRSHN ITPLDLLDVN YYDDKLLDGV
     KANDASQSDD AWMLFACLGI YRLARTQNLQ HRSSILMKMN AQILSLNQNA IKLVDNTMFY
     NSWISNYNYT KLIAACDMFF YKFKDHEHAV CRFGTIPSRW KDCGGLTSLS HLKNLTGMEL
     EEIVSWVFVP SIGKEICRMM KSGQELDKPD SYVPYMMDLG LSMKSPYSSS ANGGTYTWIH
     MIGSIMHSQR SLHARMVNEN ELPNIRISAM LTAYVKFNKG SLMKVFVKEE DKHLYIGEDQ
     DENEGNGSDY IDLTQHPNTD SADDWYQWLE INNFTLDDII KDSITRECKK IQNTRAGTIG
     SYIQTTLS