ID   NCAP_TPMV               Reviewed;         552 AA.
AC   Q9WS40;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   02-JUN-2021, entry version 73.
DE   RecName: Full=Nucleoprotein;
DE   AltName: Full=Nucleocapsid protein;
DE            Short=NP;
DE            Short=Protein N;
GN   Name=N; Synonyms=Np;
OS   Tupaia paramyxovirus (TPMV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC   Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC   Narmovirus; Tupaia narmovirus.
OX   NCBI_TaxID=92129;
OH   NCBI_TaxID=37347; Tupaia belangeri (Common tree shrew) (Tupaia glis belangeri).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=10366580; DOI=10.1006/viro.1999.9693;
RA   Tidona C.A., Kurz H.W., Gelderblom H.R., Darai G.;
RT   "Isolation and molecular characterization of a novel cytopathogenic
RT   paramyxovirus from tree shrews.";
RL   Virology 258:425-434(1999).
CC   -!- FUNCTION: Encapsidates the genome, protecting it from nucleases. The
CC       nucleocapsid (NC) has a helical structure. The encapsidated genomic RNA
CC       is termed the NC and serves as template for transcription and
CC       replication. During replication, encapsidation by N is coupled to RNA
CC       synthesis and all replicative products are resistant to nucleases.
CC   -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC       genomic RNA. In nucleocapsid, binds the P protein and thereby positions
CC       the polymerase on the template (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host cytoplasm
CC       {ECO:0000250}.
CC   -!- DOMAIN: Ncore is globular and carries regions required for N self-
CC       assembly and RNA-binding. Ntail is an intrinsically disordered
CC       monomeric domain (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the paramyxoviruses nucleocapsid family.
CC       {ECO:0000305}.
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DR   EMBL; AF079780; AAD28694.1; -; Genomic_RNA.
DR   RefSeq; NP_054690.1; NC_002199.1.
DR   SMR; Q9WS40; -.
DR   GeneID; 1452635; -.
DR   KEGG; vg:1452635; -.
DR   Proteomes; UP000136220; Genome.
DR   GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR002021; Paramyx_ncap.
DR   Pfam; PF00973; Paramyxo_ncap; 1.
PE   3: Inferred from homology;
KW   Capsid protein; Helical capsid protein; Host cytoplasm; Reference proteome;
KW   Ribonucleoprotein; RNA-binding; Viral nucleoprotein; Virion.
FT   CHAIN           1..552
FT                   /note="Nucleoprotein"
FT                   /id="PRO_0000142687"
FT   REGION          1..400
FT                   /note="Ncore"
FT                   /evidence="ECO:0000250"
FT   REGION          401..552
FT                   /note="Ntail"
FT                   /evidence="ECO:0000250"
FT   REGION          423..552
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        433..447
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..485
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        526..552
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   552 AA;  61516 MW;  E471D28B9F277063 CRC64;
     MADLFSKVND FQKYRTNLGR QGGLTVKLVG VRSTVVVLVP STKDHRLRWK LIRLLTLAVY
     NDSLPDSISI GALLSLLAIS FEQPAAVIRG LLSDPDLEVQ MIEVSLDDQG EIRFAARGDI
     LTRYKDAYFE KIRDFPNPDD DLAIFEDPEL GDYSDITQDE YQAMITTITI QLWILLTKAV
     TAPDTAHDSE QRRFIKYLQQ RKAYAAFKFT TIFTERVRRK IAQSLSIRKF MVSIMLEVRK
     SGSAKGRISE CIADVSAYIE EAGLSGFILT LKYGIGTRFP VLALNAFQSD LSVIRNLIDL
     YKSMGTIAPF MVLIEDATQV KFAPGNYSLL WSFAMGVGTA LDHAMNNLNI NRDYLEPSYF
     RLGQEVVRLS ESTVDRSMAQ ELGIDPTSED LIMRAVQAAG VGSRDPDAAR RTGRFQVADI
     QIDEGPVDLA TEAEDQTTKD NEQRIKVPDP RGSIGQSNAQ FQPPKPQLRG RVMPPERKPT
     DQQKNLQDQR PRPSATPRRL TKDAEDNIDQ LFAQYDSGVA APEDVTLVTS DSTSPARSSG
     TGSDMDLINQ SP