NCAP_TUPVT
ID NCAP_TUPVT Reviewed; 430 AA.
AC Q4VKV8;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 23-FEB-2022, entry version 47.
DE RecName: Full=Nucleoprotein;
DE Short=NP;
DE AltName: Full=Nucleocapsid protein;
DE Short=Protein N;
GN Name=N;
OS Tupaia virus (isolate Tupaia/Thailand/-/1986) (TUPV).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Rhabdoviridae; Alpharhabdovirinae;
OC Tupavirus.
OX NCBI_TaxID=1560034;
OH NCBI_TaxID=9394; Tupaia.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=15890917; DOI=10.1128/jvi.79.11.6781-6790.2005;
RA Springfeld C., Darai G., Cattaneo R.;
RT "Characterization of the Tupaia rhabdovirus genome reveals a long open
RT reading frame overlapping with P and a novel gene encoding a small
RT hydrophobic protein.";
RL J. Virol. 79:6781-6790(2005).
CC -!- FUNCTION: Encapsidates the genome, protecting it from nucleases. The
CC encapsidated genomic RNA is termed the NC and serves as template for
CC transcription and replication. Nucleocapsid assembly is concommitant
CC with replication, therefore viral replication depends on the
CC intracellular concentration of free N, termed N(0). All replicative
CC products are resistant to nucleases. {ECO:0000250|UniProtKB:P03521}.
CC -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC genomic RNA. N in nucleocapsid binds the P protein and thereby
CC positions the polymerase on the template. Interaction of N(0) with the
CC P protein prevents the uncontrolled aggregation of N(0).
CC {ECO:0000250|UniProtKB:P03521}.
CC -!- SUBCELLULAR LOCATION: Virion. Host cytoplasm. Note=The nucleocapsid is
CC synthesized in the cytoplasm, and is subsequently transported via
CC microtubules to the cell periphery. {ECO:0000250|UniProtKB:P03521}.
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DR EMBL; AY840978; AAX47596.1; -; Genomic_RNA.
DR RefSeq; YP_238528.1; NC_007020.1.
DR SMR; Q4VKV8; -.
DR GeneID; 3416610; -.
DR KEGG; vg:3416610; -.
DR Proteomes; UP000029771; Genome.
DR GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3570.10; -; 1.
DR Gene3D; 1.10.3610.10; -; 1.
DR InterPro; IPR000448; Rhabdo_ncapsid.
DR InterPro; IPR023331; Rhabdovirus_ncapsid_C.
DR InterPro; IPR023330; Rhabdovirus_ncapsid_N.
DR InterPro; IPR035961; Rhabdovirus_nucleoprotein-like.
DR Pfam; PF00945; Rhabdo_ncap; 1.
DR SUPFAM; SSF140809; SSF140809; 1.
PE 3: Inferred from homology;
KW Capsid protein; Helical capsid protein; Host cytoplasm; Reference proteome;
KW Ribonucleoprotein; RNA-binding; Viral nucleoprotein; Viral RNA replication;
KW Virion.
FT CHAIN 1..430
FT /note="Nucleoprotein"
FT /id="PRO_0000432065"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 430 AA; 49107 MW; 474B43AB397AA584 CRC64;
MSLSRLYSKK TQSSYNATAP LDRDPPEYPG DAFKKSRNKP TLTRPKSNLS LDDARCMIKG
QIQNGSVDIE LAKHYLILVL EQITEDNSDD WTSFGVQILS RTERGRPLCM VNIQLDDKDK
TFDSQVKDST ATVEDDLWMT TYLLAIYRIG RATNKNYQTQ LIDELNKLLA TFPGDYVPMV
QALQAFDSWP NDPNYCKLVA CVDMFFSRFK KSKWAILRFG TISSRYRDCA ALTALNHFSR
LLGVDLVDAL EWSFVGRVSD EIEQMLKPDQ ELDKVDSYTP YMIDLGISKA SPYSTVRNPA
WHLFCHTVGS LMMSRRSINA RHLEAPDQSN ILSNAELIVF VFETRIKWLK NFRKLDSVDA
SDQLDQVAPV VLGTKDLPNT TNADDWFSWM KLNNFELPDE CGRYVSKLAK KLKDSREGSV
GQFVYLRLGD
