ID   NCAS2_HUMAN             Reviewed;          99 AA.
AC   Q69YL0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Protein NCBP2AS2;
DE   AltName: Full=Hypoxia-induced angiogenesis regulator {ECO:0000303|PubMed:30723174};
DE   AltName: Full=NCBP2 antisense gene protein 2;
GN   Name=NCBP2AS2 {ECO:0000312|HGNC:HGNC:25121};
GN   Synonyms=HIAR {ECO:0000303|PubMed:30723174};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Melanoma;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712; DOI=10.1002/pmic.201400617;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA   Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND ROLE IN TUMOR ANGIOGENESIS.
RX   PubMed=30723174; DOI=10.1126/scisignal.aan8247;
RA   Kugeratski F.G., Atkinson S.J., Neilson L.J., Lilla S., Knight J.R.P.,
RA   Serneels J., Juin A., Ismail S., Bryant D.M., Markert E.K., Machesky L.M.,
RA   Mazzone M., Sansom O.J., Zanivan S.;
RT   "Hypoxic cancer-associated fibroblasts increase NCBP2-AS2/HIAR to promote
RT   endothelial sprouting through enhanced VEGF signaling.";
RL   Sci. Signal. 12:0-0(2019).
CC   -!- INTERACTION:
CC       Q69YL0; Q8NI60: COQ8A; NbExp=3; IntAct=EBI-10986258, EBI-745535;
CC       Q69YL0; Q5RI15: COX20; NbExp=3; IntAct=EBI-10986258, EBI-2834035;
CC       Q69YL0; P13473-2: LAMP2; NbExp=3; IntAct=EBI-10986258, EBI-21591415;
CC       Q69YL0; Q6NTF9-3: RHBDD2; NbExp=3; IntAct=EBI-10986258, EBI-17589229;
CC       Q69YL0; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-10986258, EBI-2623095;
CC   -!- MISCELLANEOUS: Induced by hypoxia in cancer-associated fibroblasts and
CC       promotes tumor angiogenesis by causing increased secretion of VEGFA
CC       which leads to endothelial sprouting. {ECO:0000269|PubMed:30723174}.
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DR   EMBL; AL832915; CAH10618.1; -; mRNA.
DR   EMBL; CH471191; EAW53619.1; -; Genomic_DNA.
DR   CCDS; CCDS87189.1; -.
DR   AlphaFoldDB; Q69YL0; -.
DR   SMR; Q69YL0; -.
DR   IntAct; Q69YL0; 13.
DR   BioMuta; NCBP2-AS2; -.
DR   EPD; Q69YL0; -.
DR   jPOST; Q69YL0; -.
DR   MassIVE; Q69YL0; -.
DR   MaxQB; Q69YL0; -.
DR   PeptideAtlas; Q69YL0; -.
DR   PRIDE; Q69YL0; -.
DR   Ensembl; ENST00000602845.2; ENSP00000488305.1; ENSG00000270170.2.
DR   MANE-Select; ENST00000602845.2; ENSP00000488305.1; NM_001355243.2; NP_001342172.1.
DR   GeneCards; NCBP2AS2; -.
DR   HGNC; HGNC:25121; NCBP2AS2.
DR   HPA; ENSG00000270170; Low tissue specificity.
DR   neXtProt; NX_Q69YL0; -.
DR   VEuPathDB; HostDB:ENSG00000270170; -.
DR   GeneTree; ENSGT00390000001143; -.
DR   HOGENOM; CLU_181654_0_0_1; -.
DR   OMA; YNITHMA; -.
DR   PhylomeDB; Q69YL0; -.
DR   PathwayCommons; Q69YL0; -.
DR   SignaLink; Q69YL0; -.
DR   Pharos; Q69YL0; Tdark.
DR   PRO; PR:Q69YL0; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q69YL0; protein.
DR   Bgee; ENSG00000270170; Expressed in mucosa of transverse colon and 93 other tissues.
DR   Genevisible; Q69YL0; HS.
DR   InterPro; IPR042407; NCBP2-AS2.
DR   PANTHER; PTHR41161; PTHR41161; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..99
FT                   /note="Protein NCBP2AS2"
FT                   /id="PRO_0000370383"
FT   REGION          76..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   99 AA;  10891 MW;  00C9EBD235F4EA37 CRC64;
     MVLRRLLAAL LHSPQLVERL SESRPIRRAA QLTAFALLQA QLRGQDAARR LQDLAAGPVG
     SLCRRAERFR DAFTQELRRG LRGRSGPPPG SQRGPGANI