ID   NCB2L_HUMAN             Reviewed;         153 AA.
AC   A6PVI3;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Nuclear cap-binding protein subunit 2-like;
GN   Name=NCBP2L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
CC   -!- SIMILARITY: Belongs to the RRM NCBP2 family. {ECO:0000305}.
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DR   EMBL; AL109946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS87770.1; -.
DR   RefSeq; NP_001335301.1; NM_001348372.1.
DR   AlphaFoldDB; A6PVI3; -.
DR   SMR; A6PVI3; -.
DR   STRING; 9606.ENSP00000476955; -.
DR   iPTMnet; A6PVI3; -.
DR   PhosphoSitePlus; A6PVI3; -.
DR   BioMuta; NCBP2L; -.
DR   jPOST; A6PVI3; -.
DR   MassIVE; A6PVI3; -.
DR   MaxQB; A6PVI3; -.
DR   PaxDb; A6PVI3; -.
DR   PeptideAtlas; A6PVI3; -.
DR   PRIDE; A6PVI3; -.
DR   ProteomicsDB; 1680; -.
DR   Antibodypedia; 543; 9 antibodies from 5 providers.
DR   DNASU; 392517; -.
DR   Ensembl; ENST00000509000.3; ENSP00000476955.1; ENSG00000170935.8.
DR   Ensembl; ENST00000639756.1; ENSP00000492033.1; ENSG00000170935.8.
DR   GeneID; 392517; -.
DR   KEGG; hsa:392517; -.
DR   MANE-Select; ENST00000509000.3; ENSP00000476955.1; NM_001348372.2; NP_001335301.1.
DR   UCSC; uc065apo.1; human.
DR   CTD; 392517; -.
DR   GeneCards; NCBP2L; -.
DR   HGNC; HGNC:31795; NCBP2L.
DR   HPA; ENSG00000170935; Tissue enhanced (adrenal gland, testis).
DR   neXtProt; NX_A6PVI3; -.
DR   OpenTargets; ENSG00000170935; -.
DR   VEuPathDB; HostDB:ENSG00000170935; -.
DR   eggNOG; KOG0121; Eukaryota.
DR   GeneTree; ENSGT00390000003197; -.
DR   HOGENOM; CLU_070952_2_0_1; -.
DR   InParanoid; A6PVI3; -.
DR   OMA; DWDIGFR; -.
DR   OrthoDB; 1421503at2759; -.
DR   PhylomeDB; A6PVI3; -.
DR   TreeFam; TF313897; -.
DR   PathwayCommons; A6PVI3; -.
DR   SignaLink; A6PVI3; -.
DR   BioGRID-ORCS; 392517; 0 hits in 112 CRISPR screens.
DR   GenomeRNAi; 392517; -.
DR   Pharos; A6PVI3; Tdark.
DR   PRO; PR:A6PVI3; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; A6PVI3; protein.
DR   Bgee; ENSG00000170935; Expressed in monocyte and 50 other tissues.
DR   GO; GO:0005846; C:nuclear cap binding complex; IBA:GO_Central.
DR   GO; GO:0000339; F:RNA cap binding; IBA:GO_Central.
DR   GO; GO:0045292; P:mRNA cis splicing, via spliceosome; IEA:InterPro.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   CDD; cd12240; RRM_NCBP2; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR027157; NCBP2.
DR   InterPro; IPR034148; NCBP2_RRM.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR18847; PTHR18847; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..153
FT                   /note="Nuclear cap-binding protein subunit 2-like"
FT                   /id="PRO_0000299538"
FT   DOMAIN          39..116
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
SQ   SEQUENCE   153 AA;  17685 MW;  8AC9525955D22D2A CRC64;
     MSKDLKILCK DPALELSCYR DHQFSGRKFQ QEKLLKESST LNMGNLSFYT TEEKIHELFS
     RSDIRNIFMG LDKIKKTACG FCFVECHNRA DAENAMRFLT GTCLDEWIIC TDWDVGFREG
     QQYGRGKSGG QVRDEFREDF HSGRGGFGRQ TQI