NCBP1_AEDAE
ID NCBP1_AEDAE Reviewed; 813 AA.
AC Q16UN6;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 89.
DE RecName: Full=Nuclear cap-binding protein subunit 1;
DE AltName: Full=80 kDa nuclear cap-binding protein;
DE Short=CBP80;
DE Short=NCBP 80 kDa subunit;
GN Name=Cbp80; ORFNames=AAEL009839;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: Component of the cap-binding complex (CBC), which binds
CC cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in
CC various processes such as pre-mRNA splicing and RNA-mediated gene
CC silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA
CC interference and is required for primary microRNAs (miRNAs) processing.
CC Also involved in innate immunity via the short interfering RNAs
CC (siRNAs) processing machinery by restricting the viral RNA production.
CC In the CBC complex, Cbp80 does not bind directly capped RNAs (m7GpppG-
CC capped RNA) but is required to stabilize the movement of the N-terminal
CC loop of Cbp20 and lock the CBC into a high affinity cap-binding state
CC with the cap structure (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the nuclear cap-binding complex (CBC), a
CC heterodimer composed of Cbp80 and Cbp20 that interacts with m7GpppG-
CC capped RNA. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NCBP1 family. {ECO:0000305}.
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DR EMBL; CH477617; EAT38244.1; -; Genomic_DNA.
DR RefSeq; XP_001660456.1; XM_001660406.1.
DR AlphaFoldDB; Q16UN6; -.
DR SMR; Q16UN6; -.
DR STRING; 7159.AAEL009839-PA; -.
DR GeneID; 5572517; -.
DR KEGG; aag:5572517; -.
DR VEuPathDB; VectorBase:AAEL009839; -.
DR eggNOG; KOG1104; Eukaryota.
DR HOGENOM; CLU_013207_0_0_1; -.
DR InParanoid; Q16UN6; -.
DR OMA; QPFKIPF; -.
DR OrthoDB; 270650at2759; -.
DR PhylomeDB; Q16UN6; -.
DR Proteomes; UP000008820; Chromosome 3.
DR GO; GO:0005846; C:nuclear cap binding complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000339; F:RNA cap binding; IEA:InterPro.
DR GO; GO:0006370; P:7-methylguanosine mRNA capping; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027159; CBP80.
DR InterPro; IPR015172; MIF4G-like_typ-1.
DR InterPro; IPR015174; MIF4G-like_typ-2.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR PANTHER; PTHR12412; PTHR12412; 1.
DR Pfam; PF02854; MIF4G; 1.
DR Pfam; PF09088; MIF4G_like; 1.
DR Pfam; PF09090; MIF4G_like_2; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; SSF48371; 3.
PE 3: Inferred from homology;
KW mRNA capping; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW RNA-mediated gene silencing.
FT CHAIN 1..813
FT /note="Nuclear cap-binding protein subunit 1"
FT /id="PRO_0000385230"
FT DOMAIN 31..243
FT /note="MIF4G"
FT REGION 667..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..716
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 813 AA; 95126 MW; 32AECEE44EF083F8 CRC64;
MNRRRAYEDD GDFYGERSRK RRRVSENQEM EERLETLILR VGENSSSSLE SNLEGLVSVL
ESDLGNFRSK ILRILSECPI KMPEKCTIYS TMVGLMNAKN YNFGGEFVDH MVKTFKESLK
QCRWDAARYA LRFLSDLVNC HVISTNSLLQ LLDNMVDAAN EDSVPQVRRD WYVFAVLSTL
PWVGRELYEK KESALENLLV RIEVFLNKRT KKHHNSLRVW SVDAPHPQEE YLDCLWAQIR
KLRQDNWAEK HIPRPYLAFD SVLCEALQHN LPLIHPPPHQ DSFEYPMPWV VYRMFDYTDC
PAGPILPGAH SIERFLIEEH LHSIIEAHHW ERKDCAANLL NLSYKDKIPL EYCIVEVIFA
ELFKMPTPRY LDICYGSILI ELCKLQPSKM PQVLAQATEI LFMRIDSMNT SCFDRFANWF
SYHLSNFQFR WSWDDWDSCL LLEPEHPRPK FIEEVLLKCL RLSYHDRFKE MMPETYSKLI
PKPPMPTYKY TMEGAASLPG TATAHKLVVA IRQKCTPEDV LNELKDLPNP RETSENDMVE
STFNPLKIDV FVQTLLNLGS KSFSHTFAAI SKFHLVFKTL AETEEAQICI LHNVFELWVN
HQQMMVVIID KLLKTQIVEC SAVATWVFSK EMVGEFTKMY LWEILHLTIK KMNQHVTKLS
KELSDAKERL DRNAESSSSE SEEETAPAGT DAVTPQRRRK KPIGDNADKP TEEQVERMEE
KLEAAYVDQK RLFLIIFQRF IMILSEHLVK CDTDGRDYDT DWYRWTVGRL QQVFMMHHEQ
VKKYSSTLES LLFTSDIDPH ILDVFHQFTA LRS
