NCBP1_ASHGO
ID NCBP1_ASHGO Reviewed; 860 AA.
AC Q754H6;
DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2013, sequence version 2.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Nuclear cap-binding protein complex subunit 1;
DE AltName: Full=80 kDa nuclear cap-binding protein;
DE Short=CBP80;
DE Short=NCBP 80 kDa subunit;
GN Name=CBC1; OrderedLocusNames=AFR218W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION, AND SEQUENCE REVISION TO 20-21 AND 28-35.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Component of the cap-binding complex (CBC) involved in the
CC nuclear export of capped U snRNAs. The CBC complex is required for
CC efficient pre-mRNA splicing through efficient commitment complex and
CC spliceosome formation; and involved in rRNA processing at sites A0, A1
CC and A2 (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the nuclear cap-binding complex (CBC).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NCBP1 family. {ECO:0000305}.
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DR EMBL; AE016819; AAS53589.2; -; Genomic_DNA.
DR RefSeq; NP_985765.2; NM_211119.2.
DR AlphaFoldDB; Q754H6; -.
DR SMR; Q754H6; -.
DR STRING; 33169.AAS53589; -.
DR EnsemblFungi; AAS53589; AAS53589; AGOS_AFR218W.
DR GeneID; 4622027; -.
DR KEGG; ago:AGOS_AFR218W; -.
DR eggNOG; KOG1104; Eukaryota.
DR HOGENOM; CLU_011380_0_0_1; -.
DR InParanoid; Q754H6; -.
DR OMA; QPFKIPF; -.
DR Proteomes; UP000000591; Chromosome VI.
DR GO; GO:0000243; C:commitment complex; IEA:EnsemblFungi.
DR GO; GO:0005845; C:mRNA cap binding complex; IBA:GO_Central.
DR GO; GO:0005846; C:nuclear cap binding complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005844; C:polysome; IEA:EnsemblFungi.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0000339; F:RNA cap binding; IBA:GO_Central.
DR GO; GO:0006370; P:7-methylguanosine mRNA capping; IEA:UniProtKB-KW.
DR GO; GO:0031124; P:mRNA 3'-end processing; IEA:EnsemblFungi.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:EnsemblFungi.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:EnsemblFungi.
DR GO; GO:0042789; P:mRNA transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IBA:GO_Central.
DR GO; GO:0006970; P:response to osmotic stress; IEA:EnsemblFungi.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027159; CBP80.
DR InterPro; IPR015172; MIF4G-like_typ-1.
DR InterPro; IPR015174; MIF4G-like_typ-2.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR PANTHER; PTHR12412; PTHR12412; 1.
DR Pfam; PF09088; MIF4G_like; 1.
DR Pfam; PF09090; MIF4G_like_2; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; SSF48371; 3.
PE 3: Inferred from homology;
KW mRNA capping; mRNA processing; mRNA splicing; mRNA transport; Nucleus;
KW Reference proteome; Ribosome biogenesis; RNA-binding; rRNA processing;
KW Transport.
FT CHAIN 1..860
FT /note="Nuclear cap-binding protein complex subunit 1"
FT /id="PRO_0000232992"
FT DOMAIN 36..271
FT /note="MIF4G"
SQ SEQUENCE 860 AA; 99442 MW; 8FDBAEDC5495D4A5 CRC64;
MSGMKRRYDY EEEDGYRDFR PRYSKRQRLP PVVQLCKDML PDIRTIGESV KAFEEDIKFL
SEAIINEFGN DEYFNNALLS TFNALILEQP HKQPAIALLT IVVNSGNPAA GKSVINYFYE
KLQHLLDMTV VDDFEVTSNE TGPWNKIKLT LRFLSLLSPV ITLTELTNVY QRLFELAVQL
NRSSDANTRN PLSEAIYTNT LLNIPYLFFF NKEDETLRTN VEDLIQYAES NYEVKTVDLS
LTKEYNKNLP YEPVQWVQIV LSNVKNALAN DMEELKNLFP DYQNLLPTSI EQQMFNDPLT
IPEFEKLLPF SGLDKGLGSV DSMWKTPRTA FQVYLPNVVG DFSTVVPITT YTGMLFDDII
VDIVESLEFN RHEVARQVVT LDLYFKPGIF TEPGLSIAQL LVQHNEMPEL STYKIEDLAI
ENILGLIFKL PTVTQSFAYF YTLLVEICQN SPKAIAPVFG RAFRLFYNNL DNMDHELKMR
YLDWFSIQMS NFNFSWKWNE WEQDSIAFSK SFYNPKITFA KNLIRKELRL TSNRPDVEDS
LTPEFKQYLD ASYISKDQLA SYYQSFFEGF SFDPEVIKDN DLLFKNEVFP FHEKVQLILD
YIHKQPLEKN ISELESLLED IKSAHGDKIP DFNRFTVTLL IQALVYSGNR SLSHANKYIS
DAKSDLVTIL EKMEVPPEVK EQWIIEAVIR YWNCNSQNGF LIVDSFKHSE LVTAKSILTF
SLTDLNGQNL GLVDATSIES TFRTLTELAL QQASDISVFE FVFERLLEII NDTVSQLGTN
EEIVAPSVDN ETMLDVDELA RLDLIWKYES AVGFIKSILR KYSDEYSVLL DKFSAGLEQA
VPHEPTRKQL DQWFNEIREL
