ID   NCBP1_CAEBR             Reviewed;         793 AA.
AC   A8XG63;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 3.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Nuclear cap-binding protein subunit 1;
DE   AltName: Full=80 kDa nuclear cap-binding protein;
DE            Short=CBP80;
DE            Short=NCBP 80 kDa subunit;
GN   Name=ncbp-1; Synonyms=cbp-80; ORFNames=CBG12621;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the cap-binding complex (CBC), which binds
CC       cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in
CC       various processes such as pre-mRNA splicing and RNA-mediated gene
CC       silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA
CC       interference and is required for primary microRNAs (miRNAs) processing.
CC       In the CBC complex, ncbp-1 does not bind directly capped RNAs (m7GpppG-
CC       capped RNA) but is required to stabilize the movement of the N-terminal
CC       loop of ncbp-2 and lock the CBC into a high affinity cap-binding state
CC       with the cap structure (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the nuclear cap-binding complex (CBC), a
CC       heterodimer composed of ncbp-1 and ncbp-1 that interacts with m7GpppG-
CC       capped RNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NCBP1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAP31569.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; HE600940; CAP31569.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_002640122.1; XM_002640076.1.
DR   AlphaFoldDB; A8XG63; -.
DR   SMR; A8XG63; -.
DR   STRING; 6238.CBG12621; -.
DR   EnsemblMetazoa; CBG12621.1; CBG12621.1; WBGene00033539.
DR   GeneID; 8582118; -.
DR   CTD; 8582118; -.
DR   WormBase; CBG12621; CBP17552; WBGene00033539; Cbr-ncbp-1.
DR   eggNOG; KOG1104; Eukaryota.
DR   HOGENOM; CLU_013207_0_0_1; -.
DR   InParanoid; A8XG63; -.
DR   OrthoDB; 270650at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0005845; C:mRNA cap binding complex; IBA:GO_Central.
DR   GO; GO:0005846; C:nuclear cap binding complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0000339; F:RNA cap binding; IBA:GO_Central.
DR   GO; GO:0006370; P:7-methylguanosine mRNA capping; IEA:UniProtKB-KW.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR   GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IBA:GO_Central.
DR   GO; GO:0031053; P:primary miRNA processing; IEA:EnsemblMetazoa.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR027159; CBP80.
DR   InterPro; IPR015172; MIF4G-like_typ-1.
DR   InterPro; IPR015174; MIF4G-like_typ-2.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   PANTHER; PTHR12412; PTHR12412; 1.
DR   Pfam; PF02854; MIF4G; 1.
DR   Pfam; PF09088; MIF4G_like; 1.
DR   Pfam; PF09090; MIF4G_like_2; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; SSF48371; 3.
PE   3: Inferred from homology;
KW   mRNA capping; mRNA processing; mRNA splicing; Nucleus; Reference proteome;
KW   RNA-mediated gene silencing.
FT   CHAIN           1..793
FT                   /note="Nuclear cap-binding protein subunit 1"
FT                   /id="PRO_0000385243"
FT   DOMAIN          28..242
FT                   /note="MIF4G"
SQ   SEQUENCE   793 AA;  91762 MW;  D7F7D4502A7B9771 CRC64;
     MSRRRQNDEE DEIQMKRRRG APLIGDVEKK LQEVIGKVGD KNTGSSIEAN LEKLTAFLHD
     DLEKYRSSII DIVAGCAIYL PNRVTVYTTL VGLLNAKNFN FGGDVVEKLI AEQQDLLLKQ
     KYQEAQNLAI FLCDLGNSGV LTAQSIGEYL ESFIAAAFEE NMPQVRNDYY IQTVLRCLPW
     IGKELTEKAQ EQMENIVEAV GKYLEMRNKN HVPLLRVWRE GSTDQEQEDY LESLSAQIEN
     LRTANWMQNH IPRYYNTFEA VLQDALQHNL PSFSSPEHTS DMIYPYPLVV FRLFQDADCG
     TDSQLPSGHS IDRFLFEGEI SWIIEKNQFN RKSCARELLA FADENPTAPV GFLIFETIFG
     QMLRLPHAPY PAIFHCSLVL ELLKLKPNDY PNILCKTVDL IFSRADSMQP ICIDRMVDWF
     SFHLSNFQYR YTWDEWKDCI SNDEFSGRQV FLREVIEKCR RLGSYEKIIA ALPSDFVKIH
     PASPEIRYLL DEEDAMSQRA ETFTQMFQER QPADAFLKEL KSTDENDELP YNINEFGVFV
     TVMLKMASKT YSHNFSALFR YKDTLKTVCD AAEQYQEKLL ETLYSCWKSN QQMLMILTDK
     LLKMQIIDCS SVVGWLFDEK MWQEHNRQWL FEVLNQALEK LTRQINVVEK DIKDLTEKVE
     SKEKVTEAGD VKMEEETVVD EKLKGEMEEL ENHKEKLDRM VSFQRNLFND FLIAFVEEIK
     SAATNTSEMD GSGDVGGSES SKFLWLRGRF CHVLLAHAET LLKHSSSIAE EVFSEGADPN
     ISECFNQFQS LRF