ID   A19_VACCW               Reviewed;          77 AA.
AC   P68714; Q76ZP9;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   29-SEP-2021, entry version 37.
DE   RecName: Full=Protein A19;
GN   OrderedLocusNames=VACWR139; ORFNames=A19L;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=23885081; DOI=10.1128/jvi.01258-13;
RA   Satheshkumar P.S., Weisberg A.S., Moss B.;
RT   "Vaccinia virus A19 protein participates in the transformation of spherical
RT   immature particles to barrel-shaped infectious virions.";
RL   J. Virol. 87:10700-10709(2013).
RN   [3]
RP   SUBCELLULAR LOCATION, FUNCTION, AND INTERACTION WITH RAP94; RPO147; RPO132;
RP   E6; A7; D1; D11; A12; A3 AND E2.
RX   PubMed=23885084; DOI=10.1128/jvi.01261-13;
RA   Satheshkumar P.S., Olano L.R., Hammer C.H., Zhao M., Moss B.;
RT   "Interactions of the vaccinia virus A19 protein.";
RL   J. Virol. 87:10710-10720(2013).
CC   -!- FUNCTION: Plays a role in the maturation of immature virions to
CC       infectious particles. May also participate in viral transcription.
CC       {ECO:0000269|PubMed:23885081, ECO:0000269|PubMed:23885084}.
CC   -!- SUBUNIT: Interacts with capping enzyme RAP94, the two large RNA
CC       polymerase subunits RPO147 and RPO132, the two early transcription
CC       factor subunits E6 and A7, one of the capping enzyme subunits D1, the
CC       nucleoside triphosphate phosphohydrolase D11, two core proteins A12 and
CC       A3, and a virion protein E2. {ECO:0000269|PubMed:23885084}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:23885081}. Host
CC       cytoplasm {ECO:0000269|PubMed:23885084}. Host nucleus
CC       {ECO:0000269|PubMed:23885084}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A19 family. {ECO:0000305}.
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DR   EMBL; AY243312; AAO89418.1; -; Genomic_DNA.
DR   RefSeq; YP_233021.1; NC_006998.1.
DR   DNASU; 3707669; -.
DR   GeneID; 3707669; -.
DR   KEGG; vg:3707669; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IDA:UniProtKB.
DR   GO; GO:0042025; C:host cell nucleus; IDA:UniProtKB.
DR   GO; GO:0044423; C:virion component; IDA:UniProtKB.
DR   GO; GO:0019083; P:viral transcription; IDA:UniProtKB.
DR   GO; GO:0019068; P:virion assembly; IDA:UniProtKB.
DR   InterPro; IPR007769; Poxvirus_A19.
DR   Pfam; PF05077; DUF678; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host nucleus; Reference proteome; Virion.
FT   CHAIN           1..77
FT                   /note="Protein A19"
FT                   /id="PRO_0000099263"
SQ   SEQUENCE   77 AA;  8342 MW;  50F134DEC3B9FB69 CRC64;
     MDSTNVRSGM KSRKKKPKTT VIDDDDDCMT CSACQSKLVK ISDITKVSLD YINTMRGNTL
     ACAACGSSLK LLNDFAS