ID   NCCB_ALCXX              Reviewed;         397 AA.
AC   Q44585;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Nickel-cobalt-cadmium resistance protein NccB;
GN   Name=nccB;
OS   Alcaligenes xylosoxydans xylosoxydans (Achromobacter xylosoxidans).
OG   Plasmid pTOM9.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Achromobacter.
OX   NCBI_TaxID=85698;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=31A;
RX   PubMed=7961470; DOI=10.1128/jb.176.22.7045-7054.1994;
RA   Schmidt T., Schlegel H.G.;
RT   "Combined nickel-cobalt-cadmium resistance encoded by the ncc locus of
RT   Alcaligenes xylosoxidans 31A.";
RL   J. Bacteriol. 176:7045-7054(1994).
CC   -!- FUNCTION: Component of the NCC cation efflux system that confers
CC       resistance to nickel, cobalt and cadmium.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC       family. {ECO:0000305}.
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DR   EMBL; L31363; AAA65105.1; -; Genomic_DNA.
DR   PIR; I39579; I39579.
DR   AlphaFoldDB; Q44585; -.
DR   SMR; Q44585; -.
DR   TCDB; 2.A.6.1.12; the resistance-nodulation-cell division (rnd) superfamily.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046686; P:response to cadmium ion; IEA:UniProtKB-KW.
DR   InterPro; IPR005695; Co/Zn/Cd_resistance_CzcB.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   TIGRFAMs; TIGR00999; 8a0102; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
KW   Cadmium; Cadmium resistance; Cell inner membrane; Cell membrane; Cobalt;
KW   Coiled coil; Membrane; Nickel; Plasmid; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..397
FT                   /note="Nickel-cobalt-cadmium resistance protein NccB"
FT                   /id="PRO_0000201888"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          137..195
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   397 AA;  39933 MW;  C6DE57CE314996B8 CRC64;
     MMTKNERRQP SWPMIAGVAA AAALVGFGAA RGLGSPSGAE VSKLAAAPEK AAASAPAAEP
     AEVRIPGEYL AAANIAVEPV SAGGVGSVLL APASVAAVPG SEAVIASRAA GAVLRIQRKL
     GDAVRAGDVL ALVDSPEAAA MAAERKVAQA RADLARKTYE RESSLFQQGV TPRQEMESAR
     IALDVAQAEV QRAATVAQAA KVSSDGRSVA VVSPIAGRIT AQSVTLGAYV APQAELFRVA
     GSGAVQVEAY VTAADTSRIA AGSDATIVLA NGAPLAGRVQ AVTPTVSGSA RAATVVVTPV
     DANSGLIVGE GVQVRLHTKA ADANAMSVPE DAVQNLDGRD VVFVRTQQGF RPKSVLVGSR
     SGGVAQILSG VKPGEQVATR NAFLIKAEMN KAGGDDE