ID   NCCC_ALCXX              Reviewed;         437 AA.
AC   Q44584;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Nickel-cobalt-cadmium resistance protein NccC;
DE   Flags: Precursor;
GN   Name=nccC;
OS   Alcaligenes xylosoxydans xylosoxydans (Achromobacter xylosoxidans).
OG   Plasmid pTOM9.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Achromobacter.
OX   NCBI_TaxID=85698;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=31A;
RX   PubMed=7961470; DOI=10.1128/jb.176.22.7045-7054.1994;
RA   Schmidt T., Schlegel H.G.;
RT   "Combined nickel-cobalt-cadmium resistance encoded by the ncc locus of
RT   Alcaligenes xylosoxidans 31A.";
RL   J. Bacteriol. 176:7045-7054(1994).
CC   -!- FUNCTION: Component of the NCC cation-efflux system that confers
CC       resistance to nickel, cobalt and cadmium.
CC   -!- SIMILARITY: Belongs to the outer membrane factor (OMF) (TC 1.B.17)
CC       family. {ECO:0000305}.
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DR   EMBL; L31363; AAA65104.1; -; Genomic_DNA.
DR   PIR; I39578; I39578.
DR   AlphaFoldDB; Q44584; -.
DR   SMR; Q44584; -.
DR   TCDB; 2.A.6.1.12; the resistance-nodulation-cell division (rnd) superfamily.
DR   GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046686; P:response to cadmium ion; IEA:UniProtKB-KW.
DR   InterPro; IPR003423; OMP_efflux.
DR   Pfam; PF02321; OEP; 2.
PE   3: Inferred from homology;
KW   Cadmium; Cadmium resistance; Cobalt; Nickel; Plasmid; Signal; Transport.
FT   SIGNAL          1..48
FT                   /evidence="ECO:0000255"
FT   CHAIN           49..437
FT                   /note="Nickel-cobalt-cadmium resistance protein NccC"
FT                   /id="PRO_0000021792"
SQ   SEQUENCE   437 AA;  46104 MW;  F83154E083F28CD3 CRC64;
     MGAVLKAEAN IFRSHPFRPM NQATPKKLRS APCIGVALLL MATGSIQAAE APPYSVLLQQ
     SLAMAPTMMV QAANVRAAGA DAAQARAWLN PRFDTLAENL GAPSSGGQSQ RQNTYSITQP
     FEIGGKRGAR IEVGERNYEA AQARERQLRV NYAAELAVAY ATAEAAFGRQ ALAEENLALA
     NEELTVARAL VETGKEATLR TAQAQASVSA AQAIEAAASS DVTSTLARLS ALSGATEAYT
     GISSSLLSAQ PAMTPGGTTT DDSPAVRTAE AERNAFDAQV NVERKRWIPE VGITAGVRRY
     GWSNESGYIV GLTASIPLFD RNRNGIDAAV QRVAAAQARL DTVRLEANAA RRSAVSQVAA
     TDKQLAAASQ GEQAASEAYR VGRLGYEAGK TPLVELLAVR RALVDARQLT IDARLARVRA
     LAALAQADGR LAFEESR