ID   NCCN_ALCXX              Reviewed;         213 AA.
AC   Q44587;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Nickel-cobalt-cadmium resistance protein NccN;
GN   Name=nccN;
OS   Alcaligenes xylosoxydans xylosoxydans (Achromobacter xylosoxidans).
OG   Plasmid pTOM9.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Achromobacter.
OX   NCBI_TaxID=85698;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=31A;
RX   PubMed=7961470; DOI=10.1128/jb.176.22.7045-7054.1994;
RA   Schmidt T., Schlegel H.G.;
RT   "Combined nickel-cobalt-cadmium resistance encoded by the ncc locus of
RT   Alcaligenes xylosoxidans 31A.";
RL   J. Bacteriol. 176:7045-7054(1994).
CC   -!- FUNCTION: Component of the NCC cation-efflux system that confers
CC       resistance to nickel, cobalt and cadmium. Appears to be involved in
CC       metal specificity but affects only nickel resistance. May be involved
CC       in nickel transport.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: To A.eutrophus CzcN. {ECO:0000305}.
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DR   EMBL; L31363; AAA65107.1; -; Genomic_DNA.
DR   PIR; I39581; I39581.
DR   AlphaFoldDB; Q44587; -.
DR   SMR; Q44587; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004671; F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0046686; P:response to cadmium ion; IEA:UniProtKB-KW.
DR   InterPro; IPR007269; ICMT_MeTrfase.
DR   Pfam; PF04140; ICMT; 1.
PE   4: Predicted;
KW   Cadmium; Cadmium resistance; Cell inner membrane; Cell membrane; Cobalt;
KW   Membrane; Nickel; Plasmid; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..213
FT                   /note="Nickel-cobalt-cadmium resistance protein NccN"
FT                   /id="PRO_0000096756"
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   213 AA;  23655 MW;  00203DF84B2CD374 CRC64;
     MNISLRPAIA APSPLDSFLT RHRIGIWRVV VSVVLIALIT GHSQWDDTWI SAALLTVGML
     GVTMATVGRL WCALYISGRK STELVTTGPY SMCRHPLYVC NFVGIVGLGA MTESITLAAI
     LALAFALMYP AVIRSEDHLL SRNFPEFDDY ARRTPAFFPR LSLFRSESTY LVHVGSFQRN
     LADSVWFLGM TIVVNAVELA RHAKWLPTFV LLP