ID   NCCX_ALCXX              Reviewed;         148 AA.
AC   Q44582;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Nickel-cobalt-cadmium resistance protein NccX;
GN   Name=nccX;
OS   Alcaligenes xylosoxydans xylosoxydans (Achromobacter xylosoxidans).
OG   Plasmid pTOM9.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Achromobacter.
OX   NCBI_TaxID=85698;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=31A;
RX   PubMed=7961470; DOI=10.1128/jb.176.22.7045-7054.1994;
RA   Schmidt T., Schlegel H.G.;
RT   "Combined nickel-cobalt-cadmium resistance encoded by the ncc locus of
RT   Alcaligenes xylosoxidans 31A.";
RL   J. Bacteriol. 176:7045-7054(1994).
CC   -!- FUNCTION: Component of the NCC cation-efflux system that confers
CC       resistance to nickel, cobalt and cadmium. May be involved in the
CC       regulation of NCC.
CC   -!- SIMILARITY: To A.eutrophus CnrR. {ECO:0000305}.
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DR   EMBL; L31363; AAA65102.1; -; Genomic_DNA.
DR   PIR; I39576; I39576.
DR   PDB; 4CLV; X-ray; 3.12 A; A/B=1-148.
DR   PDBsum; 4CLV; -.
DR   AlphaFoldDB; Q44582; -.
DR   SMR; Q44582; -.
DR   GO; GO:0046686; P:response to cadmium ion; IEA:UniProtKB-KW.
DR   InterPro; IPR025961; Metal_resist.
DR   Pfam; PF13801; Metal_resist; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cadmium; Cadmium resistance; Cobalt; Nickel; Plasmid.
FT   CHAIN           1..148
FT                   /note="Nickel-cobalt-cadmium resistance protein NccX"
FT                   /id="PRO_0000096757"
FT   HELIX           8..48
FT                   /evidence="ECO:0007829|PDB:4CLV"
FT   HELIX           55..88
FT                   /evidence="ECO:0007829|PDB:4CLV"
FT   HELIX           96..125
FT                   /evidence="ECO:0007829|PDB:4CLV"
FT   HELIX           129..144
FT                   /evidence="ECO:0007829|PDB:4CLV"
SQ   SEQUENCE   148 AA;  16685 MW;  BC9F99F54271B830 CRC64;
     MMKSRTFRLS VSTLVGALVG VLMAIVGVYV THSTEEPHTS LHEMLHDAVP LDSNEREILE
     LKEEEFTARR REIESRLRAA NGKLAESIAK NPQWSPEVEE ATREVERAAA DLQRATLVHV
     FEMRAGLKPE HRAAYDRVLV DALKRGSQ