NCDN_DROME
ID NCDN_DROME Reviewed; 723 AA.
AC Q9VI25; Q8MSV0;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Neurochondrin homolog;
DE AltName: Full=dNeurochondrin;
GN Name=Neurochondrin; ORFNames=CG2330;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 431-723.
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION, PROBABLE FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16415344; DOI=10.1074/jbc.m512468200;
RA Montana E.S., Littleton J.T.;
RT "Expression profiling of a hypercontraction-induced myopathy in Drosophila
RT suggests a compensatory cytoskeletal remodeling response.";
RL J. Biol. Chem. 281:8100-8109(2006).
CC -!- FUNCTION: Strongly up-regulated in Mhc mutants suggesting a role in
CC muscle function.
CC -!- TISSUE SPECIFICITY: Expressed in both somatic and visceral musculature.
CC {ECO:0000269|PubMed:16415344}.
CC -!- SIMILARITY: Belongs to the neurochondrin family. {ECO:0000305}.
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DR EMBL; AE014297; AAF54119.1; -; Genomic_DNA.
DR EMBL; AY118571; AAM49940.2; -; mRNA.
DR RefSeq; NP_649658.1; NM_141401.2.
DR AlphaFoldDB; Q9VI25; -.
DR SMR; Q9VI25; -.
DR BioGRID; 65997; 3.
DR STRING; 7227.FBpp0081226; -.
DR PaxDb; Q9VI25; -.
DR PRIDE; Q9VI25; -.
DR DNASU; 40796; -.
DR EnsemblMetazoa; FBtr0081729; FBpp0081226; FBgn0037447.
DR GeneID; 40796; -.
DR KEGG; dme:Dmel_CG2330; -.
DR UCSC; CG2330-RA; d. melanogaster.
DR CTD; 40796; -.
DR FlyBase; FBgn0037447; Neurochondrin.
DR VEuPathDB; VectorBase:FBgn0037447; -.
DR eggNOG; KOG2611; Eukaryota.
DR GeneTree; ENSGT00390000013601; -.
DR HOGENOM; CLU_012443_0_0_1; -.
DR InParanoid; Q9VI25; -.
DR OMA; DRKYELC; -.
DR OrthoDB; 311670at2759; -.
DR PhylomeDB; Q9VI25; -.
DR BioGRID-ORCS; 40796; 0 hits in 1 CRISPR screen.
DR ChiTaRS; Neurochondrin; fly.
DR GenomeRNAi; 40796; -.
DR PRO; PR:Q9VI25; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0037447; Expressed in crop (Drosophila) and 26 other tissues.
DR ExpressionAtlas; Q9VI25; baseline and differential.
DR Genevisible; Q9VI25; DM.
DR GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR GO; GO:0043025; C:neuronal cell body; ISS:UniProtKB.
DR GO; GO:0003012; P:muscle system process; IGI:FlyBase.
DR GO; GO:0031175; P:neuron projection development; IBA:GO_Central.
DR GO; GO:0048168; P:regulation of neuronal synaptic plasticity; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR008709; Neurochondrin.
DR PANTHER; PTHR13109; PTHR13109; 1.
DR Pfam; PF05536; Neurochondrin; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..723
FT /note="Neurochondrin homolog"
FT /id="PRO_0000324622"
SQ SEQUENCE 723 AA; 81629 MW; 66BDE6EDD95E1462 CRC64;
MTDVPEPVRK CASLLKGTKS DTEKFAALFM VTKLVKGKDC NAAGKKLLFE AIGFPFLKKL
LVSKDLPNDC PPLVYKSVAL SILTCFCQEE ELATHKDIID AIPTLLEIVE QADDEDYEDN
LIVVSEAYSC LKSIASHEPG QQALLATGAI PKMSQIYSAQ SFQTDEALHL IVLLVKQFGV
VSWPEDPTAF HALIQRIALD METDDTERKY ELCRILADIL ITCRREIVIN SLEGQIWPES
LFKGCGDILK AKIGPKQRDP ALHLIATTLH VLGIQWAFMD EQKTFFLQLL QLGAIEVRMQ
MDEKKLETTF KQAELLTCCF SILEHCIEYM ATDQLDLEPK EKQTTYTALK GAFNQVLAVL
TRVSQDKIRE SSNPKDKKFV FAIVKVLSAW LAQETTAMRP AIYKLLPFML KVANESFQEL
KTWRAGTREG EPPIDVLRIM LPALCHFAVE EEARRVLFTH KQDEVLLESL EFYFSIAHWK
RPPIPRAERL KRMNEPDPVP TPEQQAEMKV ARSAIVALCN ILMNFTVLEP KKAEDGPTFA
NLLKFVVENL PELKDTPDNL VIHGNLAVLG LLLLKQQSKK VKQNDFSICR YIQATIRFLW
DAYNIDESND PTALVVSIAY KGYWSDLSEL WFLGMQTMCG VLPLVPWLSE FALESGWAEG
IVKTLKKVKI GTLPANVKSA YEDFLSQLVD VNGDVQAVLK KADALRVCRN HRMMDLGKKL
FGD
