NCE1_YEAST
ID NCE1_YEAST Reviewed; 53 AA.
AC Q02820; D6VVY9; O00037; O00038;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Non-classical export protein 1;
GN Name=NCE101; Synonyms=NCE1; OrderedLocusNames=YJL205C;
GN ORFNames=YJL205BC, YJL205C-A;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=ATCC 26109 / X2180;
RX PubMed=8655575; DOI=10.1083/jcb.133.5.1017;
RA Cleves A.E., Cooper D.N.W., Barondes S.H., Kelly R.B.;
RT "A new pathway for protein export in Saccharomyces cerevisiae.";
RL J. Cell Biol. 133:1017-1026(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7754713; DOI=10.1002/yea.320100912;
RA Purnelle B., Coster F., Goffeau A.;
RT "The sequence of a 36 kb segment on the left arm of yeast chromosome X
RT identifies 24 open reading frames including NUC1, PRP21 (SPP91), CDC6,
RT CRY2, the gene for S24, a homologue to the aconitase gene ACO1 and two
RT homologues to chromosome III genes.";
RL Yeast 10:1235-1249(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- FUNCTION: Involved in a novel pathway of export of proteins that lack a
CC cleavable signal sequence. May be part of the export machinery or may
CC also be a substrate for non-classical export.
CC {ECO:0000269|PubMed:8655575}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NCE101 family. {ECO:0000305}.
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DR EMBL; U41658; AAC49349.1; -; mRNA.
DR EMBL; Z49480; CAA89500.1; -; Genomic_DNA.
DR EMBL; Z49481; CAA89503.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08605.1; -; Genomic_DNA.
DR PIR; S61953; S61953.
DR RefSeq; NP_012330.1; NM_001181639.1.
DR AlphaFoldDB; Q02820; -.
DR SMR; Q02820; -.
DR BioGRID; 33553; 114.
DR IntAct; Q02820; 1.
DR STRING; 4932.YJL205C; -.
DR TCDB; 9.A.27.1.1; the non-classical protein exporter (ncpe) family.
DR MaxQB; Q02820; -.
DR PaxDb; Q02820; -.
DR PRIDE; Q02820; -.
DR EnsemblFungi; YJL205C_mRNA; YJL205C; YJL205C.
DR GeneID; 853225; -.
DR KEGG; sce:YJL205C; -.
DR SGD; S000003742; NCE101.
DR VEuPathDB; FungiDB:YJL205C; -.
DR eggNOG; ENOG502SBQ0; Eukaryota.
DR HOGENOM; CLU_188578_1_0_1; -.
DR InParanoid; Q02820; -.
DR OMA; KRWNERG; -.
DR BioCyc; YEAST:G3O-31634-MON; -.
DR ChiTaRS; NCE101; yeast.
DR PRO; PR:Q02820; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; Q02820; protein.
DR GO; GO:0005829; C:cytosol; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009306; P:protein secretion; IGI:SGD.
DR InterPro; IPR024242; NCE101.
DR PANTHER; PTHR28011; PTHR28011; 1.
DR Pfam; PF11654; NCE101; 1.
PE 3: Inferred from homology;
KW Membrane; Protein transport; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..53
FT /note="Non-classical export protein 1"
FT /id="PRO_0000096759"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 53 AA; 6337 MW; 05358FA15499E8B2 CRC64;
MVQYAPFLLG KFSDPLLAIM VGCLSYYVYE RKMGRPQGHH LHELIKKRWD DRK
