NCE2_CANAL
ID NCE2_CANAL Reviewed; 170 AA.
AC Q5ANE3; A0A1D8PK31;
DT 01-APR-2015, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Non-classical export protein 102 {ECO:0000305};
GN Name=NCE102 {ECO:0000303|PubMed:24281718};
GN OrderedLocusNames=CAALFM_C304910CA; ORFNames=CaO19.13381, CaO19.5960;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=19824013; DOI=10.1002/pmic.200800988;
RA Cabezon V., Llama-Palacios A., Nombela C., Monteoliva L., Gil C.;
RT "Analysis of Candida albicans plasma membrane proteome.";
RL Proteomics 9:4770-4786(2009).
RN [5]
RP DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=24281718; DOI=10.1128/mbio.00723-13;
RA Douglas L.M., Wang H.X., Konopka J.B.;
RT "The MARVEL domain protein Nce102 regulates actin organization and invasive
RT growth of Candida albicans.";
RL MBio 4:E00723-E00723(2013).
CC -!- FUNCTION: Involved in membrane organization. Involved in a novel
CC pathway of export of proteins that lack a cleavable signal sequence.
CC Non-classical export pathway functions also as an alternative
CC clearance/detoxification pathway to eliminate damaged material, when
CC the basic repair pathway is not sufficient (By similarity). Regulates
CC actin organization and subsequent morphogenesis and pathogenesis.
CC {ECO:0000250|UniProtKB:Q12207, ECO:0000269|PubMed:24281718}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19824013};
CC Multi-pass membrane protein {ECO:0000255}. Note=Accumulates in membrane
CC domains at eisosomes. {ECO:0000250|UniProtKB:Q12207}.
CC -!- DISRUPTION PHENOTYPE: Leads to decreased virulence and forms abnormal
CC hyphae in mice. Shows defects in forming hyphae and invading low
CC concentrations of agar but can invade well in higher agar
CC concentrations. {ECO:0000269|PubMed:24281718}.
CC -!- SIMILARITY: Belongs to the NCE102 family. {ECO:0000305}.
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DR EMBL; CP017625; AOW28507.1; -; Genomic_DNA.
DR RefSeq; XP_723171.1; XM_718078.1.
DR AlphaFoldDB; Q5ANE3; -.
DR STRING; 237561.Q5ANE3; -.
DR PRIDE; Q5ANE3; -.
DR EnsemblFungi; KHC79033; KHC79033; W5Q_03000.
DR EnsemblFungi; KHC87257; KHC87257; I503_02994.
DR GeneID; 3635267; -.
DR KEGG; cal:CAALFM_C304910CA; -.
DR CGD; CAL0000190917; NCE102.
DR VEuPathDB; FungiDB:C3_04910C_A; -.
DR eggNOG; ENOG502RZW2; Eukaryota.
DR HOGENOM; CLU_098356_1_0_1; -.
DR InParanoid; Q5ANE3; -.
DR OMA; QASTAFM; -.
DR OrthoDB; 1421517at2759; -.
DR PHI-base; PHI:4003; -.
DR PRO; PR:Q5ANE3; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0032126; C:eisosome; IDA:CGD.
DR GO; GO:1903561; C:extracellular vesicle; IDA:CGD.
DR GO; GO:0035838; C:growing cell tip; IEA:EnsemblFungi.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:CGD.
DR GO; GO:0030036; P:actin cytoskeleton organization; IMP:CGD.
DR GO; GO:0007015; P:actin filament organization; IMP:CACAO.
DR GO; GO:0070941; P:eisosome assembly; IBA:GO_Central.
DR GO; GO:0007009; P:plasma membrane organization; IEA:EnsemblFungi.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
DR PROSITE; PS51225; MARVEL; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Virulence.
FT CHAIN 1..170
FT /note="Non-classical export protein 102"
FT /id="PRO_0000431765"
FT TOPO_DOM 1..11
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 12..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..38
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 39..61
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 77..97
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..125
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 126..146
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..170
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT DOMAIN 6..141
FT /note="MARVEL"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00581"
SQ SEQUENCE 170 AA; 18123 MW; CB8AC9D732D08858 CRC64;
MLAIGDVILR AFNFVFLVIA LGLTGSLAAT TITQHNPQIN FAVFAAAFGL LTSSFYGVFA
YFVAAFAWPV ILFVFDFLNF VFTFAAATAI AAGIRAHSCS NQDYLDDNNI AQGSSGRCRK
AQASTAFLYF STFIFIASAI FSAISLSKGG LFGHSSRPAP RTGVPTMSQV
