NCE2_SCHPO
ID NCE2_SCHPO Reviewed; 183 AA.
AC O74333;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Non-classical export protein 2 homolog;
GN Name=fhn1; ORFNames=SPBC1685.13;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP FUNCTION.
RX PubMed=20581291; DOI=10.1128/ec.00006-10;
RA Loibl M., Grossmann G., Stradalova V., Klingl A., Rachel R., Tanner W.,
RA Malinsky J., Opekarova M.;
RT "C terminus of Nce102 determines the structure and function of microdomains
RT in the Saccharomyces cerevisiae plasma membrane.";
RL Eukaryot. Cell 9:1184-1192(2010).
CC -!- FUNCTION: Involved in membrane organization and might act as a sensor
CC of sphingolipids that regulates plasma membrane function. Involved in a
CC novel pathway of export of proteins that lack a cleavable signal
CC sequence. {ECO:0000269|PubMed:20581291}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Golgi
CC apparatus membrane {ECO:0000269|PubMed:16823372}; Multi-pass membrane
CC protein {ECO:0000269|PubMed:16823372}. Cell membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NCE102 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA20061.1; -; Genomic_DNA.
DR PIR; T39529; T39529.
DR RefSeq; NP_595217.1; NM_001021124.2.
DR AlphaFoldDB; O74333; -.
DR SMR; O74333; -.
DR BioGRID; 276279; 5.
DR STRING; 4896.SPBC1685.13.1; -.
DR TCDB; 9.A.27.1.3; the non-classical protein exporter (ncpe) family.
DR iPTMnet; O74333; -.
DR SwissPalm; O74333; -.
DR MaxQB; O74333; -.
DR PaxDb; O74333; -.
DR PRIDE; O74333; -.
DR EnsemblFungi; SPBC1685.13.1; SPBC1685.13.1:pep; SPBC1685.13.
DR GeneID; 2539727; -.
DR KEGG; spo:SPBC1685.13; -.
DR PomBase; SPBC1685.13; fhn1.
DR VEuPathDB; FungiDB:SPBC1685.13; -.
DR eggNOG; ENOG502RZW2; Eukaryota.
DR HOGENOM; CLU_098356_1_0_1; -.
DR InParanoid; O74333; -.
DR OMA; QGSGKRC; -.
DR PhylomeDB; O74333; -.
DR PRO; PR:O74333; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0032126; C:eisosome; IDA:PomBase.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035838; C:growing cell tip; IDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IGI:PomBase.
DR GO; GO:0070941; P:eisosome assembly; IMP:PomBase.
DR GO; GO:0007009; P:plasma membrane organization; IGI:PomBase.
DR GO; GO:0072659; P:protein localization to plasma membrane; IGI:PomBase.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR008253; Marvel.
DR Pfam; PF01284; MARVEL; 1.
PE 3: Inferred from homology;
KW Cell membrane; Cytoplasm; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..183
FT /note="Non-classical export protein 2 homolog"
FT /id="PRO_0000350998"
FT TOPO_DOM 1..8
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..44
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..75
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 97..131
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..183
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 163..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 183 AA; 20273 MW; 824C0756BFF3CFF7 CRC64;
MVGIRQYGVF TWVFRTFQLA IDTIVLALAS ALVNQQTSGG SPGKINFSVA VGSFAILTFF
LTAVGRFLPT ILGNPWLIAF YDFVNWVFAL TGGCCIAVAI RVHACDNQKY LDRNHYTQGS
MRRCQELKAL CFFLWFMFGL YVASFIVQIF IAKNDTPNYT FRGRGRGKGS GPAVAPRPVM
SAV
