NCF1B_HUMAN
ID NCF1B_HUMAN Reviewed; 391 AA.
AC A6NI72;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Putative neutrophil cytosol factor 1B;
DE Short=NCF-1B;
DE AltName: Full=Putative SH3 and PX domain-containing protein 1B;
GN Name=NCF1B; Synonyms=SH3PXD1B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
CC -!- FUNCTION: May be required for activation of the latent NADPH oxidase
CC (necessary for superoxide production). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC006995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A6NI72; -.
DR BMRB; A6NI72; -.
DR SMR; A6NI72; -.
DR IntAct; A6NI72; 1.
DR GlyGen; A6NI72; 1 site, 1 O-linked glycan (1 site).
DR BioMuta; HGNC:32522; -.
DR EPD; A6NI72; -.
DR jPOST; A6NI72; -.
DR MassIVE; A6NI72; -.
DR MaxQB; A6NI72; -.
DR PeptideAtlas; A6NI72; -.
DR PRIDE; A6NI72; -.
DR ProteomicsDB; 1249; -.
DR GeneCards; NCF1B; -.
DR HGNC; HGNC:32522; NCF1B.
DR neXtProt; NX_A6NI72; -.
DR InParanoid; A6NI72; -.
DR PhylomeDB; A6NI72; -.
DR PathwayCommons; A6NI72; -.
DR SignaLink; A6NI72; -.
DR Pharos; A6NI72; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A6NI72; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043020; C:NADPH oxidase complex; IBA:GO_Central.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IBA:GO_Central.
DR GO; GO:0045730; P:respiratory burst; IBA:GO_Central.
DR GO; GO:0042554; P:superoxide anion generation; IBA:GO_Central.
DR CDD; cd06887; PX_p47phox; 1.
DR CDD; cd12021; SH3_p47phox_1; 1.
DR CDD; cd12022; SH3_p47phox_2; 1.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR015039; NADPH_oxidase_p47Phox_C.
DR InterPro; IPR035756; NCF1_SH3_1.
DR InterPro; IPR035757; NCF1_SH3_2.
DR InterPro; IPR032136; NECFESHC.
DR InterPro; IPR001655; P47PHOX.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR034909; PX_p47phox.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15706:SF6; PTHR15706:SF6; 1.
DR Pfam; PF16621; NECFESHC; 1.
DR Pfam; PF08944; p47_phox_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 2.
DR PRINTS; PR00498; P47PHOX.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF50044; SSF50044; 2.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 2.
PE 5: Uncertain;
KW Cytoplasm; Phosphoprotein; Reference proteome; Repeat; SH3 domain.
FT CHAIN 1..391
FT /note="Putative neutrophil cytosol factor 1B"
FT /id="PRO_0000349367"
FT DOMAIN 1..126
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT DOMAIN 157..216
FT /note="SH3 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 227..286
FT /note="SH3 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 286..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 304
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P14598"
FT MOD_RES 305
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P14598"
FT MOD_RES 321
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P14598"
FT MOD_RES 329
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P14598"
FT MOD_RES 346
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P14598"
FT MOD_RES 349
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P14598"
SQ SEQUENCE 391 AA; 44817 MW; DD386BF36C25DF9D CRC64;
MGDTFIRHIA LLGFEKRFVP SQHYVRYMFL VKWQDLSEKV VYRRFTEIYE FHKTLKEMFP
IEAGAINPEN RIIPHLPAPK WFDGQRAAEN HQGTLTEYCG TLMSLPTKIS RCPHLLDFFK
VRPDDLKLPT DNQTKKPETY LMPKDGKSTA TDITGPIILQ TYRAIANYEK TSGSEMALST
GDVVEVVEKS ESGWWFCQMK AKRGWIPASF LEPLDSPDET EDPEPNYAGE PYVAIKAYTA
VEGDEVSLLE GEAVEVIHKL LDGWWVIRKD DVTGYFPSMY LQKSGQDVSQ AQRQIKRGAP
PRRSSIRNVH SIHQRSRKRL SQDAYRRNSV RFLQQRRRQA RPGPQSPGSP LEEERQTQRS
KPQPAVPPRP SADLILNRCS ESTKRKLASA V
