NCF1C_HUMAN
ID NCF1C_HUMAN Reviewed; 366 AA.
AC A8MVU1;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Putative neutrophil cytosol factor 1C;
DE Short=NCF-1C;
DE AltName: Full=Putative SH3 and PX domain-containing protein 1C;
GN Name=NCF1C; Synonyms=SH3PXD1C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
CC -!- FUNCTION: May be required for activation of the latent NADPH oxidase
CC (necessary for superoxide production). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC124781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A8MVU1; -.
DR BMRB; A8MVU1; -.
DR SMR; A8MVU1; -.
DR BioMuta; HGNC:32523; -.
DR jPOST; A8MVU1; -.
DR MassIVE; A8MVU1; -.
DR MaxQB; A8MVU1; -.
DR PeptideAtlas; A8MVU1; -.
DR PRIDE; A8MVU1; -.
DR ProteomicsDB; 2205; -.
DR GeneCards; NCF1C; -.
DR HGNC; HGNC:32523; NCF1C.
DR neXtProt; NX_A8MVU1; -.
DR InParanoid; A8MVU1; -.
DR PhylomeDB; A8MVU1; -.
DR ChiTaRS; NCF1C; human.
DR Pharos; A8MVU1; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A8MVU1; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0043020; C:NADPH oxidase complex; IBA:GO_Central.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0016176; F:superoxide-generating NADPH oxidase activator activity; IBA:GO_Central.
DR GO; GO:0045730; P:respiratory burst; IBA:GO_Central.
DR GO; GO:0042554; P:superoxide anion generation; IBA:GO_Central.
DR CDD; cd12021; SH3_p47phox_1; 1.
DR CDD; cd12022; SH3_p47phox_2; 1.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR015039; NADPH_oxidase_p47Phox_C.
DR InterPro; IPR035756; NCF1_SH3_1.
DR InterPro; IPR035757; NCF1_SH3_2.
DR InterPro; IPR032136; NECFESHC.
DR InterPro; IPR001655; P47PHOX.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR15706:SF6; PTHR15706:SF6; 1.
DR Pfam; PF16621; NECFESHC; 1.
DR Pfam; PF08944; p47_phox_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 2.
DR PRINTS; PR00498; P47PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF50044; SSF50044; 2.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 2.
PE 5: Uncertain;
KW Cytoplasm; Phosphoprotein; Reference proteome; Repeat; SH3 domain.
FT CHAIN 1..366
FT /note="Putative neutrophil cytosol factor 1C"
FT /id="PRO_0000349368"
FT DOMAIN 1..101
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT DOMAIN 132..191
FT /note="SH3 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 202..261
FT /note="SH3 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT REGION 261..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 279
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P14598"
FT MOD_RES 280
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P14598"
FT MOD_RES 296
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P14598"
FT MOD_RES 304
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P14598"
FT MOD_RES 321
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P14598"
FT MOD_RES 324
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P14598"
SQ SEQUENCE 366 AA; 41851 MW; 39CFA2C342102DB6 CRC64;
MYMFLVKWQD LSEKVVYRRF TEIYEFHKTL KEMFPIEAGA INPENRIIPH LPAPKWFDGQ
RAAENHQGTL TEYCSTLMSL PTKISRCPHL LDFFKVRPDD LKLPTDNQTK KPETYLMPKD
GKSTATDITG PIILQTYRAI ADYEKTSGSE MALSTGDVVE VVEKSESGWW FCQMKAKRGW
IPASFLEPLD SPDETEDPEP NYAGEPYVAI KAYTAVEGDE VSLLEGEAVE VIHKLLDGWW
VIRKDDVTGY FPSMYLQKSG QDVSQAQRQI KRGAPPRRSS IRNAHSIHQR SRKRLSQDAY
RRNSVRFLQQ RRRQARPGPQ SPGSPLEEER QTQRSKPQPA VPPRPSADLI LNRCSESTKR
KLASAV
