NCMAP_MOUSE
ID NCMAP_MOUSE Reviewed; 100 AA.
AC Q99JS0;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Noncompact myelin-associated protein;
DE AltName: Full=Myelin protein of 11 kDa;
DE Short=MP11;
GN Name=Ncmap;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, Placenta, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TOPOLOGY, GLYCOSYLATION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP INDUCTION.
RX PubMed=18650334; DOI=10.1523/jneurosci.1659-08.2008;
RA Ryu E.J., Yang M., Gustin J.A., Chang L.W., Freimuth R.R., Nagarajan R.,
RA Milbrandt J.;
RT "Analysis of peripheral nerve expression profiles identifies a novel myelin
RT glycoprotein, MP11.";
RL J. Neurosci. 28:7563-7573(2008).
CC -!- FUNCTION: Plays a role in myelin formation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18650334};
CC Single-pass type I membrane protein {ECO:0000269|PubMed:18650334}.
CC Note=Localized mainly in the Schmidt-Lanterman incisures and paranodes
CC of noncompact peripheral nerve myelin. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Found in the peripheral nervous system (PNS)
CC Schwann cells (at protein level). Expressed in the PNS, primarily
CC limited to Schwann cells. {ECO:0000269|PubMed:18650334}.
CC -!- DEVELOPMENTAL STAGE: Expressed in sciatic nerve and placenta at 15.5
CC dpc.
CC -!- INDUCTION: Up-regulated in Schwann cells by EGR2 during nerve
CC development and after nerve injury. {ECO:0000269|PubMed:18650334}.
CC -!- PTM: Glycosylated. {ECO:0000269|PubMed:18650334}.
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DR EMBL; AK014757; BAE20427.1; -; mRNA.
DR EMBL; AK039485; BAC30364.1; -; mRNA.
DR EMBL; AK076488; BAC36364.1; -; mRNA.
DR EMBL; AK167453; BAE39539.1; -; mRNA.
DR EMBL; BC005730; AAH05730.1; -; mRNA.
DR CCDS; CCDS18784.1; -.
DR RefSeq; NP_001161970.1; NM_001168498.1.
DR RefSeq; NP_001161972.1; NM_001168500.1.
DR RefSeq; NP_001230234.1; NM_001243305.1.
DR RefSeq; NP_663530.1; NM_145555.2.
DR RefSeq; NP_851390.1; NM_181047.1.
DR RefSeq; XP_017175649.1; XM_017320160.1.
DR AlphaFoldDB; Q99JS0; -.
DR SMR; Q99JS0; -.
DR STRING; 10090.ENSMUSP00000101485; -.
DR PaxDb; Q99JS0; -.
DR PRIDE; Q99JS0; -.
DR Antibodypedia; 2689; 69 antibodies from 12 providers.
DR Ensembl; ENSMUST00000064481; ENSMUSP00000070780; ENSMUSG00000043924.
DR Ensembl; ENSMUST00000105857; ENSMUSP00000101483; ENSMUSG00000043924.
DR Ensembl; ENSMUST00000105858; ENSMUSP00000101484; ENSMUSG00000043924.
DR Ensembl; ENSMUST00000105859; ENSMUSP00000101485; ENSMUSG00000043924.
DR GeneID; 230822; -.
DR KEGG; mmu:230822; -.
DR UCSC; uc008vgh.2; mouse.
DR CTD; 400746; -.
DR MGI; MGI:2444888; Ncmap.
DR VEuPathDB; HostDB:ENSMUSG00000043924; -.
DR eggNOG; ENOG502S4WJ; Eukaryota.
DR GeneTree; ENSGT00390000004116; -.
DR InParanoid; Q99JS0; -.
DR OMA; PVDVHME; -.
DR TreeFam; TF336902; -.
DR BioGRID-ORCS; 230822; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Ncmap; mouse.
DR PRO; PR:Q99JS0; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q99JS0; protein.
DR Bgee; ENSMUSG00000043924; Expressed in sciatic nerve and 143 other tissues.
DR ExpressionAtlas; Q99JS0; baseline and differential.
DR Genevisible; Q99JS0; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
DR GO; GO:0033270; C:paranode region of axon; ISS:UniProtKB.
DR GO; GO:0043220; C:Schmidt-Lanterman incisure; ISS:UniProtKB.
DR GO; GO:0019911; F:structural constituent of myelin sheath; ISS:UniProtKB.
DR GO; GO:0032290; P:peripheral nervous system myelin formation; ISS:UniProtKB.
DR GO; GO:0031643; P:positive regulation of myelination; ISS:UniProtKB.
DR InterPro; IPR038940; NCMAP.
DR PANTHER; PTHR35974; PTHR35974; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..100
FT /note="Noncompact myelin-associated protein"
FT /id="PRO_0000265079"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..100
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 58..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 100 AA; 10846 MW; 6A30789C5C0368D0 CRC64;
MTTATTLGDA VFSLNMTRGE DALYKSSGAI VAAIVVVVII IVTLVLILLK MYNRRMRTRR
ELEPKSPKPP VPPALDPSSN GSQQPATVTF DPANVHVETR
