NCMAP_RAT
ID NCMAP_RAT Reviewed; 100 AA.
AC F1M2Z5;
DT 03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 38.
DE RecName: Full=Noncompact myelin-associated protein;
DE AltName: Full=Myelin protein of 11 kDa;
DE Short=MP11;
GN Name=Ncmap;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG Amgen EST program;
RT "Amgen rat EST program.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=18650334; DOI=10.1523/jneurosci.1659-08.2008;
RA Ryu E.J., Yang M., Gustin J.A., Chang L.W., Freimuth R.R., Nagarajan R.,
RA Milbrandt J.;
RT "Analysis of peripheral nerve expression profiles identifies a novel myelin
RT glycoprotein, MP11.";
RL J. Neurosci. 28:7563-7573(2008).
CC -!- FUNCTION: Plays a role in myelin formation.
CC {ECO:0000269|PubMed:18650334}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Note=Localized mainly in the Schmidt-
CC Lanterman incisures and paranodes of noncompact peripheral nerve
CC myelin. {ECO:0000269|PubMed:18650334}.
CC -!- TISSUE SPECIFICITY: Expressed in the peripheral nervous system Schwann
CC cells (at protein level). {ECO:0000269|PubMed:18650334}.
CC -!- INDUCTION: Up-regulated in Schwann cells by EGR2 during nerve
CC development and after nerve injury. {ECO:0000269|PubMed:18650334}.
CC -!- PTM: Glycosylated. {ECO:0000250}.
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DR EMBL; CB725228; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AABR06040402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR06040403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001240847.1; NM_001253918.1.
DR AlphaFoldDB; F1M2Z5; -.
DR SMR; F1M2Z5; -.
DR STRING; 10116.ENSRNOP00000064011; -.
DR PaxDb; F1M2Z5; -.
DR Ensembl; ENSRNOT00000073506; ENSRNOP00000064011; ENSRNOG00000048139.
DR GeneID; 689826; -.
DR KEGG; rno:689826; -.
DR CTD; 400746; -.
DR RGD; 1587554; Ncmap.
DR eggNOG; ENOG502S4WJ; Eukaryota.
DR InParanoid; F1M2Z5; -.
DR PRO; PR:F1M2Z5; -.
DR Proteomes; UP000002494; Chromosome 5.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0033270; C:paranode region of axon; IDA:UniProtKB.
DR GO; GO:0043220; C:Schmidt-Lanterman incisure; IDA:UniProtKB.
DR GO; GO:0019911; F:structural constituent of myelin sheath; IDA:UniProtKB.
DR GO; GO:0032290; P:peripheral nervous system myelin formation; IDA:UniProtKB.
DR GO; GO:0031643; P:positive regulation of myelination; IDA:UniProtKB.
DR InterPro; IPR038940; NCMAP.
DR PANTHER; PTHR35974; PTHR35974; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..100
FT /note="Noncompact myelin-associated protein"
FT /id="PRO_0000419538"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..100
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 58..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 100 AA; 10772 MW; 6E3C2DC6CA8C67C8 CRC64;
MTTATTLGDA VFSLNMTRGE DILYKSSGAI VAAIVVVVVI IVTLVLILLK MYNRRMRTRR
ELEPKSPKPP VPPALDPNSN GSQQPAAVTS DPADVPVETR
