ID   NCOA5_SCHMD             Reviewed;         545 AA.
AC   U6A492;
DT   10-FEB-2021, integrated into UniProtKB/Swiss-Prot.
DT   22-JAN-2014, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Nuclear receptor coactivator 5 {ECO:0000303|PubMed:24268775};
GN   Name=NCOA5 {ECO:0000303|PubMed:24268775};
OS   Schmidtea mediterranea (Freshwater planarian flatworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes;
OC   Rhabditophora; Seriata; Tricladida; Continenticola; Geoplanoidea;
OC   Dugesiidae; Schmidtea.
OX   NCBI_TaxID=79327 {ECO:0000312|EMBL:AHA14850.1};
RN   [1] {ECO:0000312|EMBL:AHA14850.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DISRUPTION
RP   PHENOTYPE, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=24268775; DOI=10.1016/j.celrep.2013.10.035;
RA   Boeser A., Drexler H.C., Reuter H., Schmitz H., Wu G., Schoeler H.R.,
RA   Gentile L., Bartscherer K.;
RT   "SILAC proteomics of planarians identifies Ncoa5 as a conserved component
RT   of pluripotent stem cells.";
RL   Cell Rep. 5:1142-1155(2013).
CC   -!- FUNCTION: Probable nuclear receptor coregulator that can have both
CC       coactivator and corepressor functions (By similarity). Important for
CC       maintenance of the adult pluripotent stem cell population
CC       (PubMed:24268775). {ECO:0000250|UniProtKB:Q9HCD5,
CC       ECO:0000269|PubMed:24268775}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9HCD5}.
CC   -!- TISSUE SPECIFICITY: Expressed in somatic stem cells. Also detected in
CC       testes where it appears to be expressed mainly in spermatocytes and
CC       round spermatids. {ECO:0000269|PubMed:24268775}.
CC   -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in severe
CC       impairment of regenerative capacity. The cycling stem cell population
CC       is significantly reduced at 8 days post-injection. Isolated stem cells
CC       are unable to repopulate an irradiated (and thus stem cell-depleted)
CC       host. {ECO:0000269|PubMed:24268775}.
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DR   EMBL; KF668097; AHA14850.1; -; mRNA.
DR   AlphaFoldDB; U6A492; -.
DR   SMR; U6A492; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0031099; P:regeneration; IMP:UniProtKB.
DR   GO; GO:0019827; P:stem cell population maintenance; IMP:UniProtKB.
DR   Gene3D; 3.30.70.330; -; 1.
DR   Gene3D; 3.40.50.800; -; 1.
DR   InterPro; IPR036621; Anticodon-bd_dom_sf.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Nucleus; RNA-binding; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..545
FT                   /note="Nuclear receptor coactivator 5"
FT                   /id="PRO_0000451999"
FT   DOMAIN          1..51
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          26..131
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          498..545
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..41
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..131
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        528..545
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   545 AA;  62241 MW;  9A26B674DF3B54EA CRC64;
     MNKHGKVIDV MISDRQALIQ FEREGDARRA VDREKGQSFR GNRIDVRFAS TSDGSFESRS
     EIPRNRSPRP LPYERDSRDM SPYRDSGRDR SPADRERYYK ALRRGDSSKI IEEPENLNNR
     HGSPDSYRKY DRSRGIVEEP RSRSQLHQDY PVIPKEIQEP KWNSPPFTDK IGTERPGFDA
     AIIVMSSELL SYAETIESRL QRQIALTTHI IVLKEESHAN ACVEDLNNKG VLYAFLVNSL
     NEQHFSCTLR ILYGTPQEHR NMPLNNALTF VARNFERYQK HVRDLKTIAP KPTFDPSRMP
     PGFIAPDDKI IYYLHLLADS RMLTIEELNE VIDFVQKRMQ ALASAEETME KAPITGLPNE
     SVQNSMAPKL SIPGNQPVRE EKVIQHQTQL HSKILNILKP VPHQSASGVV DNEINNMEQF
     NTYNDSNIST SKSNNMVINP KVQQALDTLM QSQFRPTAPE LSAPAEENSR NFQPVNNPMA
     NPYSMNPTPN MRPINPHSTQ QRPMAQGPGG QPFGNSFHGY YQPPIGQPIF RGRPPFQPRP
     QYPGY