NCOR1_XENTR
ID NCOR1_XENTR Reviewed; 2494 AA.
AC Q4KKX4;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Nuclear receptor corepressor 1;
DE Short=N-CoR;
DE Short=N-CoR1;
DE Short=xN-CoR;
GN Name=ncor1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates transcriptional repression by certain nuclear
CC receptors. Participates in complexes which promote histone
CC deacetylation and the formation of repressive chromatin structures
CC which may impede access by the basal transcription machinery (By
CC similarity). In association with hdac3, may play a role in the
CC regulation of the circadian clock (By similarity).
CC {ECO:0000250|UniProtKB:Q60974, ECO:0000250|UniProtKB:Q8QG78}.
CC -!- SUBUNIT: Forms a large corepressor complex that contains sin3a/b,
CC histone deacetylases hdac1 and hdac2, rbbp4 and possibly rbbp7.
CC Interacts with the thyroid receptor (TR, composed of rxra and thrb) and
CC the retinoid acid receptor (RAR, composed of rxra and rara) in the
CC absence of ligand. Interacts with tbl1xr1. Interacts with zbtb33/kaiso
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624}.
CC -!- DOMAIN: The CORNR box motifs in the C-terminal region may be necessary
CC and sufficient for binding to unligated nuclear hormone receptors.
CC Sequences flanking these motifs may determine the precise nuclear
CC hormone receptor specificity (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000305}.
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DR EMBL; BC099620; AAH99620.1; -; mRNA.
DR RefSeq; NP_001027513.1; NM_001032342.1.
DR AlphaFoldDB; Q4KKX4; -.
DR SMR; Q4KKX4; -.
DR STRING; 8364.ENSXETP00000014702; -.
DR PaxDb; Q4KKX4; -.
DR PRIDE; Q4KKX4; -.
DR GeneID; 613105; -.
DR KEGG; xtr:613105; -.
DR CTD; 9611; -.
DR Xenbase; XB-GENE-483288; ncor1.
DR eggNOG; KOG1878; Eukaryota.
DR InParanoid; Q4KKX4; -.
DR OrthoDB; 12227at2759; -.
DR Reactome; R-XTR-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity.
DR Reactome; R-XTR-383280; Nuclear Receptor transcription pathway.
DR Reactome; R-XTR-400206; Regulation of lipid metabolism by PPARalpha.
DR Reactome; R-XTR-9029569; NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux.
DR Reactome; R-XTR-9623433; NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis.
DR Proteomes; UP000008143; Chromosome 2.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046966; F:nuclear thyroid hormone receptor binding; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51293; SANT; 2.
PE 2: Evidence at transcript level;
KW Biological rhythms; Chromatin regulator; Coiled coil; DNA-binding; Nucleus;
KW Reference proteome; Repeat; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..2494
FT /note="Nuclear receptor corepressor 1"
FT /id="PRO_0000055621"
FT DOMAIN 427..478
FT /note="SANT 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT DOMAIN 622..668
FT /note="SANT 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 134..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..304
FT /note="Interaction with tbl1xr1"
FT /evidence="ECO:0000250"
FT REGION 198..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 981..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1081..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1413..1434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1488..1585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1745..1845
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1912..1987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2018..2105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2135..2216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2346..2413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2446..2494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 168..208
FT /evidence="ECO:0000255"
FT COILED 502..549
FT /evidence="ECO:0000255"
FT COILED 698..726
FT /evidence="ECO:0000255"
FT COILED 1771..1810
FT /evidence="ECO:0000255"
FT MOTIF 2008..2012
FT /note="CORNR box 1"
FT MOTIF 2119..2123
FT /note="CORNR box 2"
FT MOTIF 2322..2326
FT /note="CORNR box 3"
FT COMPBIAS 145..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..562
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..692
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..725
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..814
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..863
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 877..893
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1006
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1100..1124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1413..1427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1488..1503
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1504..1556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1565..1585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1771..1811
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1914..1932
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1933..1973
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2085..2105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2135..2181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2186..2203
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2348..2377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2385..2413
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2446..2472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2494 AA; 277212 MW; 7E862943961012FA CRC64;
MSSSGYPPNQ GAFSTEQGRY SSHPVQYTFP SSRHQQEFPV PEYRSSHLEA SQLLQQQQLR
RRPSLLSEFH PVSDRPQDRR QGYEQQYHSV TQNEHEALES KRPRLDVSDS HYRVGAASVV
PLVPTIQEGV RVQSEVKKEQ GLPSKHETTS SPLSGQPGEE QEASPSKLSK EELIQSMDRV
DREIAKVEQQ ILKLKKKQQQ LEEEAAKPPE PEKPVSPPPV EQKHRSIVQI IYDENRKKAE
EAHKILEGLG PKVELPLYNQ PSDTKVYHEN IKTNQVMRKK LILFFKRRNH ARKLREQNIC
QRYDQLMEAW EKKVDRIENN PRRKAKESKT REYYEKQFPE IRKQREQQER FQRVGQRGAG
LSATIARSEH EISEIIDGLS EQENNEKQMR QLSVIPPMMF DAEQRRVKFI NMNGLMEDPM
KVYKDRQFMN VWTDHEKEIF KEKFVQHPKN FGLIASYLER KTVSDCVLYY YLTKKNENFK
ALVRRNYPKR RGRNQQQITR PAQEEKEIEK VEEEKAERND KKEEERREEE EKEEKEELRD
GTKDRTDAIA EDGEDKEQST PRGRKTANSQ GRRKGRITRS MASEAAAAAN AASTATTAPA
TTTSTTATTT TAALVPVAPP PEEPTPPPTQ EQSLVEHGRN WGAIAKMVGS KSESQCKNFY
FNYKRRHNLD NLLQQHKQKS SRRPREERDV SQCESVASTV SAQEDEENEA SNEEENAEDS
EGAENSSDTE SAPSPSPAEA AKLGDDAVDR TTSSVSIEAP PEQDAASKSV SDSSPTPTVE
NIKPPETQYT ELKVKEEIST ETEEAMEVEE RSQGAEIKST LSLPVQTKAE PDEVESKPSE
SAEVKIEEDT KDQDMERLMD RAEATDMVYA PPLHISRGRQ ESQSDNDSSA TCSADEEVDG
EPERPRIYTL DSKPSLLNPA GTILISSSMK QGPMDLQQLQ HRAAVIPPMA SCSPCNITTG
TSNFSMYQRH LYENNLLEEQ RQRQEQLSLE SRMSASPGNM SKSPNMDWEG KSVYMPYTEV
KRAFEHEAQM QNVARSVSPY RLSPREVSRA SPQVDMNPAR YCVPPVLQPA PHQVITSLSD
GARLPVTRPT RPPPPLIPSS KTSATSSDKP SFITGGSISQ GTPGTYLTSL SQSYSQETVK
PSVGSISLGL PRQQESAKTG SVTYIKQEEF SPRGQSSQPE GLLVRAQHEG VVRGTMTAIQ
EGSITRGTPA TKVPIEAVST LRGSITQGTP ALSQSGIAAD VLLKTTITRL ATEDIGSPER
CRDETSAKGH VIYEGKSGHI VSYDTAIKNM REGTRSPRTA PEVTLKRTFD TMEGNIKQAM
SVREAAVSGP MEGLICRTLP KGSTHAEIKD RQVLSGSIMK GTPRTTSDSF EDGLKYAKQI
KLESPPIRSF EGAISKGKPY ECVTTIKEMG RSIHEIPRQD LGSQESRKTP ESSRQIIEGS
ISQGTPIKYE GTSGQSAIKH NVKSLITGPS NLSRGLPQME VMPENLKMGE RSKYEDTKSS
EAIRSRHTSV VSSGPSVLRS TLHEASKSQL SPGVYEDNNA RRTPVNYPSP MSRSSPMARS
AEVGLTPGKS SSHERKSTLT PTQRENIVVK SPVPGVDPTA AHSPFDPHLR GAPPGDVYRT
HLPPHLDPAL QFHRPLDPAA AAAYLFQRQL SPTPGYPSQY QLYAMENTRQ TILNDYITSQ
QMQVNLRPDV ARGLSPRDQG LAIPYPGARG IIDLTNMPPA ILVPHPGGTS TPPMDRITYI
PGTQLAFPPR PYNPASMSPG HPTHLAAANS VSAERERERE RDRERDRERE KEQRERERDR
ERERERLAAA PSDHYLRPVS EQPGRPGSHG FVRSPSPSVR AQESIMQQRP SIFQGTNGKS
VITPLDAAQL RIMPPTPGAA SITQGIPASR YSTAADALAA LVDAAASAPQ MEVVKPKEMK
HDPARSEESL SRRNVLEQQQ QQQQIDCERR VMQSPYTSSS FSGSKSQGQP SPAVYSEAGK
EKTAHTKSRY VEELRMRGKT TITAANFIDV IITQQIASDK DGRDRNSQSS DSSSSHSSHR
YDAPRDTIEV ISPANSPVQE KESYPPEIPK SSQTESESSR KYEGQPNRYR QQQESPSPQQ
TIPGHVPQTH RLITLADHIC QIITQDFARN QPVNQALQQP PASTFQSTNP SSTPVRTKAS
SRFSPESQVQ PVHNQRPASR VSPENVLDRP RGRPGKSPDR GHISEPYEPI SPPQAPLLHA
KQDSMLLLSQ RQEPPEQRND SRSPGNISYL PSFFTKLENT SPMVMYKKQE IFRKLNSSGG
GDSEMAAAQP GTEIFNLPAV TTSGAISSRG HSFADPASNL GLEDIIRKAL MGNFDDKSED
HSVLVGVAQG NPSGTQNSEA RREEANPSPN SGGGTHKQKL ISKYGSRKTK SPISGSQTYL
GAERPSSVSS VHSEGDYRQA SAWAWEDRPS STGSTQFPYN PLTMGMLNST PPSSMSCAPT
SMTQTSAHQQ SRIWEREPAP LLSEQYETLS DSDE
