ID   NCTR1_BOVIN             Reviewed;         308 AA.
AC   Q863H2;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Natural cytotoxicity triggering receptor 1;
DE   AltName: Full=Natural killer cell p46-related protein;
DE            Short=NK-p46;
DE            Short=NKp46;
DE   AltName: CD_antigen=CD335;
DE   Flags: Precursor;
GN   Name=NCR1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Spleen;
RX   PubMed=12672064; DOI=10.1002/eji.200323710;
RA   Storset A.K., Slettedal I.O., Williams J.L., Law A., Dissen E.;
RT   "Natural killer cell receptors in cattle: a bovine killer cell
RT   immunoglobulin-like receptor multigene family contains members with
RT   divergent signaling motifs.";
RL   Eur. J. Immunol. 33:980-990(2003).
CC   -!- FUNCTION: Cytotoxicity activating receptor that may contribute to the
CC       increased efficiency of activated natural killer (NK) cells to mediate
CC       tumor cell lysis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CD3Z and FCER1G. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Selectively expressed by NK cells.
CC       {ECO:0000269|PubMed:12672064}.
CC   -!- SIMILARITY: Belongs to the natural cytotoxicity receptor (NCR) family.
CC       {ECO:0000305}.
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DR   EMBL; AF422181; AAP33623.1; -; mRNA.
DR   RefSeq; NP_899209.1; NM_183365.1.
DR   AlphaFoldDB; Q863H2; -.
DR   SMR; Q863H2; -.
DR   STRING; 9913.ENSBTAP00000053976; -.
DR   PaxDb; Q863H2; -.
DR   Ensembl; ENSBTAT00000064403; ENSBTAP00000053976; ENSBTAG00000045529.
DR   GeneID; 369024; -.
DR   KEGG; bta:369024; -.
DR   CTD; 9437; -.
DR   VEuPathDB; HostDB:ENSBTAG00000045529; -.
DR   VGNC; VGNC:31926; NCR1.
DR   eggNOG; ENOG502RWVC; Eukaryota.
DR   GeneTree; ENSGT01000000214458; -.
DR   HOGENOM; CLU_021100_1_1_1; -.
DR   InParanoid; Q863H2; -.
DR   OMA; TGMYDIP; -.
DR   OrthoDB; 1327293at2759; -.
DR   TreeFam; TF336644; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000045529; Expressed in neutrophil and 42 other tissues.
DR   ExpressionAtlas; Q863H2; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   Pfam; PF13895; Ig_2; 1.
DR   SMART; SM00409; IG; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..308
FT                   /note="Natural cytotoxicity triggering receptor 1"
FT                   /id="PRO_0000015026"
FT   TOPO_DOM        22..259
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        281..308
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          34..118
FT                   /note="Ig-like 1"
FT   DOMAIN          124..207
FT                   /note="Ig-like 2"
FT   CARBOHYD        139
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        49..98
FT                   /evidence="ECO:0000250|UniProtKB:O76036"
FT   DISULFID        144..190
FT                   /evidence="ECO:0000250|UniProtKB:O76036"
SQ   SEQUENCE   308 AA;  34494 MW;  B4F5A0E0CC4F0702 CRC64;
     MPSTLAVFLV LGLGLSQRSS TQKQMLSKPA IWVRPSFMIP KGRSATIGCR GAGEAMEYQL
     HFEGGLSALK RPKSSPVMNW VKFPIPAMTS HTAGQYRCSY RSGELWSELS DPLELVVTGL
     YDTPTLSVEP RSEVTSGENV TFHCQLATAT STFFLLKKGR SSRPQLRYGN LRAEFHLGPV
     TPAHGGTYRC FGSYNNHAWS FPSKPVKLLV KVPGDAGDTT FAPTEHTSSD YWDSYELTTG
     TQSQKDHLLW NHMIQNLIRL GLAVLVLVAL MGFLLEDWLH RRKSQERAHR ASRRGCRRRL
     RAQRALET