ID   NCTR1_MACFA             Reviewed;         306 AA.
AC   Q95JB9;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Natural cytotoxicity triggering receptor 1;
DE   AltName: Full=Natural killer cell p46-related protein;
DE            Short=NK-p46;
DE            Short=NKp46;
DE   AltName: CD_antigen=CD335;
DE   Flags: Precursor;
GN   Name=NCR1;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Lymphoid tissue;
RX   PubMed=11745374;
RX   DOI=10.1002/1521-4141(200112)31:12<3546::aid-immu3546>3.0.co;2-w;
RA   De Maria A., Biassoni R., Fogli M., Rizzi M., Cantoni C., Costa P.,
RA   Conte R., Mavilio D., Ensoli B., Cafaro A., Moretta A., Moretta L.;
RT   "Identification, molecular cloning and functional characterization of NKp46
RT   and NKp30 natural cytotoxicity receptors in Macaca fascicularis NK cells.";
RL   Eur. J. Immunol. 31:3546-3556(2001).
CC   -!- FUNCTION: Cytotoxicity-activating receptor that may contribute to the
CC       increased efficiency of activated natural killer (NK) cells to mediate
CC       tumor cell lysis. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CD3Z and FCER1G. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in NK cells.
CC       {ECO:0000269|PubMed:11745374}.
CC   -!- SIMILARITY: Belongs to the natural cytotoxicity receptor (NCR) family.
CC       {ECO:0000305}.
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DR   EMBL; AJ278288; CAC41080.1; -; mRNA.
DR   RefSeq; NP_001271509.1; NM_001284580.1.
DR   AlphaFoldDB; Q95JB9; -.
DR   SMR; Q95JB9; -.
DR   STRING; 9541.XP_005590406.1; -.
DR   ABCD; Q95JB9; 1 sequenced antibody.
DR   GeneID; 102115479; -.
DR   CTD; 9437; -.
DR   eggNOG; ENOG502RWVC; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   SMART; SM00409; IG; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..306
FT                   /note="Natural cytotoxicity triggering receptor 1"
FT                   /id="PRO_0000015028"
FT   TOPO_DOM        22..257
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        279..306
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          42..100
FT                   /note="Ig-like 1"
FT   DOMAIN          137..192
FT                   /note="Ig-like 2"
FT   CARBOHYD        216
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        49..98
FT                   /evidence="ECO:0000250|UniProtKB:O76036"
FT   DISULFID        144..190
FT                   /evidence="ECO:0000250|UniProtKB:O76036"
SQ   SEQUENCE   306 AA;  34652 MW;  EC6B84DEBB46538B CRC64;
     MSSTLRALLC LGLCLSQRIS APKQTLPKPI IRAESTYMVP KEKQATLCCQ GSYGAVEYQL
     HFEGSLFAVE RPKPPERING VKFHIPDMNS RKAGRYSCIY RVGELWSERS DLLDLVVTEM
     YDTPTLSVHP GPEVTSGEKV TFYCRLDTAT SMFLLLKEGR SRDVQRSYGK VQAEFPMGPV
     TTAHRGSYRC FGSYNNYAWS FPSEPVKLLV TGDIENTSLA PTDPTFPDSW DTCLLTRETG
     LQKDLALWDH TAQNLLRMGL AFLVLVALVC LLVEDWLSRK RTREQASRAS TWEGRRRLNK
     HKDSEE